Persistence of K103N-Containing HIV-1 Variants after Single-Dose Nevirapine for Prevention of HIV-1 Mother-to-Child Transmission

Flys, Tamara S.; Donnell, Deborah; Mwatha, Anthony; Nakabiito, Clemensia; Musoke, Philippa; Mmiro, Francis; Jackson, J. Brooks; Guay, Laura A.; Eshleman, Susan H.
March 2007
Journal of Infectious Diseases;3/1/2007, Vol. 195 Issue 5, p711
Academic Journal
K103N-containing human immunodeficiency virus (HIV)-1 variants are selected in some women who receive single-dose (SD) nevirapine (NVP) for prevention of HIV-1 mother-infant transmission. We examined the persistence of K103N in women who received SD NVP prophylaxis. K103N was detected using the LigAmp assay (assay cutoff, 0.5% K103N). K103N was detected at 6-8 weeks in 60 (41.7%) of 144 women. Fading (lack of detection) of K103N was documented in 16 women by 2 years, 43 women by 3 year, and 55 women by 4 and 5 years. Slower fading was independently associated with HIV-1 subtype (D>A) and higher pre-NVP viral load.


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