Paroxysmal hemicrania responding to topiramate

Cohen, A. S.; Goadsby, P. J.
January 2007
Journal of Neurology, Neurosurgery & Psychiatry;Jan2007, Vol. 78 Issue 1, p96
Academic Journal
Chronic paroxysmal hemicrania (CPH) is a rare primary headache syndrome, which is classified along with cluster headache and short-lasting unilateral neuralgiform headache attacks with conjunctival injection and tearing (SUNCT) as a trigeminal autonomic cephalalgia. CPH is exquisitely responsive to indomethacin so much so that the response is one of the current diagnostic criteria. The case of a patient with CPH, who had marked epigastric symptoms with indomethacin treatment and responded well to topiramate 150 mg daily, is reported. Cessation of topiramate caused return of episodes, and the response has persisted for 2 years. Topiramate may be a treatment option in CPH.


Related Articles

  • Headaches. Fuller, Geraint; Kaye, Claire // BMJ: British Medical Journal (International Edition);2/3/2007, Vol. 334 Issue 7587, p254 

    The article examines headaches. Different type of headaches include tension headaches, migraine, cluster headaches, and dangerous headaches such as meningitis, subarachnoid hemorrhage, and temporal arteritis. The article discusses the use of topiramate for the prevention of migraine, the British...

  • Treating hemicrania continua.  // Mayo Clinic on Headache;2005, p107 

    This article focuses on the effect of indomethacin on hemicrania continua headaches. Hemicrania continua headaches improve dramatically in response to the nonsteroidal anti-inflammatory drug. The response usually occurs within a few days. This drug can be used daily by people with hemicrania...

  • Hemicrania continua. Rapoport, Alan M.; Bigal, Marcello E. // Journal of Headache & Pain;Nov 2004 Supplement 2, Vol. 5, ps96 

    Hemicrania continua was described in 1984 by Sjastaad and Spierings as a unilateral, almost always side-locked headache that is continuous and fluctuating in intensity. There are added pain exacerbation periods of varying frequency, consisting of more severe headache, of at least moderate...

  • Strategies for the treatment of autonomic trigeminal cephalalgias. Leone, M.; Franzini, A.; D'Amico, D.; Grazzi, L.; Mea, E.; Curone, M.; Tullo, V.; Broggi, G.; D'Andrea, G.; Bussone, G. // Neurological Sciences;Oct2004 Supplement 3, Vol. 25, ps167 

    Trigeminal autonomic cephalalgias (TACs) are a group of primary headache syndromes characterised by two main clinical characteristics: pain and oculofacial autonomic phenomena. Three headache forms are grouped as TACs: cluster headache (CH), paroxysmal hemicrania (PH) and short-lasting...

  • The Coxibs, Selective Inhibitors of Cyclooxygenase-2. FitzGerald, Garret A.; Patrono, Carlo // New England Journal of Medicine;8/9/2001, Vol. 345 Issue 6, p433 

    The article provides information on nonsteroidal antiinflammatory drugs (NSAIDs). Although they are effective for the treatment of arthritis, menstrual pain and headache, the long-term use of NSAIDs is limited by gastrointestinal effects such as dyspepsia and abdominal pain and less often,...

  • Using indomethacin as a tocolytic. Vermillion, Stephen T.; Scardo, James A. // Contemporary OB/GYN;Jul2000, Vol. 45 Issue 7, p102 

    Assesses the use of indomethacin as a tocolytic. Pharmacology and efficacy of indomethacin; Discussion on the potential fetal and neonatal effects associated with its use; Guidelines that will assist the clinician in using indomethacin as an effective tocolytic while avoiding untoward effects.

  • Are Cox-2 drugs the second line option in indomethacin responsive headaches? Porta-Etessam, Jesús; Cuadrado, Marialuz; Rodríguez-Gómez, Octavio; García-Ptacek, Sara; Valencia, Cristina // Journal of Headache & Pain;Oct2010, Vol. 11 Issue 5, p405 

    Paroxysmal hemicrania and hemicrania continua are both indomethacin-responsive headaches. Although indomethacin use to be well tolerated, some patients developed gastrointestinal side effects. We report four cases of hemicrania continua and a patient suffering chronic paroxysmal hemicrania...

  • Indomethacin and Canine Lower Esophageal Sphincter Pressure. Mokka, Risto E. M.; Punto, Lauri; Kairaluoma, Matti I.; Larmi, T. K. I. // American Journal of Gastroenterology;Apr1977, Vol. 67 Issue 4, p366 

    Presents the study which investigates the effect of indomethacin administered rectally on the canine lower esophageal sphincter pressure. Aim of the conservative treatment of hiatal hermia; Materials and methods used in the study; Findings of the study.

  • Impairment of Gastric Ulcer Healing by Alendronate, a Nitrogen-Containing Bisphosphonate, in Rats. Kikuko Amagase; Shusaku Hayashi; Kaoru Nishikawa; Eitaro Aihara; Koji Takeuchi // Digestive Diseases & Sciences;Aug2007, Vol. 52 Issue 8, p1879 

    Abstract  Bisphosphonates such as alendronate have been developed as antiresorptive agents capable of treating diseases related to bone remodeling. In the present study, we examined the effect of alendronate on the healing of acetic acid-induced gastric ulcers in rats and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics