Inflammatory bowel disease: is it really just another break in the wall?

Weber, C. R.; Turner, J. R.
January 2007
Gut;Jan2007, Vol. 56 Issue 1, p6
Academic Journal
Although the critical factors necessary for IBD pathogenesis remain mysterious, interest in the potential role of defective epithelial barrier function continues to grow. New insight into the mechanisms responsible for barrier dysfunction in IBD may lead to understanding its contribution to disease development and progression.


Related Articles

  • Expression of p53, VEGF, microvessel density, and cyclin-D1 in noncancerous tissue of inflammatory bowel disease. Alkim, Canan; Savas, Berna; Ensari, Arzu; Alkim, Huseyin; Dagli, Ulku; Parlak, Erkan; Ulker, Aysel; Sahin, Burhan // Digestive Diseases & Sciences;Sep2009, Vol. 54 Issue 9, p1979 

    We aimed to evaluate the carcinogenesis risk in inflammatory bowel disease via p53 mutation and its relation with hyperproliferation (cyclin-D1) and angiogenesis (with vascular endothelial growth factor [VEGF] and microvessel density) and whether these events play important roles in pathogenesis...

  • Disorders of a modern lifestyle: reconciling the epidemiology of inflammatory bowel diseases. Bernstein, Charles N.; Shanahan, Fergus // Gut;Sep2008, Vol. 57 Issue 9, p1185 

    The article offers a perspective on some of the more consistent epidemiological observations in inflammatory bowel diseases (IBD). It attempts to reconcile them with current concepts of disease mechanisms. The article discusses the environmental or lifestyle risk factors associated with IBD. It...

  • Cox-2 deletion in myeloid and endothelial cells, but not in epithelial cells, exacerbates murine colitis. Ishikawa, Tomo-o; Oshima, Masanobu; Herschman, Harvey R. // Carcinogenesis;Mar2011, Vol. 32 Issue 3, p417 

    Patients with inflammatory bowel diseases are at increased risk for colorectal cancer. Pharmacological inhibition of cyclooxygenase (COX) function exacerbates symptoms in colitis patients. Animal models of colitis using Cox-2-knockout mice and COX inhibitors also indicate that COX-2 has a...

  • A dirty cure for inflammatory bowel disease.  // Gastrointestinal Nursing;Sep2008, Vol. 6 Issue 7, p4 

    The article reports on the role of exposure to harmless microbes early in life in lowering the risk of inflammatory bowel disease (IBD). The hygiene hypothesis postulates that children raised in an ultra-clean environment are more likely to develop IBD. It is said that environment as a key...

  • Effectiveness of IκB kinase inhibitors in murine colitis-associated tumorigenesis. Hayakawa, Yoku; Maeda, Shin; Nakagawa, Hayato; Hikiba, Yohko; Shibata, Wataru; Sakamoto, Kei; Yanai, Ayako; Hirata, Yoshihiro; Ogura, Keiji; Muto, Susumu; Itai, Akiko; Omata, Masao // Journal of Gastroenterology;2009, Vol. 44 Issue 9, p935 

    Nuclear factor κB (NF-κB) activation is involved in various inflammatory illnesses, for example inflammatory bowel disease, and is thought to be a key factor in the tumor-promoting mechanism of inflammation-associated tumorigenesis. This study investigated whether inhibitors of IKKβ,...

  • Clinical value of serum eosinophilic cationic protein assessment in children with inflammatory bowel disease. Wędrychowicz, Andrzej; Tomasik, Przemysław; Pieczarkowski, Stanisław; Kowalska-Duplaga, Kinga; Grzenda-Adamek, Zofia; Fyderek, Krzysztof // Archives of Medical Science;Dec2014, Vol. 10 Issue 6, p1142 

    Introduction: Eosinophils contribute to the pathogenesis of inflammatory bowel disease (IBD) in the intestine. Eosinophilic cationic protein (ECP) is one of the most important eosinophilic specific mediators released during activation. The aim of the study was to evaluate the clinical value of...

  • Epidemiology of Inflammatory Bowel Diseases in Iran and Asia; A Mini Review. Safarpour, Ali Reza; Hosseini, Seyed Vahid; Mehrabani, Davood // Iranian Journal of Medical Sciences;Jun2013 Supplement, Vol. 38, p140 

    The prevalence of inflammatory bowel diseases (IBDs) is set to stabilize in Western Europe and North America, as opposed to its increasing trend in developing countries in Asia. The epidemiology of IBDs in areas where the incidence and prevalence are relatively low provides an opportunity for...

  • Characteristics of Japanese inflammatory bowel disease susceptibility loci. Arimura, Yoshiaki; Isshiki, Hiroyuki; Onodera, Kei; Nagaishi, Kanna; Yamashita, Kentaro; Sonoda, Tomoko; Matsumoto, Takayuki; Takahashi, Atsushi; Takazoe, Masakazu; Yamazaki, Keiko; Kubo, Michiaki; Fujimiya, Mineko; Imai, Kohzoh; Shinomura, Yasuhisa // Journal of Gastroenterology;Aug2014, Vol. 49 Issue 8, p1217 

    Background: There are substantial differences in inflammatory bowel disease (IBD) genetics depending on the populations examined. We aimed to identify Japanese population-specific or true culprit susceptibility genes through a meta-analysis of past genetic studies of Japanese IBD. Methods: For...

  • Association Between Immune-Associated Disorders and Adverse Outcomes of Ileal Pouch-Anal Anastomosis. Shen, Bo; Remzi, Feza H.; Nutter, Benjamin; Bennett, Ana E.; Lashner, Bret A.; Lavery, Ian C.; Brzezinski, Aaron; .Bambrick, Marlene L; Queener, Elaine; Fazio, Victor W. // American Journal of Gastroenterology;Mar2009, Vol. 104 Issue 3, p655 

    OBJECTIVES:Autoimmune disorders (ADs) frequently coexist with inflammatory bowel disease. The aim of the study was to determine whether coexisting AD in patients with ileal pouches increases the risk for chronic antibiotic-refractory pouchitis (CARP) and other inflammatory conditions of the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics