Cerebral atrophy and skull thickening due to chronic phenytoin therapy

Chow, Kai Ming; Szeto, Cheuk Chun
January 2007
CMAJ: Canadian Medical Association Journal;1/30/2007, Vol. 176 Issue 3, p321
Academic Journal
The article evaluates the chronic phenytoin therapy in a patient with a history of refractory epilepsy and mental insufficiency with encephalitis. Clinical implications of skull thickening and cerebral atrophy are offered. The result of the CT scan after a head injury is presented. Effects of phenytoin on skull thickening are discussed.


Related Articles

  • Phenytoin.  // Reactions Weekly;2/24/2007, Issue 1140, p18 

    This article presents the case of a woman who developed cerebellar atrophy and generalized skull thickening. A computed tomography scan revealed her condition. Her antiepileptic drug therapy had included phenytoin, valproic acid, pregabalin and clobazam. The scan had been prompted by a head...

  • Why do some patients after head injury deteriorate over the long term? Fleminger, Simon // Journal of Neurology, Neurosurgery & Psychiatry;Nov2012, Vol. 83 Issue 11, p1036 

    The author discusses the complications of the head injury like subdural haematoma. He also discusses the explanations for the complications including accelerated cerebral atrophy, chronic inflammation and depleted cerebral reserve. A study conducted by Wang and colleagues regarding the...

  • Traumatic dural sinus thrombosis causing persistent headache in a child. Lakhkar, Bhavana; Lakhkar, Bhushan; Singh, Brij Raj; Agrawal, Amit // Journal of Emergencies, Trauma & Shock;Jan2010, Vol. 3 Issue 1, p73 

    Dural venous sinus thrombosis following a mild head injury is increasingly recognized. We report case of a 9-year-old male child presented with progressive headache and vomiting following a minor fall. A diagnosis of sinus venous thrombosis was suspected on nonenhancing computed tomography, and...

  • Unverricht-Lundborg Disease in Turkey: Delineating The Phenotype Between Cystatin B Mutation Positive and Negative Cases. Erdınç, Oğuz Osman; Joensuu, Tarja; İlğen-Uslu, Ferda; Bebek, Nerses; Özkara, Çiğdem; Tutkavul, Kemal; Gündüz, Ayşegül; Lehesjoki, Anna-Elina; Baykan, Betül // Journal of Neurological Sciences;2010, Vol. 27 Issue 1, p1 

    Objective: We herein report the first three genetically proven Unverricht-Lundborg disease (ULD) patients in Turkey and their clinical comparisons with eight CSTB mutation negative patients who were suspected to have ULD. Materials and Methods: Eleven progressive myoclonic epilepsy (PME)...

  • AKT answer relating to head injury.  // InnovAiT;Oct2011, Vol. 4 Issue 10, p603 

    A quiz concerning the use of computerized tomography (CT) for head injuries is presented.

  • Who needs a CT brain scan? Ashworth, Bryan // British Medical Journal (Clinical Research Edition);3/29/1986, Vol. 292 Issue 6524, p845 

    Focuses on the clinical assessment for computed tomography (CT). Conditions requiring CT scan; Significance of CT scan in patients with head injury; Diagnostic value of scans in patients with psychiatric disorders.

  • Which emergency department patients with minor head injuries require computed tomography? Jin, Eddie; Bullard, Michael J. // CJEM: Canadian Journal of Emergency Medicine;May2002, Vol. 4 Issue 3, p209 

    Examines whether highly sensitive and clinically sensible decision rule can be developed to guide the use of computed tomography scanning in adults with minor head injuries. Blunt trauma to the head resulting in definite amnesia; Reliability of radiographic interpretations; Need for...

  • Admission after mild head injury: benefits and costs. Mendelow, A.D.; Campbell, D.A.; Jeffrey, R.R.; Miller, J.D.; Hessett, C.; Bryden, J.; Jennett, B. // British Medical Journal (Clinical Research Edition);11/27/1982, Vol. 285 Issue 6354, p1530 

    Examines costs and benefits of admission after mild head injury in hospitals in Great Britain. Increase in the incidence of head injury in the country; Policy on the admission of patients with history of unconsciousness of hematoma; Reliability of computed tomography in detecting intracranial...

  • Necessity of CT scanning in cases of mild head trauma. Sadovsky, Richard // American Family Physician;11/1/1995, Vol. 52 Issue 6, p1879 

    Reports on an article published by Borczuk in the June 1995 issue of `Annals of Emergency Medicine' on the necessity of computed tomography (CT) scanning in cases of mild head trauma.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics