TITLE

Surveillance for Wilms tumour in at-risk children: pragmatic recommendations for best practice

AUTHOR(S)
Scott, R. H.; Walker, L.; Olsen, Ø. E.; Levitt, G.; Kenney, I.; Maher, E.; Owens, C. M.; Pritchard-Jones, K.; Craft, A.; Rahman, N.
PUB. DATE
December 2006
SOURCE
Archives of Disease in Childhood;Dec2006, Vol. 91 Issue 12, p995
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Most Wilms tumours occur in otherwise healthy children, but a small proportion occur in children with genetic syndromes associated with increased risks of Wilms tumour. Surveillance for Wilms tumour has become widespread, despite a lack of clarity about which children are at increased risk of these tumours and limited evidence of the efficacy of screening or guidance as to how screening should be implemented. Methods: The available literature was reviewed. Results: The potential risks and benefits of Wilms turnout surveillance are finely balanced and there is no clear evidence that screening reduces mortality or morbidity. Prospective evidence-based data on the efficacy of Wilms turnout screening would be difficult and costly to generate and are unlikely to become available in the foreseeable future. Conclusions: The following pragmatic recommendations have been formulated for Wilms tumour surveillance in children at risk, based on our review: (1) Surveillance should be offered to children at >5% risk of Wilms tumour. (2) Surveillance should only be offered after review by a clinical geneticist. (3) Surveillance should be carried out by renal ultrasonography every 3–4 months. (4) Surveillance should continue until 5 years of age in all conditions except Beckwith-Wiedemann syndrome, Simpson-Golabi-Behmel syndrome and some familial Wilms tumour pedigrees where it should continue until 7 years. (5) Surveillance can be undertaken at a local centre, but should be carried out by someone with experience in paediatric ultrasonography. (6) Screen-detected lesions should be managed at a specialist centre.
ACCESSION #
23528907

 

Related Articles

  • Nephroblastoma in adults. Clinical and histopathological features of two incidental Wilms' tumors. Wroński, Stanislaw; Marszałek, Andrzej // Central European Journal of Urology;Sep2009, Vol. 62 Issue 3, p198 

    Nephroblastoma (Wilms' tumor) - the most common malignant renal tumor in childhood is extremely rare in adults. Early diagnosis is difficult and usually made by pathologic examination of a surgical specimen. The possibility of successful treatment and therefore prognosis of nephroblastoma in...

  • Metanephric stromal tumor: An unusual pediatric renal neoplasm. Bajaj, Sunil K.; Misra, Ritu; Batra, Vineeta; Gupta, Rohini; Bagga, Deepak // Journal of Indian Association of Pediatric Surgeons;Jul-Sep2013, Vol. 18 Issue 3, p115 

    A renal tumor in a 14-month- old child, who was initially diagnosed as mesoblastic nephroma, but on review post surgery was diagnosed as hyper-differentiated metanephric stromal tumor, with its excellent prognostic outcome. An attempt is made to document imaging features that may enable one to...

  • Jubiläumskongress 100 Jahre Deutsche Sportmedizin 4.-6.10. 2012, Berlin. Zeman, Václav // Medicina Sportiva Bohemica et Slovaca;2012, Vol. 21 Issue 4, p205 

    No abstract available.

  • Air Pollution and Child Mortality: A Time-Series Study in Sao Paulo, Brazil. Conceicao, Gleice M.S.; Miraglia, Simone G.E.K.; Kishi, Humberto S.; Saldiva, Paulo H.N.; Singer, Julio M. // Environmental Health Perspectives Supplements;Jun2001 Supplement 3, Vol. 109, p347 

    Evaluates the correlation between air pollution and child mortality in Sao Paulo, Brazil. Effect of the gaseous fraction of urban air pollution on the health of children; Comparison between children and adults in the possibility of developing respiratory diseases; Implications of the results on...

  • TÄ›lesná zdatnost pacientů v dlouhodobé remisi nefroblastomu má obdobné vazby k rizikovým faktorům civilizačních chorob jako u běžné populace. Radvanský, Jiří; Slabý, Kryštof; Procházka, Michal; Radvanská, Jitka; Gilík, Jiří // Medicina Sportiva Bohemica et Slovaca;2008, Vol. 17 Issue 2, p58 

    Nephroblastoma is the most frequent abdominal cancer in children, mostly unilateral. Median age at diagnosis is 3 years, long term survival rate is 80-90%. Treatment involves nephrectomy, chemotherapy including cardiotoxic agents some treatment regimens and radiation therapy in advanced stages....

  • Reduced renal length and volume 20 years after very preterm birth. Keijzer-Veen, Mandy; Devos, Annick; Meradji, Morteza; Dekker, Friedo; Nauta, Jeroen; Heijden, Bert // Pediatric Nephrology;Mar2010, Vol. 25 Issue 3, p499 

    Intrauterine growth retardation is presumed to be associated with decreased renal size and impaired renal function as a result of stunted kidney development and nephron deficit. To study whether very preterm birth also affects renal size at young adulthood, we sonographically measured bipolar...

  • 3. Pediatric Dermatology.  // Journal of Cutaneous Medicine & Surgery;Sep/Oct2003, Vol. 7 Issue 5, p413 

    Discusses several research studies regarding cutaneous medicine and surgery in connection with pediatric dermatology. Determination of the association between BCG vaccination and age at vaccination with atopy development; Determination of the risk factors associated with the development of...

  • Clinical Image: A Severe Form of Gastroschisis. Mwenda, Aruyaru Stanley // Journal of Pakistan Medical Students;Apr-Jun2012, Vol. 2 Issue 2, p58 

    The article discusses the case of a 25-year-old pregnant Kenyan woman who complaed of lower abdominal pain and reduced fetal movements. Both intrauterine fetal death (IUFD) and polyhydramnio were detected via obstetric ultrasound. A macerated fetus with a severe kind of gastroschisis was...

  • Evaluation of Incidental Renal and Adrenal Masses.  // American Family Physician;01/15/2001, Vol. 63 Issue 2, p288 

    Provides information on the evaluation of incidental renal masses. Background on incidental renal masses; Criteria for ultrasound diagnosis; Referral requirement.

Share

Read the Article

Other Topics