Review: Rofecoxib increases renal events and arrhythmia, but a COX-2-inhibitor class effect does not exist

Molony, Donald A.
January 2007
ACP Journal Club;Jan/Feb2007, Vol. 146 Issue 1, p25
Academic Journal
The article discusses a research study regarding the risk factors for renal and arrhythmia events in patients using cyclooxygenase-2 (COX-2) inhibitors. The study was conducted by researcher J. Zhang, and published in the "Journal of the American Medical Association." Use of rofecoxib increases risks for renal events and arrhythmia. Evidence of increased risk associated with other COX-2 inhibitors is not supported, indicating no overall class effect.


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