TITLE

Building Bridges with Biomarkers

AUTHOR(S)
Branca, Malorye A.
PUB. DATE
September 2006
SOURCE
Pharma DD: Tracking Discovery & Development;Sep/Oct2006, Vol. 1 Issue 2, p28
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article highlights biomarker discovery. It mentions that scientists at Bristol-Myers are uncertain on what they would discover or how they would utilize it when they started looking for markers of response to their Sprycel cancer drug. Those that are based on gene-expression analysis are cited as probably the most popular and most advanced types of genomic biomarkers.
ACCESSION #
23475286

 

Related Articles

  • Gene expression profiling in blood: new diagnostics in alcoholism and addiction? Mayfield, R Dayne; Harris, R Adron // Neuropsychopharmacology;Jan2009, Vol. 34 Issue 1, p250 

    The article reports on the new process of diagnostics in alcoholism and addiction involving gene expression and blood profiling. Early detection is the key to successful treatment that is why biomarkers with prognostic value in drug addiction field is an important area. The advances in genomics...

  • Validation of Simple Sequence Repeats Marker System in Different Genomic Groups of Musa sp. Mahanti, Kishor Kumar; Ravi Shankar, K. V.; Rekha, A. // Current Trends in Biotechnology & Pharmacy;Apr2015, Vol. 9 Issue 2, p157 

    An investigation was done to validate Simple Sequence Repeats (SSR) marker in 50 Musa accessions. All the accessions with exclusively AA genome showed only one allele of 733 bp, while accessions having only the BB genome lacked 733 bp allele but had the an allele of 652 bp. A total of 12 ABB...

  • Discovery of molecular subtypes in leiomyosarcoma through integrative molecular profiling. Beck, A. H.; Lee, C.-H.; Witten, D. M.; Gleason, B. C.; Edris, B.; Espinosa, I.; Zhu, S.; Li, R.; Montgomery, K. D.; Marinelli, R. J.; Tibshirani, R.; Hastie, T.; Jablons, D. M.; Rubin, B. P.; Fletcher, C. D.; West, R. B.; van de Rijn, M. // Oncogene;2/11/2010, Vol. 29 Issue 6, p845 

    Leiomyosarcoma (LMS) is a soft tissue tumor with a significant degree of morphologic and molecular heterogeneity. We used integrative molecular profiling to discover and characterize molecular subtypes of LMS. Gene expression profiling was performed on 51 LMS samples. Unsupervised clustering...

  • Integrative network-based Bayesian analysis of diverse genomics data. Wenting Wang; Baladandayuthapani, Veerabhadran; Holmes, Chris C.; Kim-Anh Do // BMC Bioinformatics;2013, Vol. 14 Issue Suppl 13, p1 

    Background: In order to better understand cancer as a complex disease with multiple genetic and epigenetic factors, it is vital to model the fundamental biological relationships among these alterations as well as their relationships with important clinical outcomes. Methods: We develop an...

  • An Integrative Genomics Approach to Biomarker Discovery in Breast Cancer. Hicks, Chindo; Asfour, Rozana; Pannuti, Antonio; Miele, Lucio // Cancer Informatics;2011, Issue 9, p185 

    Genome-wide association studies (GWAS) have successfully identified genetic variants associated with risk for breast cancer. However, the molecular mechanisms through which the identified variants confer risk or influence phenotypic expression remains poorly understood. Here, we present a novel...

  • Biomarker detection in the integration of multiple multi-class genomic studies. Shuya Lu; Jia Li; Chi Song; Kui Shen; Tseng, George C. // Bioinformatics;Feb2010, Vol. 26 Issue 3, p333 

    Motivation: Systematic information integration of multiple-related microarray studies has become an important issue as the technology becomes mature and prevalent in the past decade. The aggregated information provides more robust and accurate biomarker detection. So far, published meta-analysis...

  • Regulators of gene expression as biomarkers for prostate cancer. Willard, Stacey S.; Koochekpour, Shahriar // American Journal of Cancer Research;2012, Vol. 2 Issue 6, p620 

    Recent technological advancements in gene expression analysis have led to the discovery of a promising new group of prostate cancer (PCa) biomarkers that have the potential to influence diagnosis and the prediction of disease severity. The accumulation of deleterious changes in gene expression...

  • Integrative genomics analysis of chromosome 5p gain in cervical cancer reveals target over-expressed genes, including Drosha. Scotto, Luigi; Narayan, Gopeshwar; Nandula, Subhadra V.; Subramaniyam, Shivakumar; Kaufmann, Andreas M.; Wright, Jason D.; Pothuri, Bhavana; Mansukhani, Mahesh; Schneider, Achim; Arias-Pulido, Hugo; Murty, Vundavalli V. // Molecular Cancer;2008, Vol. 7, Special section p1 

    Background: Copy number gains and amplifications are characteristic feature of cervical cancer (CC) genomes for which the underlying mechanisms are unclear. These changes may possess oncogenic properties by deregulating tumor-related genes. Gain of short arm of chromosome 5 (5p) is the most...

  • Gene expression profile of cervical tissue compared to exfoliated cells: Impact on biomarker discovery. Steinau, Martin; Lee, Daisy R; Rajeevan, Mangalathu S; Vernon, Suzanne D; Ruffin, Mack T; Unger, Elizabeth R // BMC Genomics;2005, Vol. 6, p64 

    Background: Exfoliated cervical cells are used in cytology-based cancer screening and may also be a source for molecular biomarkers indicative of neoplastic changes in the underlying tissue. However, because of keratinization and terminal differentiation it is not clear that these cells have an...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics