Can Dynamic Susceptibility Contrast Magnetic Resonance Imaging Replace Single‐Photon Emission Computed Tomography in the Diagnosis of Patients with Alzheimer's Disease? A Pilot Study

Cavallin, L.; Danielsson, R.; Öksengard, A. R.; Wahlund, L. O.; Julin, P.; Frank, A.; Engman, E. L.; Svensson, L.; Wiberg, Kristoffersen M.
November 2006
Acta Radiologica;Nov2006, Vol. 47 Issue 9, p977
Academic Journal
Purpose: To compare single‐photon emission computed tomography (SPECT) and magnetic resonance imaging (MRI) in a cohort of patients examined for suspected dementia, including patients with no objective cognitive impairment (control group), mild cognitive impairment (MCI), and Alzheimer's disease (AD).Material and Methods: Twenty‐four patients, eight with AD, 10 with MCI, and six controls were investigated with SPECT using 99mTc‐hexamethylpropyleneamine oxime (HMPAO) and dynamic susceptibility contrast magnetic resonance imaging (DSC‐MRI) with gadobutrol. Three observers performed a visual interpretation of the SPECT and MR images using a four‐point visual scale.Results: SPECT was superior to DSC‐MRI in differentiating normal from pathological. All three observers showed statistically significant results in discriminating between the control group, AD, and MCI by SPECT, with a P value of 0.0006, 0.04, and 0.01 for each observer. The statistical results were not significant for MR (P values 0.8, 0.1, and 0.2, respectively).Conclusion: DSC‐MRI could not replace SPECT in the diagnosis of patients with Alzheimer's disease. Several patient‐ and method‐related improvements should be made before this method can be recommended for clinical practice.


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