TITLE

Is Crohn's disease due to defective immunity?

AUTHOR(S)
Korzenik, J. R.
PUB. DATE
January 2007
SOURCE
Gut;Jan2007, Vol. 56 Issue 1, p2
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The understanding of the pathophysiology of Crohn's disease is currently undergoing a reassessment. The concept of this disease as a primary I cell disorder is being questioned, with a new emphasis on the role of innate immunity in initiating early events and in perpetuating the inflammatory state. Crohn's disease has been proposed instead to result from impaired innate immunity, encompassing the mucosal barrier and cellular elements including neutrophils and macrophages. Recent advances in genetics, functional studies on innate immunity and therapeutic trials on patients with Crohn's disease have lent support to this evolving hypothesis.
ACCESSION #
23627611

 

Related Articles

  • Micro-RNAs as regulators and possible diagnostic bio-markers in inflammatory bowel disease Archanioti, Paraskevi; Gazouli, Maria; Theodoropoulos, George; Vaiopoulou, Anna; Nikiteas, Nikolaos // Journal of Crohn's & Colitis;Dec2011, Vol. 5 Issue 6, p520 

    Abstract: Not fully defined pathophysiologic mechanisms of inflammatory bowel disease (IBD) involve an array of genetic, epigenetic, infectious, physiological and immunological factors. Nowadays, an inadequate activation of the innate immune system to a luminal factor occurring in genetically...

  • Unravelling the complex genetics of inflammatory bowel disease. Russell, R. K.; Wilson, D. C.; Satsangi, J. // Archives of Disease in Childhood;Jul2004, Vol. 89 Issue 7, p598 

    The rapid pace of progress in molecular genetics over the past 15 years-since the seminal description of the polymerase chain reaction-has led to the identification of the genes involved in many single gene disorders. These successes in the laboratory have already led directly to clinical...

  • Innate immunity includes defensins. Jägra, Simon; Wehkampb, Jan; Stangea, Eduard F. // Annals of Gastroenterology;Jan2012, Vol. 25, p3 

    The authors comment on a study by T. Karantanos et al on genetics and innate immunity in inflammatory bowel disease (IBD). They agree with the authors' appreciation of the important role of innate immune sensing and the production of antimicrobial peptides in maintaining the integrity of the...

  • Association of NOD2 with Crohn's Disease in a homogenous Irish population. Bairead, Emer; Harmon, Dawn L; Curtis, Anne M; Kelly, Yvette; O'Leary, Clare; Gardner, Michelle; Leahy, Dermot T; Vaughan, Pat; Keegan, Denise; O'Morain, Colm; O'Donoghue, Diarmuid; Shanahan, Fergus; Parfrey, Nollaig A; Quane, Kathleen A // European Journal of Human Genetics;Mar2003, Vol. 11 Issue 3, p237 

    Linkage of IBD to the pericentromeric region of chromosome 16 has been widely confirmed by analyses of multiple populations. The NOD2 gene is located in the peak region of linkage on chromosome 16 and thought to be involved in the activation of nuclear factor (NF) κB in response to bacterial...

  • Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's disease. Yamazaki, K.; Takazoe, M.; Tanaka, T.; Kazumori, T.; Nakamura, Y. // Journal of Human Genetics;2002, Vol. 47 Issue 9, p469 

    Chronic inflammatory bowel diseases (IBDs), specifically Crohn's disease (CD) and ulcerative colitis (UC), have increased significantly in western countries and Japan over the last decade, but very little is known about their pathogenesis. A candidate-gene approach recently identified...

  • Nucleotide-binding oligomerization domain containing 1 (NOD1) haplotypes and single nucleotide polymorphisms modify susceptibility to inflammatory bowel diseases in a New Zealand Caucasian population: a case-control study. Huebner, Claudia; Ferguson, Lynnette R.; Dug Yeo Han; Philpott, Martin; Barclay, Murray L.; Gearry, Richard B.; McCulloch, Alan; Demmers, Pieter S.; Browning, Brian L. // BMC Research Notes;2009, Vol. 2, p1 

    Background: The nucleotide-binding oligomerization domain containing 1 (NOD1) gene encodes a pattern recognition receptor that senses pathogens, leading to downstream responses characteristic of innate immunity. We investigated the role of NOD1 single nucleotide polymorphisms (SNPs) on IBD risk...

  • Kronik enflamatuar barsak hastalıkları. Çullu Çokuğraş, Fügen // Turkish Pediatrics Archive / Turk Pediatri Arsivi;mar2011 supplement, Vol. 46, p70 

    There are two main types of chronic inflamatory bowel diseases: crohn's disease affecting the whole gastrointestinal system from oral cavity to rectum and ulcerative colitis affecting only the colon. A third group of such diseases consist of indeterminated colitis. Chronic inflomatory bowel...

  • Interleukin-21 (IL-21) Controls Inflammatory Pathways in the Gut. Fina, Daniele; Caruso, Roberta; Pallone, Francesco; Monteleone, Giovanni // Endocrine, Metabolic & Immune Disorders - Drug Targets;Dec2007, Vol. 7 Issue 4, p288 

    In both Crohn's disease (CD) and ulcerative colitis (UC), the major forms of inflammatory bowel diseases (IBD) in humans, the pathologic process consists of an aberrant local immune response to components of the bacterial microflora, due to abnormally strong effector cell activity that is poorly...

  • CARD4/NOD1 is not involved in inflammatory bowel disease. Zouali, H.; Lesage, S.; Merlin, F.; Cézard, J.-P.; Colombel, J.-F.; Belaiche, J.; Almer, S.; Tysk, C.; O'Morain, C.; Gassull, M.; Christensen, S.; Finkel, Y.; Modigliani, R.; Gower-Rousseau, C.; Macry, J.; Chamaillard, M.; Thomas, G.; Hugot, J.-P. // Gut;Jan2003, Vol. 52 Issue 1, p71 

    Background and aims: Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are complex genetic disorders. CARD15/NOD2, a member of the Ced4 superfamily which includes Apaf-1 and CARD4/NOD1, has recently been associated with genetic predisposition to CD...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics