Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough

Park, H.-K.; Oh, S.-Y.; Kim, T.-B.; Bahn, J.-W.; Shin, E.-S.; Lee, J.-E.; Oh, H.-B.; Kim, Y.-K.; Park, T.; Cho, S.-H.; Min, K.-U.; Kim, Y.-Y.
December 2006
Thorax;Dec2006, Vol. 61 Issue 12, p1070
Academic Journal
Background: Chronic cough is associated with increased sensitivity to inhaled capsaicin, and both tachykinins and their receptors play important roles in the cough reflex. However, associations between polymorphisms of the tachykinin receptor genes and cough sensitivity in patients with non-productive chronic cough have not been reported. Methods: Direct sequencing was used to identify single nucleotide polymorphisms (SNPs) in the genes for the neurokinin-1 and neurokinin-2 receptors (NK-1R and NK-2R, respectively). Informative non-synonymous SNPs were scored using the single base extension method for 312 patients with chronic cough and for 100 age matched healthy controls. The cough response to capsaicin was recorded for 312 patients with chronic cough, and the potential genetic association between cough sensitivity to capsaicin and the NK-1R and NK-2R genotypes was evaluated. Results: Two informative SNPs were identified in NK-2R (Gly231Glu and Arg375His), whereas no informative SNP was found in NK-1R. After adjusting for atopy, sex, age, and smoking, the prevalence of enhanced cough sensitivity to capsaicin was higher in the chronic cough patients with the 231Glu allele (p=0.004; OR 1.69 (95% CI 1.18 to 2.42)) and the 231Glu_375Arg haplotype (p=0.003; OR 1.71 (95% CI 1.20 to 2.24)]. Moreover, the lowest capsaicin concentration to cause five consecutive coughs (C5) was significantly lower in patients with 231Glu (mean (SD) 44.1 (53.2) v 60.9 (55.8) μM/l, p = 0.04) and those with 231Glu_375Arg (43.2 (52.7) v 69.6 (52.0) μM/l, p = 0.03). Conclusions: The results of this study suggest that NK-2R gene polymorphisms are involved in the enhanced cough sensitivity to capsaicin of patients with chronic cough.


Related Articles

  • Effect of Tiotropium on Cough Reflex Sensitivity in Acute Viral Cough. Dicpinigaitis, Peter V.; Spinner, Leah; Santhyadka, Ganesha; Negassa, Abdissa // Lung;Nov2008, Vol. 186 Issue 6, p369 

    Study Objectives Cough is the most common complaint for which patients in the United States seek medical attention. Few, if any, effective therapies exist for the most common form of acute cough, that due to viral upper respiratory tract infection (URI). The aim of this study was to evaluate the...

  • THAT'S HOT.  // Scholastic SuperScience;Apr2008, Vol. 19 Issue 7, p3 

    The article offers information on the Bhut Jolokia chili pepper variety, which has been discovered by scientists from the New Mexico State University as the world's hottest chili pepper.

  • Hot evolution.  // Discover;Nov99, Vol. 20 Issue 11, p40 

    Reports on the research done by Joshua Tewksbury of the University of Montana in Missoula on the capsaicin content of chili plants.

  • Hot Peppers are Cool.  // Science Teacher;Jan2004, Vol. 71 Issue 1, p14 

    Reports on capsaicin, a chemical that makes pepper hot. History of the pepper family; Usability of the chemical; Development of capsaicin.

  • Directed deterrence by capsaicin in chillies. Tewksbury, Joshua J.; Nabhan, Gary P. // Nature;7/26/2001, Vol. 412 Issue 6845, p403 

    Provides information on a study which examined the evolutionary significance of capsaicin in chillies. Method of the study; Results of the study; Conclusion of the study.

  • Involvement of the Melanocortin-1 Receptor in Acute Pain and Pain of Inflammatory but Not Neuropathic Origin. Delaney, Ada; Keighren, Margaret; Fleetwood-Walker, Susan M.; Jackson, Ian J. // PLoS ONE;2010, Vol. 5 Issue 9, p1 

    Background: Response to painful stimuli is susceptible to genetic variation. Numerous loci have been identified which contribute to this variation, one of which, MC1R, is better known as a gene involved in mammalian hair colour. MC1R is a G protein-coupled receptor expressed in melanocytes and...

  • Cough receptor sensitivity to capsaicin does not change after allergen bronchoprovocation in allergic asthma. Minoguchi, H.; Minoguchi, K.; Tanaka, A.; Matsuo, H.; Kihara, N.; Adachi, M. // Thorax;Jan2003, Vol. 58 Issue 1, p19 

    Background: The relationship between cough receptor sensitivity and eosinophilic inflammation of the airway in patients with asthma remains unclear. Methods: Eighteen patients with asthma sensitised to house dust mite (HDM) were enrolled in a randomised parallel group study. Patients with asthma...

  • capsicum oleoresin.  // Royal Society of Medicine: Medicines;2002, p136 

    This article provides information on capsicum oleoresin, a pungent extract from capsicum peppers. The active principle of these peppers, which are also used for culinary purposes as chilli and cayenne pepper, is capsaicin. Both capsicum resin and capsaicin are incorporated into medicines with...

  • Involvement of Tachykinins in Endotoxin-Induced Airway Hyperresponsiveness. Loeffler, B.S.; Arden, W.A.; Fiscus, R.R.; Lee, L.-Y. // Lung;1997, Vol. 175 Issue 4, p253 

    Inhaled endotoxin, lipopolysaccharide (LPS), has been shown to result in bronchial hyperresponsiveness (BHR) to endogenous bronchoconstrictive mediators such as histamine. To determine the role of sensory neuropeptides released from bronchopulmonary C-fibers in LPS-induced BHR, 24 guinea pigs...


Read the Article


Sign out of this library

Other Topics