TITLE

Prenatal predictors of mortality in very preterm infants cared for in the Australian and New Zealand Neonatal Network

AUTHOR(S)
Evans, N.; Hutchinson, J.; Simpson, J. M.; Donoghue, D.; Darlow, B.; Henderson-Smart, D.
PUB. DATE
January 2007
SOURCE
Archives of Disease in Childhood -- Fetal & Neonatal Edition;Jan2007, Vol. 92 Issue 1, pF34
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Aim: To identify antenatal and perinatal risk factors for in-hospital mortality of babies born within the Australian and New Zealand Neonatal Network (ANZNN). Methods: Data were collected prospectively as part of the ongoing audit of high-risk infants (birth weight <1500 g or gestation <32 weeks) admitted to all level III neonatal units in Australia and New Zealand. Antenatal and intrapartum factors to 1 mm of age were examined in 11 498 infants with gestational age >24 weeks. Risk and protective factors for mortality were derived from logistic regression models fitted to 1998-9 data and validated on 2000-1 data. Results: For the whole cohort of infants born between 1 998 and 2001, prematurity was the dominant risk factor, infants born at 25 weeks having 32 times greater odds of death than infants born at 31 weeks. Low birth weight for gestational age also had a dose-response effect: the more growth restricted the infant the greater the risk of mortality; infants below the 3rd centile had eight times greater odds of death than those between the 25th and 75th centiles. Male sex was also a significant risk factor (odds ratio (OR) 1 .55, 95% confidence interval (CI) 1.31 to 1.82). Maternal hypertension in pregnancy was protective (OR 0.46, 95% CI 0.36 to 0.50). The predictive model for mortality had an area under the receiver operating characteristic curve of 0.82. Conclusions: Risk of mortality can be predicted with good accuracy with factors up to the 1 mm Apgar score. By using gestation rather than birth weight as the main indicator of maturity, these data confirm that weight for gestational age is an independent risk factor for mortality.
ACCESSION #
23753775

 

Related Articles

  • Update from EPICure.  // Infant;Jan2013, Vol. 9 Issue 1, p21 

    The article informs that two reports from the EPICure study published in the British Medical Journal have revealed that while the number of preterm babies who survive may continue to rise, the number of children and adults with longterm disability caused by premature birth may rise in parallel.

  • Why Aren't We Up In Arms About Babies Dying?  // Glamour;Jun2012, Vol. 110 Issue 6, p156 

    The article reports on the murder and mortality rates of infants in 2010 and ways to prevent prematurity and infant mortality.

  • Outcomes following the surgical ligation of the patent ductus arteriosus in premature infants in Scotland. Heuchan, Anne Marie; Hunter, Lindsey; Young, David // Archives of Disease in Childhood -- Fetal & Neonatal Edition;Jan2012, Vol. 97 Issue 1, pF39 

    Objective To determine morbidity, mortality and associated risk factors following patent ductus arteriosus (PDA) ligation in premature infants. Methods Retrospective case note audit of premature infants referred to a national paediatric cardiothoracic surgical service (2001-2007) with univariate...

  • Are Black and Hispanic Infants with Specific Congenital Heart Defects at Increased Risk of Preterm Birth? Nembhard, Wendy N.; Salemi, Jason L.; Loscalzo, Melissa L.; Tao Wang; Hauser, Kimberlea W. // Pediatric Cardiology;Aug2009, Vol. 30 Issue 6, p800 

    Congenital heart defects (CHDs) are a leading cause of infant morbidity and mortality. Infants with CHDs have increased risk of preterm birth (PTB) compared to infants without birth defects. Although non-Hispanic (NH) Blacks are more likely to be born preterm and Hispanics have rates similar to...

  • Panel Reviews Health Effects Data for Assisted Reproductive Technologies. Hampton, Tracy // JAMA: Journal of the American Medical Association;12/22/2004, Vol. 292 Issue 24, p2961 

    Presents the findings of a panel put together to study the health of children conceived through in vitro fertilization (IVF). 25 years after the first baby conceived through IVF and nearing the birth of the 2 millionth baby, the long-term health consequences which have yet to be determined;...

  • Early prediction of complex midgut volvulus in neonates and infants. Kanellos-Becker, Ilias; Bergholz, Robert; Reinshagen, Konrad; Boettcher, Michael // Pediatric Surgery International;Jun2014, Vol. 30 Issue 6, p579 

    Introduction: Prognosis of midgut volvulus in neonates and infants younger than 1 year remains poor, as diagnostic findings may not be apparent until gut infarction had occurred. To characterize factors that help to predict complex midgut volvulus early was aim of this study. Methods:...

  • Infant mortality: Delivery date may count more than birth weight.  // Nation's Health;Apr95, Vol. 25 Issue 4, p13 

    Presents a study which suggest that researchers should focus on preventing preterm birth rather than increasing birth weights in order to improve United States poor ranking in infant morality. Details of the study; Comments by Dr. Allen Wilcox and Dr. Melissa M. Adams; Nation Institute of...

  • Fifteen million and rising--number of premature births every year. Gulland, Anne // BMJ: British Medical Journal (Overseas & Retired Doctors Edition;5/5/2012, Vol. 344 Issue 7855, p6 

    The article reports the findings of a report by a coalition that includes the World Health Organization (WHO) and the charity Save the Children, that the proportion of preterm babies was rising in nearly every country, and that 15 million babies are born before 37 weeks gestation every year.

  • Survival predictors of preterm neonates: Hospital based study in Iran (2010-2011). Haghighi, Ladan; Nojomi, Marzieh; Mohabbatian, Behnaz; Najmi, Zahra // Iranian Journal of Reproductive Medicine;Dec2013, Vol. 11 Issue 12, p957 

    Background: Preterm birth (PTB) is responsible for 70% of neonatal mortalities. Various factors influence the risk of neonatal mortality in different populations. Objective: Our objective was to evaluate neonatal survival rate of preterm infants, and to define its predictors in Iranian...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics