Experimental Design Approaches in Method Optimization

vander Heyden, Yvan
September 2006
LC-GC Europe;Sep2006, Vol. 19 Issue 9, p469
Trade Publication
Proper ‘data handling’ means that the data to be treated should be acquired in a suitable way. The use of experimental designs makes it possible to define a priori the experiments to be executed and the data to be collected. Data handling of the results obtained should lead to method conditions satisfying the need(s) of the separation considered. This article describes the experimental design-based approaches applied in the development and optimization of separation methods.


Related Articles

  • Experimental Study of Informal Rewards in Peer Production. Restivo, Michael; van de Rijt, Arnout // PLoS ONE;Mar2012, Vol. 7 Issue 3, p1 

    We test the effects of informal rewards in online peer production. Using a randomized, experimental design, we assigned editing awards or "barnstars" to a subset of the 1% most productive Wikipedia contributors. Comparison with the control group shows that receiving a barnstar increases...

  • Designing Intelligent Instruments. Knuth, Kevin H.; Erner, Philip M.; Frasso, Scott // AIP Conference Proceedings;11/13/2007, Vol. 954 Issue 1, p203 

    Remote science operations require automated systems that can both act and react with minimal human intervention. One such vision is that of an intelligent instrument that collects data in an automated fashion, and based on what it learns, decides which new measurements to take. This innovation...

  • Rugby-like hohlraum experimental designs for demonstrating x-ray drive enhancement. Amendt, Peter; Cerjan, C.; Hinkel, D. E.; Milovich, J. L.; Park, H.-S.; Robey, H. F. // Physics of Plasmas;Jan2008, Vol. 15 Issue 1, p012702 

    A suite of experimental designs for the Omega laser facility [Boehly et al., Opt. Commun. 133, 495 (1997)] using rugby and cylindrical hohlraums is proposed to confirm the energetics benefits of rugby-shaped hohlraums over cylinders under optimal implosion symmetry conditions. Postprocessed...

  • A new experimental design for noncontact giant magnetoresistance measurements using the magnetorefractive effect. Vopsaroiu, M.; Matthew, J. A. D.; Thompson, S. M. // Review of Scientific Instruments;Oct2004 Part I & II, Vol. 75 Issue 10, p3127 

    Electrical magnetoresistance measurements of spin dependent materials or devices are very difficult without surface damaging or sample contamination, especially for thin-film giant magnetoresistance (GMR) multilayers. Moreover, the in situ determination of the GMR profile is almost impossible...

  • Use of response surface methodology for development of new microwell-based spectrophotometric method for determination of atrovastatin calcium in tablets. Wani, Tanveer A; Ahmad, Ajaz; Zargar, Seema; Khalil, Nasr; Darwish, Ibrahim A // Chemistry Central Journal;2012, Vol. 6 Issue 1, p134 

    Background: Response surface methodology by Box-Behnken design employing the multivariate approach enables substantial improvement in the method development using fewer experiments, without wastage of large volumes of organic solvents, which leads to high analysis cost. This methodology has not...

  • COMPARISON BETWEEN EFFICIENCY OF RECTANGULAR SEDIMENTATION TANKS USING SINGLE AND SERIES WEIRS IN THEIR INLET ZONE. Mehmanravesh, Samira; Khezri, Seyed Mustafa; Gharehbagh, Vahid Mohammadzadeh // International Journal of Academic Research;Nov2011, Vol. 3 Issue 6, p355 

    Sedimentation tanks are one of the main and costly units of a treatment plant which is responsible to separation of part of suspended particles in water. An optimal design for these tanks improves their performance remarkably. Therefore, any factor influencing their performance worth being...

  • Using a hybrid approach to optimize experimental network design for aquifer parameter identification. Liang-Cheng Chang; Hone-Jay Chu; Yu-Pin Lin; Yu-Wen Chen // Environmental Monitoring & Assessment;Oct2010, Vol. 169 Issue 1-4, p133 

    This research develops an optimum design model of groundwater network using genetic algorithm (GA) and modified Newton approach, based on the experimental design conception. The goal of experiment design is to minimize parameter uncertainty, represented by the covariance matrix determinant of...

  • Best Bang for Your Buck-Part 1. ANDERSON-COOK, CHRISTINE M.; LU LU // Quality Progress;Oct2016, Vol. 49 Issue 10, p45 

    The article reports on learning through designed experiments as a sequential process. Topics discussed include design of experiments, strategically planning for the use of resources at different stages of data collection, and maximizing the knowledge gained. Also being discussed are...

  • Bridging the Gap between Researcher and Practitioner. Wood, Donald M. // International Studies of Management & Organization;Fall88, Vol. 18 Issue 3, p88 

    This article seeks to develop some suggestions for international academics and managers on the basis of a brief examination of management research representing three research designs in current use: survey research, field experiments, and the multiple method approach. A brief discussion of the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics