TITLE

Limitations of Estimating Glomerular Filtration Rate From Serum Creatinine in the General Population

AUTHOR(S)
Rule, Andrew D .; Rodeheffer, Richard J.; Larson, Timothy S.; Burnett, Jr., John C .; Cosio, Fernando G .; Turner, Stephen T .; Jacobsen, Steven J.
PUB. DATE
November 2006
SOURCE
Mayo Clinic Proceedings;Nov2006, Vol. 81 Issue 11, p1427
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE: To compare estimated glomerular filtration rate (GFR) In the general population on the basis of equations derived from different subsets of the general population. PARTICIPANTS AND METHODS: Adults (ages =45 years) were randomly selected from 1997 to 2000 from the Olmsted County, Minnesota, population and had their serum creatinine levels measured. The GFR was estimated using previously reported equations derived from a sample of patients with chronic kidney disease (CKD), a sample of healthy persons, and the combined samples. Serum creatinine was measured with the same assay used to derive these equations. RESULTS: Of 4203 subjects, 2042 (47% participation rate) were enrolled and studied. Serum samples from 1982 subjects were used to measure creatinine levels. The prevalence of a reduced estimated GFR (<60 mL/min per 1.73 m�) was 12% (95% confidence interval [CI], 10%-13%) based on an equation derived with all CKD patients, and this finding was similar to prior reports. However, the prevalence of a reduced estimated GFR was 5.7% (95% CI, 4.8V6.8%) based on an equation derived with both CKD patients and healthy persons and 0.2% (95% CI, 0.1%-0.5%) based on an equation derived with all healthy persons. Women had a higher risk of reduced estimated GFR according to an equation derived with all CKD patients, but men had a higher risk with an equation derived with both CKD patients and healthy persons. CONCLUSION: The use of serum creatinine to diagnose CKD requires a different approach (eg, normal value study) from the use of serum creatinine to estimate GFR once the diagnosis of CKD has been made.
ACCESSION #
23863953

 

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