Evaluation of a diphtheria—tetanus—acellular pertussis—inactivated poliovirus—Haemophilus influenzae lype b vaccine given concurrently with meningococcal group C conjugate vaccine at 2, 3 and 4 months of age

Kitchin, N. R. E.; Southern, J.; Morris, R.; Hemme, F.; Thomas, S.; Watson, M. W.; Cartwright, K.; Miller, E.
January 2007
Archives of Disease in Childhood;Jan2007, Vol. 92 Issue 1, p11
Academic Journal
Background and objective: In view of the possible introduction of diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophi!us influenzae type b (DTaP-IPV-Hib, eg Pediacel) vaccine in the UK, a study of the immunogenicity of Pediacel when given with one of two different meningococcal group C conjugate (MCC) vaccines at 2, 3 and 4 months of age was conducted. Methods: Randomised controlled study in 241 infants. Results: Post vaccination, the proportion of infants with anti-polyribosylribitol phosphate (PRP) levels ⩾0.15 µ/ml was 93.2% (95% confidence interval (CI) 86.6 to 96.7) in the Pediacel group compared with 100% (95% CI 96.4 to 100) in the diphtheria-tetanus-whole-cell pertussis-Haemophi!us inlluenzae type b (DTwP-Hib) group. The anti-PRP response was lower in infants receiving either Pediacel or DTwP-Hib when these vaccines were given concomitantly with meningococcal group C conjugate with diphtheria-derived protein CRM197 as conjugate protein (MCC-CRM) compared with meningococcal group C conjugate with tetanus toxoid as conjugate protein (MCC-TT). For group C meningococcus, the proportion of infants with serum bactericidal antibody (SBA) litre ⩾1:8 in the Pediacel group was 99.0% compared with 100% in the DTwP-Hib group. The MCC SBA geometric mean titre (GMT) was lower in those receiving Pediacel with MCC-TT than in those receiving DTwP-Hib with MCC-TT, although all titres were well above the protective threshold. The MCC SBA GMT was similar in those receiving Pediacel and DTwP-Hib and MCC-CRM. Responses to all other vaccine components were equivalent in the two groups. Conclusions: Pediacel is immunogenic when given at 2, 3 and 4 months of age. Coadministration of MCC vaccine can influence the Hib response, and the MCC response to a tetanus conjugate can be influenced by the nature of the coadministered DTP-Hib vaccine.


Related Articles

  • Just the jab.  // New Scientist;9/23/95, Vol. 147 Issue 1996, p8 

    Informs the likely success of the ongoing tests under guidance of Public Health Laboratory Service in Britain for a combination vaccine for diphtheria, tetanus, whooping cough and Hib (Haemophilus influenzae type b).

  • Immunogenicity and reactogenicity of a novel hexavalent DTPa-HBV-IPV/Hib vaccine compared to separate concomitant injections of DTPa-IPV/Hib and HBV vaccines, when administered according to a 3, 5 and 11 month vaccination schedule. Avdicová, Mária; Prikazský, Viktor; Hudecková, Henrieta; Schuerman, Lode; Willems, Paul // European Journal of Pediatrics;2002, Vol. 161 Issue 11, p581 

    In an open randomised trial, 312 eligible infants were enrolled to receive either a single injection of the hexavalent diphtheria-tetanus-acellular pertussishepatitis B virus-inactivated polio/Haemophilus influenzae b (DTPa-HBV-IPV/Hib) vaccine, or concomitant injections of commercial...

  • DTaP5-IPV-Hib Vaccine (Pediacel®). Frampton, James E. // Pediatric Drugs;2011, Vol. 13 Issue 6, p401 

    Pediacel® is a fully liquid formulation of a diphtheria, tetanus, five-component acellular pertussis, inactivated poliovirus and Haemophilus influenzae type b combination vaccine, which does not require reconstitution. Both vial and prefilled syringe presentations of Pediacel® are...

  • DTPa-HBV-IPV/Hib Vaccine (Infanrix hexaâ„¢): A Viewpoint by Scott A. Halperin. Halperin, Scott A. // Drugs;2003, Vol. 63 Issue 7, p683 

    Reports on a combination vaccine for children that offers protection against diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b. Details regarding immunogenicity and reactogenicity of the vaccine; Advantages of introducing combination vaccines for children; Reaction caused by...

  • What a difference a vaccine makes. MacDermott, Siobhan // World of Irish Nursing & Midwifery;Jul/Aug2006, Vol. 14 Issue 7, p47 

    The article focuses on the significance of vaccination in preventing diseases. The author points out that vaccination has been very successful in controlling diseases in Ireland but people should not be complacent. He outlines some immunization programs aimed on measles, pertussis and...

  • New combination vaccines still need a boost. Pollard, A. J. // Archives of Disease in Childhood;Jan2007, Vol. 92 Issue 1, p1 

    The author comments on the paper "Evaluation of a Diphtheria-Tetanus-Acellular Pertussis-Inactivated Poliovirus-Haemophilus Influenza Type B Vaccine Given Concurrently with Meningococcal Group C Conjugate Vaccine at 2,3 and 4 months of Age" that was published within the issue. According to the...

  • Vaccine Interchangeability. Greenberg, David P.; Feldman, Sandor // Clinical Pediatrics;Mar2003, Vol. 42 Issue 2, p93 

    Presents the safety and immunogenicity data for immunization regime that use vaccines from diferent manufacturers. Acellular pertussis vaccine; Hepatitis B virus vaccine; Poliovirus vaccine; Haemophilus influenzae type B vaccine.

  • The Induction of Immunologic Memory after Vaccination with Haemophilus influenzae Type b Conjugate and Acellular Pertussis-Containing Diphtheria, Tetanus, and Pertussis Vaccine Combination. Goldblatt, D.; Richmond, P.; Millard, E.; Thornton, C.; Miller, E. // Journal of Infectious Diseases;8/1/99, Vol. 180 Issue 2 

    Examines the induction of immunologic memory after vaccination with Hemophilus influenzae type b (Hib) conjugate and acellular pertussis. Reduction of anti-Hib polysaccharide; Administration of polyribitolribosyl phosphate and Hib conjugate vaccines; Comparison between whole cell pertussis and...

  • Concentration and Avidity of Anti--Haemophilus influenzae Type b (Hib) Antibodies in Serum Samples Obtained from Patients for Whom Hib Vaccination Failed. Breukels, Mijke A.; Jol-van der Zijde, Els M.; van Tol, Maarten J. D.; Rijkers, Ger T. // Clinical Infectious Diseases;1/15/2002, Vol. 34 Issue 2, p191 

    Haemophilus influenzae type b (Hib) conjugate vaccines are extremely effective in protecting infants and children from invasive Hib infections; however, vaccine failures do occur. The anti-Hib antibody production was studied both quantitatively and qualitatively in 12 patients who experienced...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics