- Peripherally Delivered Glutamic Acid Decarboxylase (GAD) Gene Therapy for Below-Level Spinal Cord Injury Neuropathic Pain // Molecular Therapy;May2004 Supplement 1, Vol. 9, p82
An abstract of the article "Peripherally Delivered Glutamic Acid Decarboxylase (GAD) Gene Therapy for Below- Level Spinal Cord Injury Neuropathic Pain," by Darren Wolfe, Liu Jun, Hao Shuanglin, Huang Shuahua, Marina Mata, Joseph Glorioso and David Fink is presented.
- Limbic encephalitis with antibodies to glutamic acid decarboxylase presenting with brainstem symptoms. Incecik, Faruk; Hergüner, Ozlem M.; Yıldızdaş, Dincer; Horoz, Ozden; Besen, Seyda // Annals of Indian Academy of Neurology;Apr2015, Vol. 18 Issue 2, p243
Limbic encephalitis (LE) is a neurological syndrome that may present in association with cancer, infection, or as an isolate clinical condition often accompanying autoimmune disorders. LE associated with glutamic acid decarboxylase antibodies (anti-GAD) is rare in children. Here, we...
- Clinical, Autoimmune, and Genetic Characteristics of Adult-Onset Diabetic Patients With GAD Autoantibodies in Japan (Ehime Study). Takeda, Haruyo; Yamawaki, Takashi; Onuma, Hiroshi; Osawa, Haruhiko; Makino, Hideichi; Nishimiya, Tatsuya; Kawasaki, Eiji; Shimizu, Ikki; Fujii, Yasuhisa; Kato, Kenichi; Konoue, Etsushi; Kondo, Shiori; Fujiyama, Masao; Murao, Satoshi; Tanaka, Kiyonobu; Takada, Yasuharu; Mori, Kennichi; Kitsuki, Nobuaki; Tarumi, Yopshinao; Kaino, Yukikazu // Diabetes Care;Jun2002, Vol. 25 Issue 6, p995
Focuses on a study that characterized the clinical, autoimmune and genetic features in Japanese adult-onset diabetic patients with glutamic acid decarboxylase autoantibodies. Research design and methods; Results; Conclusions.
- Back on her feet. Barakat, Christine // Equus;Dec2012, Issue 423, p15
The article discusses the Stiff Horse Syndrome, an autoimmune dysfunction that produces glutamic acid decarboxylase slowing down the nerve cells activity. Lutz Goehring, DVM, PhD, states the condition while chronic can be treated with corticosteroids and attentive care. An overview of the story...
- Cortical dysfunction in cerebellar ataxia with antibodies to glutamic acid decarboxylase. Simon, Neil; Vucic, Steve; Joffe, Ronald; Kiernan, Matthew // Journal of Neurology;Jan2014, Vol. 261 Issue 1, p238
A letter to the editor about the case of a 52-year-old female patient with cortical dysfunction which was a feature of cerebellar ataxia associated with glutamic acid decarboxylase (GAD) antibodies.
- syrinx. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p727
An encyclopedia entry for "syrinx" is presented. It refers to an abnormal cavity in the brainstem or spinal cord.
- Electroacupuncture counteracts the development of thermal hyperalgesia and the alteration of nerve growth factor and sensory neuromodulators induced by streptozotocin in adult rats. Manni, L.; Florenzano, F.; Aloe, L. // Diabetologia;Jul2011, Vol. 54 Issue 7, p1900
ims/hypothesis: Diabetes is considered the leading cause of neuropathies in developed countries. Dysfunction of nerve growth factor (NGF) production and/or utilisation may lead to the establishment of diabetic neuropathies. Electroacupuncture has been proved effective in the treatment of human...
- Unaltered cytochrome oxidase, glutamate dehydrogenase and glutaminase activities in platelets from patients with Sporadic Amyotrophic Lateral Sclerosis : A study of potential pathogenetic mechanisms in neurodegenerative diseases. Gluck, M. R.; Thomas, R. G.; Sivak, M. A. // Journal of Neural Transmission;Dec2000, Vol. 107 Issue 12, p1437
Summary. Sporadic Amyotrophic Lateral Sclerosis (SALS) is a fatal neurologic disease characterized by degeneration of motor neurons in the spinal cord, brainstem and cortex. While familial cases of ALS exist, the sporadic form accounts for the majority of adult-onset cases. It has been...
- Immunization against GAD Induces Antibody Binding to GAD-Independent Antigens and Brainstem GABAergic Neuronal Loss. Chang, Thashi; Alexopoulos, Harry; Pettingill, Philippa; McMenamin, Mary; Deacon, Robert; Erdelyi, Ferenc; Szabó, Gabor; Buckley, Camilla J.; Vincent, Angela // PLoS ONE;Sep2013, Vol. 8 Issue 9, p1
Stiff person syndrome (SPS) is a highly-disabling neurological disorder of the CNS characterized by progressive muscular rigidity and spasms. In approximately 60â€“80% of patients there are autoantibodies to glutamic acid decarboxylase (GAD), the enzyme that synthesizes gamma-amino butyric...
- Antiâ€“Glutamic Acid Decarboxylase Antibody Associated Limbic Encephalitis in a Child: Expanding the Spectrum of Pediatric Inflammatory Brain Diseases. Mishra, Navin; Rodan, Lance H.; Nita, Dragos A.; Gresa-Arribas, Nuria; Kobayashi, Jeff; Benseler, Susanne M. // Journal of Child Neurology;May2014, Vol. 29 Issue 5, p677
Antiâ€“glutamic acid decarboxylase directed antibodies are a rare cause of autoimmune limbic encephalitis that is relatively resistant to immunotherapy. Here we report a 15-year-old boy with nonparaneoplastic, antiâ€“glutamic acid decarboxylase limbic encephalitis presenting with...