TITLE

Abnormal pontine activation in pathological laughing as shown by functional magnetic resonance imaging

AUTHOR(S)
Kosaka, H.; Omata, N.; Omori, M.; Shimoyama, T.; Murata, T.; Kashikura, K.; Takahashi, T.; Murayama, J.; Yonekura, Y.; Wada, Y.
PUB. DATE
December 2006
SOURCE
Journal of Neurology, Neurosurgery & Psychiatry;Dec2006, Vol. 77 Issue 12, p1376
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To explore the aetiology of pathological laughing, a 65-year-old woman with pathological laughing was examined by 3-T functional magnetic resonance imaging (fMRI) before and after treatment with drugs. Here, we report that the patient consistently showed exaggerated pontine activation during the performance of three tasks before treatment, whereas abnormal pontine activation was no longer found after successful treatment with the selective serotonin reuptake inhibitor, paroxetine. Our findings in this first fMRI study of pathological laughing suggest that serotonergic replacement decreases the aberrant activity in a circuit that involves the pons.
ACCESSION #
23489004

 

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