TITLE

Evaluation of a diphtheria—tetanus—acellular pertussis—inactivated poliovirus—Haemophilus influenzae lype b vaccine given concurrently with meningococcal group C conjugate vaccine at 2, 3 and 4 months of age

AUTHOR(S)
Kitchin, N. R. E.; Southern, J.; Morris, R.; Hemme, F.; Thomas, S.; Watson, M. W.; Cartwright, K.; Miller, E.
PUB. DATE
January 2007
SOURCE
Archives of Disease in Childhood;Jan2007, Vol. 92 Issue 1, p11
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and objective: In view of the possible introduction of diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophi!us influenzae type b (DTaP-IPV-Hib, eg Pediacel) vaccine in the UK, a study of the immunogenicity of Pediacel when given with one of two different meningococcal group C conjugate (MCC) vaccines at 2, 3 and 4 months of age was conducted. Methods: Randomised controlled study in 241 infants. Results: Post vaccination, the proportion of infants with anti-polyribosylribitol phosphate (PRP) levels ⩾0.15 µ/ml was 93.2% (95% confidence interval (CI) 86.6 to 96.7) in the Pediacel group compared with 100% (95% CI 96.4 to 100) in the diphtheria-tetanus-whole-cell pertussis-Haemophi!us inlluenzae type b (DTwP-Hib) group. The anti-PRP response was lower in infants receiving either Pediacel or DTwP-Hib when these vaccines were given concomitantly with meningococcal group C conjugate with diphtheria-derived protein CRM197 as conjugate protein (MCC-CRM) compared with meningococcal group C conjugate with tetanus toxoid as conjugate protein (MCC-TT). For group C meningococcus, the proportion of infants with serum bactericidal antibody (SBA) litre ⩾1:8 in the Pediacel group was 99.0% compared with 100% in the DTwP-Hib group. The MCC SBA geometric mean titre (GMT) was lower in those receiving Pediacel with MCC-TT than in those receiving DTwP-Hib with MCC-TT, although all titres were well above the protective threshold. The MCC SBA GMT was similar in those receiving Pediacel and DTwP-Hib and MCC-CRM. Responses to all other vaccine components were equivalent in the two groups. Conclusions: Pediacel is immunogenic when given at 2, 3 and 4 months of age. Coadministration of MCC vaccine can influence the Hib response, and the MCC response to a tetanus conjugate can be influenced by the nature of the coadministered DTP-Hib vaccine.
ACCESSION #
23779046

 

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