Combined Fourier-transform infrared imaging and desorption electrospray-ionization linear ion-trap mass spectrometry for analysis of counterfeit antimalarial tablets

Ricci, Camilla; Nyadong, Leonard; Fernandez, Facundo M.; Newton, Paul N.; Kazarian, Sergei G.
January 2007
Analytical & Bioanalytical Chemistry;Jan2007, Vol. 387 Issue 2, p551
Academic Journal
This paper reports use of a combination of Fourier-transform infrared (FTIR) spectroscopic imaging and desorption electrospray ionization linear ion-trap mass spectrometry (DESI MS) for characterization of counterfeit pharmaceutical tablets. The counterfeit artesunate antimalarial tablets were analyzed by both techniques. The results obtained revealed the ability of FTIR imaging in non-destructive micro-attenuated total reflection (ATR) mode to detect the distribution of all components in the tablet, the identities of which were confirmed by DESI MS. Chemical images of the tablets were obtained with high spatial resolution. The FTIR spectroscopic imaging method affords inherent chemical specificity with rapid acquisition of data. DESI MS enables high-sensitivity detection of trace organic compounds. Combination of these two orthogonal surface-characterization methods has great potential for detection and analysis of counterfeit tablets in the open air and without sample preparation.


Related Articles

  • antimalarial (Major drug group).  // Royal Society of Medicine: Medicines;2002, p74 

    The article presents information on antimalarial drugs. These agents are used to treat or prevent malaria. Malaria is caused by infection of the red blood cells by a small organism called a protozoan, which is carried by several species of mosquito of the genus Anopheles. The synthetic chemical...

  • Malarone.  // Royal Society of Medicine: Medicines;2002, p346 

    This article presents information on Malarone, a proprietary, prescription-only compound preparation of the antimalarial proguanil hydrochloride together with the antiprotozoal atovaquone. It can be used in the prevention of malaria, and is available as tablets.

  • Maloprim.  // Royal Society of Medicine: Medicines;2002, p346 

    This article presents information on Maloprim, a proprietary, prescription-only compound preparation of the antibacterial and antimalarial dapsone and the antimalarial pyrimethanine. It can be used to prevent visitors to tropical regions from contracting malaria, and is available as tablets.

  • High mass accuracy and high mass resolving power FT-ICR secondary ion mass spectrometry for biological tissue imaging. Smith, Donald; Kiss, Andras; Leach, Franklin; Robinson, Errol; Paša-Tolić, Ljiljana; Heeren, Ron // Analytical & Bioanalytical Chemistry;Jul2013, Vol. 405 Issue 18, p6069 

    Biological tissue imaging by secondary ion mass spectrometry has seen rapid development with the commercial availability of polyatomic primary ion sources. Endogenous lipids and other small bio-molecules can now be routinely mapped on the sub-micrometer scale. Such experiments are typically...

  • Neuropsychiatric events during prophylactic use of mefloquine before travelling. van Riemsdijk, M. M.; Ditters, J. M.; Sturkenboom, M. C. J. M.; Tulen, J. H. M.; Ligthelm, R. J.; Overbosch, D.; Stricker, B. H. Ch. // European Journal of Clinical Pharmacology;Sep2002, Vol. 58 Issue 6, p441 

    Introduction. It has been suggested that neuropsychiatric events during use of mefloquine are more common in females than in males and are partly explained by the psychological stress of travelling. Therefore, we investigated neuropsychiatric events in females and males on mefloquine in the...

  • Ensuring quality and access for malaria diagnosis: how can it be achieved? Bell, David; Wongsrichanalai, Chansuda; Barnwell, John W. // Nature Reviews Microbiology;Sep2006 Supplement, Vol. 4, pS7 

    The replacement of conventional antimalarial drugs with high-cost, artemisinin-based alternatives has created a gap in the successful management of malaria. This gap reflects an increased need for accurate disease diagnosis that cannot be met by traditional microscopy techniques. The recent...

  • Malaria prophylaxis.  // Pulse;4/12/2004, Vol. 64 Issue 15, p82 

    Presents a chart of malaria prophylaxis for travelers. Key to regimens; Children's doses of antimalaria prophylactics; Children's doses of prophylactic Malarone.

  • Malarone. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p485 

    A definition of the term "Malarone," which refers to a brand-named antimalarial drug that contains proguanil with atovaquone, is presented.

  • Paludrine. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p583 

    A definition of the term "Paludrine" is presented. It refers to the brand name for proguanil, an antimalarial drug.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics