Positron Emission Tomography in Relation to Noguchi’s Classification for Diagnosis of Peripheral Non-Small-Cell Lung Cancer 2 cm or Less in Size

Tsunezuka, Y.; Shimizu, Y.; Tanaka, N.; Takayanagi, T.; Kawano, M.
February 2007
World Journal of Surgery;Feb2007, Vol. 31 Issue 2, p314
Academic Journal
F-18 fluorodeoxyglucose positron emission tomography (18F-FDG-PET) scanning has become a critically important tool in diagnosis and management of non-small-cell lung cancer. However, the effectiveness of 18F-FDG-PET as a diagnostic tool for small-sized lung cancer is controversial. The purpose of this study was to examine the accuracy of 18F-FDG-PET in relation to Noguchi’s classification in the diagnosis of small peripheral non-small-cell lung cancer. Between January 2003 and April 2006, 150 patients with peripheral lung lesions who were undergoing chest computed tomography (CT), 18F-FDG-PET, and operation were analyzed. Eighty-three patients had malignant lesions, and 67 patients had benign lesions. PET had a sensitivity, specificity, positive predictive value, and negative predictive value of 75.9%, 64.1%, 72.4%, and 68.3%, respectively. In 37 patients with peripheral lung cancer measuring 2.0 cm or less in the greatest diameter, the sensitivity was 51.4% and the specificity was 51.9%. Among them, all 4 cases of Noguchi type A adenocarcinoma [localized bronchioloalveolar carcinoma (LBAC)], 4 of 5 type B and 8 of 17 type C were false negative, while 9 of 11 (81.8%) types D, E, and F (invasive carcinomas without a BAC component) were true positive. The accuracy of 18F-FDG-PET is generally low in distinguishing malignancy from benign lesions in small lesions (<2.0-cm diameter). The significance of PET as a diagnostic tool is small, especially when the tumor has a ground-glass component at a high rate. The sensitivity of PET is high in small invasive carcinomas without a BAC component, but it is difficult to distinguish carcinoma from benign tumor from its image.


Related Articles

  • A Positron-Emitting Internal Marker for Identification of Normal Tissue by Positron Emission Tomography: Phantom Studies and Validation in Patients. Thomas, Cherry T.; Meyer, Charles R.; Koeppe, Robert A.; Kalemkerian, Gregory P.; Fisher, Susan J.; Dull, Terry L.; Zasadny, Kenneth R.; Wahl, Richard L. // Molecular Imaging & Biology;Mar2003, Vol. 5 Issue 2, p79 

    PURPOSE: This study evaluated in a phantom model and verified in patients with lung cancer whether the use of an internal positron-emitting labeled marker could localize a critical structure by positron emission tomography (PET) imaging and verify multimodality image registration.MATERIALS AND...

  • Integrated 18F-Fluorodeoxyglucose-Positron Emission Tomography/Dynamic Contrast-Enhanced Computed Tomography to Phenotype Non-Small Cell Lung Carcinoma. Shastry, Manu; Miles, Kenneth A.; Win, Thida; Janes, Sam M.; Endozo, Raymond; Meagher, Marie; Ell, Peter J.; Groves, Ashley M. // Molecular Imaging;Sep/Oct2012, Vol. 11 Issue 5, p353 

    We applied modern molecular and functional imaging to the pretreatment assessment of lung cancer using combined dynamic contrast-enhanced computed tomography (DCE-CT) and 18F-fluorodeoxyglucose-positron emission tomography (18F-FDG-PET) to phenotype tumors. Seventy-four lung cancer patients were...

  • CyberKnife radiosurgery for inoperable stage IA non-small cell lung cancer: 18F-fluorodeoxyglucose positron emission tomography/computed tomography serial tumor response assessment. Vahdat, Saloomeh; Oermann, Eric K.; Collins, Sean P.; Xia Yu; Abedalthagafi, Malak; DeBrito, Pedro; Suy, Simeng; Yousefi, Shadi; Gutierrez, Constanza J.; Chang, Thomas; Banovac, Filip; Anderson, Eric D.; Esposito, Giuseppe; Collins, Brian T. // Journal of Hematology & Oncology;2010, Vol. 3, p1 

    Objective: To report serial 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) tumor response following CyberKnife radiosurgery for stage IA non-small cell lung cancer (NSCLC). Methods: Patients with biopsy-proven inoperable stage IA NSCLC were enrolled...

  • Miscellaneous.  // Current Medical Literature: Lung Cancer;2012, Vol. 6 Issue 1, p24 

    The article discusses several studies related to lung cancer. One study focused on the cost effectiveness of positron emission tomography in staging of non-small-cell lung cancer (NSCLC) and management of solitary pulmonary nodules. Another study assessed knowledge of lung cancer symptoms and...

  • Integrating PET and CT for Lung Cancer Staging. Zepf, Bill // American Family Physician;2/15/2004, Vol. 69 Issue 4, p953 

    Discusses research being done on the comparative diagnostic accuracy of separate and combined computed tomography (CT) and positron-emission tomography (PET) imaging for the staging of non-small-cell lung cancer. Reference to a study by D. Lardinois et al published in the June 19, 2003 issue of...

  • Low dose non-enhanced CT versus standard dose contrast-enhanced CT in combined PET/CT protocols for staging and therapy planning in non-small cell lung cancer. Pfannenberg, Anna C.; Aschoff, Philip; Brechtel, Klaus; Müller, Mark; Bares, Roland; Paulsen, Frank; Scheiderbauer, Jutta; Friedel, Godehard; Claussen, Claus D.; Eschmann, Susanne M. // European Journal of Nuclear Medicine & Molecular Imaging;Jan2007, Vol. 34 Issue 1, p36 

    To evaluate low dose non-enhanced CT and standard dose contrast-enhanced CT in combined PET/CT protocols for staging and therapy planning of non-small cell lung cancer (NSCLC). Retrospective analysis was performed of 50 consecutive patients with proven NSCLC who had been referred for primary...

  • Imaging techniques for tumour delineation and heterogeneity quantification of lung cancer: overview of current possibilities. van Elmpt, Wouter; Zegers, Catharina M. L.; Das, Marco; De Ruysscher, Dirk // Journal of Thoracic Disease;Apr2014, Vol. 6 Issue 4, p319 

    No abstract available.

  • A review on the clinical uses of SPECT/CT. Mariani, Giuliano; Bruselli, Laura; Kuwert, Torsten; Kim, Edmund E.; Flotats, Albert; Israel, Ora; Dondi, Maurizio; Watanabe, Naoyuki // European Journal of Nuclear Medicine & Molecular Imaging;Oct2010, Vol. 37 Issue 10, p1959 

    In the era when positron emission tomography (PET) seems to constitute the most advanced application of nuclear medicine imaging, still the conventional procedure of single photon emission computed tomography (SPECT) is far from being obsolete, especially if combined with computed tomography...

  • PET/CT-guided radiation therapy planning: From present to the future. Beriwal, Gupta T. // Indian Journal of Cancer;Apr-Jun2010, Vol. 47 Issue 2, p126 

    Molecular imaging using 18F–fluoro–deoxyglucose positron emission tomography⁄computed tomography (FDG–PET/CT) has been successfully used in the diagnosis, initial staging, and response assessment of various malignant tumors. Advances in radiation therapy planning and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics