TITLE

HIV-1 Replication Is Stimulated by Sodium Stibogluconate, the Therapeutic Mainstay in the Treatment of Leishmaniasis

AUTHOR(S)
Barat, Corinne; Zhao, Chenqi; Ouellette, Marc; Tremblay, Michel J.
PUB. DATE
January 2007
SOURCE
Journal of Infectious Diseases;1/15/2007, Vol. 195 Issue 2, p236
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Leishmaniasis is an important opportunistic disease among patients infected with human immunodeficiency virus (HIV)-1. The pentavalent antimony compound sodium stibogluconate is a drug of choice for the treatment of leishmaniasis. Because sodium stibogluconate acts as an inhibitor of phosphotyrosyl phosphatases and such inhibitors can promote HIV-1 replication, we tested the effect of this compound on virus gene expression. Using pseudotyped reporter viruses and fully infectious laboratory-adapted and clinical strains of HIV-1, we report that sodium stibogluconate induces an increase in HIV-1 transcription and virus replication in primary CD4+ T cells and in thymic histocultures. This activation is a slow process and appears to involve the transcription factors nuclear factor-κB and activator protein 1, as well as the Syk, Jun, and mitogenactivated protein kinase/extracellular signal-related kinase signal-transduction pathways. In addition, the effect seems to be partly mediated by a soluble factor. Altogether, these findings might reveal clinical implications for the treatment of leishmaniasis in HIV-1-infected patients.
ACCESSION #
23490260

 

Related Articles

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics