TITLE

Twelve-Month Tolerability and Safety of Sumatriptan--Naproxen Sodium for the Treatment of Acute Migraine

AUTHOR(S)
Winner, Paul; Cady, Roger K.; Ruoff, Gary E.; Frishberg, Benjamin M.; W. James Alexander; Ying Zhang; Kori, Shashidhar H.; Lener, Shelly E.
PUB. DATE
January 2007
SOURCE
Mayo Clinic Proceedings;Jan2007, Vol. 82 Issue 1, p61
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVES: To evaluate the long-term safety and tolerability of sumatriptan-naproxen sodium for the treatment of moderate to severe acute migraines and to assess the safety of administration of an optional second dose. PATIENTS AND METHODS: A 12-month, multicenter, open-label safety study was conducted In adults treated for migraine attacks of moderate to severe Intensity from April 14, 2004, to August 18, 2005. Safety evaluations Included adverse events and laboratory tests. RESULTS: Of 600 patients enrolled, 565 (94%) were treated for at least 1 migraine. Of treated patients, 414 (73%) and 362 (64%) completed 6 and 12 months of treatment, respectively. Of the. 24,485 attacks treated, 17,144 (70%) were treated with only 1 dose. On average, patients treated 5 migraine attacks per month, with a median of 6 days between attacks. The most common treatment-related adverse events were nausea, muscle tightness, and dizziness. Fourteen patients reported I or more serious adverse event with only 1 judged probably related to treatment. No deaths occurred. Eight percent of patients discontinued participation In the study because of adverse events or pregnancy. The rates of adverse events reported were no higher after treatment with 2 tablets (at least 2 hours apart) compared with 1 tablet. CONCLUSIONS: In this 12-month data set of more than 24,000 migraine attacks in 565 patIents, sumatriptan-naproxen sodium formulated In a single tablet was well tolerated when used episodically for the treatment of acute migraine. The adverse events did not differ from those expected for the Individual components alone, and no new or unexpected findings occurred.
ACCESSION #
23737586

 

Related Articles

  • sumatriptan. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p721 

    An encyclopedia entry for "sumatriptan" is presented. It is a serotonin agonist drug used to relieve acute attacks of migraine and effective in treating cluster headaches. The drug is also used by people who have migraines that do not respond to analgesic drugs. Side effects of the drugs include...

  • Repeat triptan use uncommon for migraine in Israel.  // PharmacoEconomics & Outcomes News;10/21/2006, Issue 514, p7 

    The article reveals that many patients with migraine choose not to use triptans after their first experience with the drugs, according to research conducted in Israel. Reasons for the single use of triptans include recurrence of headache, side effects, and lack of superiority over other headache...

  • Preventing medication overuse headache: The nurse's role in educating patients. Gillies, Catherine // British Journal of Neuroscience Nursing;Jun2009, Vol. 5 Issue 6, p278 

    Medication overuse headache is one of the most common complications of primary headaches, i.e. migraines. Analgesia such as paracetamol which is available over the counter, and others prescribed by general practitioners, can cause this secondary headache. This condition makes diagnosis and...

  • almotriptan.  // Davis's Drug Guide for Nurses, 10th edition;2007, p106 

    The article presents a nursing guide for the vascular headache suppressant almotriptan. The drug is used for the acute treatment of migraine headache. It explains the pharmacokinetics, contraindications, precautions, adverse reactions and side effects of the drug. Its nursing implications are...

  • Patient Preferences for Migraine Therapy: Subcutaneous Sumatriptan Compared with Other Medications. Luciani, Ralph J.; Osterhaus, Jane T.; Gutterman, Donna L. // Journal of Family Practice;Aug1995, Vol. 41 Issue 2, p147 

    Background. This study was conducted to identify, from the patient's perspective, the important attributes of a migraine therapy and to assess the performance of subcutaneous sumatriptan, aspirin, acetaminophen, and patients' usual therapies with respect to these attributes. Methods. Six hundred...

  • headaches. Gressor, Megan // Good Medicine (Australian Consolidated Press);Feb2004, Special Section p1 

    Provides information on headaches. Physical causes of tension headaches, such as poor posture; Discussion on headaches in children; Symptoms of migraines; Treatment for headaches, such as analgesics and sumatriptan.

  • How to Prevent or Reverse Medication Overuse Headache. Williams, Glenn S. // Neurology Reviews;Sep2015, Vol. 23 Issue 9, p8 

    The article discusses the prevention or reversal of medication overuse headache (MOH). Topics covered include Doctor Stewart J. Tepper's elaboration of MOH recognition and diagnosis during the 57th Annual Meeting of the American Headache Society, the predictors of escalating frequency of...

  • TRIPTANS.  // Complete Guide to Prescription & Nonprescription Drugs 2012;2012, p820 

    The article presents information on triptans, an antimigraine drug, including its dosage, usage, adverse reactions, side effects, precautions when administering, and possible interaction with other drugs.

  • methysergide. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p505 

    An encyclopedia entry for "methysergide" is presented. It is a drug used to prevent migraine and cluster headaches, and is usually administered only under hospital supervision when other treatments have been ineffective. Several adverse effects of the drug are noted, including dizziness,...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics