SCREEN DREAMS: The Promise of Parallel Screening

Branca, Malorye A.
September 2006
Pharma DD: Tracking Discovery & Development;Sep/Oct2006, Vol. 1 Issue 2, p20
Academic Journal
The article focuses on parallel screening. The commitment of Merck Research Laboratories to parallel screening is via high-content screening (HCS). It mentions that genotoxicity is one use for HCS that is becoming the commonplace. A specialized new label-free screening approach built around proprietary Kinobeads is being offered by biotechnology company Cellzome.


Related Articles

  • Comparative Molecular Surface Analysis (CoMSA) for Virtual Combinatorial Library Screening of Styrylquinoline HIV-1 Blocking Agents. Niedbala, Halina; Polanski, Jaroslaw; Gieleciak, Rafal; Musiol, Robert; Tabak, Dominik; Podeszwa, Barbara; Bak, Andrzej; Palka, Anna; Mouscadet, Jean-Francois; Gasteiger, Johann; Le Bret, Marc // Combinatorial Chemistry & High Throughput Screening;Dec2006, Vol. 9 Issue 10, p753 

    We used comparative molecular surface analysis to design molecules for the synthesis as part of the search for new HIV-1 integrase inhibitors. We analyzed the virtual combinatorial library (VCL) constituted from various moieties of styrylquinoline and styrylquinazoline inhibitors. Since imines...

  • Evidence for the antifouling potentials of marine macroalgae Sargassum wightii. Iyapparaj, Palanisamy; Ramasubburayan, Ramasamy; Raman, Thulasi; Das, Narayana; Kumar, Pradeep; Palavesam, Arunachalam; Immanuel, Grasian // Advances in Natural & Applied Sciences;2012, Vol. 6 Issue 2, p153 

    Marine biofouling often cause significant damage to hulls of ships, underwater pipelines and other marine infrastructures. Biofilm bacterial load of test substrata at Chinnamuttom fisheries harbour, Southeast coast of India varied significantly with respect to substrata and exposure duration....

  • Poisonous Birds Are What They Eat. McKenzie, Aline // Ask;Apr2005, Vol. 4 Issue 4, p3 

    Presents information on pitohui bird, a poisonous bird found in New Guinea. Probable source of the poison; Clinical manifestations of their sting; Mystery that scientists are trying to solve.

  • Brands, costs and registration status of antimalarial drugs in the Kenyan retail sector. Amin, Abdinasir A.; Snow, Robert W. // Malaria Journal;2005, Vol. 4, p36 

    Background: Although an important source of treatment for fevers, little is known about the structure of the retail sector in Africa with regard to antimalarial drugs. This study aimed to assess the range, costs, sources and registration of antimalarial drugs in the Kenyan retail sector....

  • Study of Organic Honey from the Northeast of Portugal. Gomes, Teresa; Feás, Xesús; Iglesias, Antonio; Estevinho, Leticia M. // Molecules;Jul2011, Vol. 16 Issue 7, p5374 

    Concerns about traces of numerous toxic substances and authenticity have prompted consumer demand for honey that is certified as organic, based on strict ecological, natural principles and traceability. The present study aims to characterize organic honey samples (n = 73) from Northeast...

  • Predicting the Mechanical Properties of BHA-Li2O Composites Using Artificial Neural Networks. Celik, Hasan Huseyin; Gunduz, Oguzhan; Ekren, Nazmi; Ahmad, Zeeshan; Oktar, Faik Nuzhet // Journal of Biomaterials & Nanobiotechnology;Jan2011, Vol. 2 Issue 1, p98 

    In this study the mechanical properties of bovine hydroxyapatite (BHA)-Li2O composites are predicted using artificial neural networks (ANN) and then compared with obtained experimental values. BHA was mixed with lithium carbonate (Li2CO3) and sintered at various temperatures between...

  • ToxPi GUI: an interactive visualization tool for transparent integration of data from diverse sources of evidence. Reif, David M.; Sypa, Myroslav; Lock, Eric F.; Wright, Fred A.; Wilson, Ander; Cathey, Tommy; Judson, Richard R.; Rusyn, Ivan // Bioinformatics;Feb2013, Vol. 29 Issue 3, p402 

    Motivation: Scientists and regulators are often faced with complex decisions, where use of scarce resources must be prioritized using collections of diverse information. The Toxicological Prioritization Index (ToxPiâ„¢) was developed to enable integration of multiple sources of evidence on...

  • Prediction of bioactive compound activity against wood contaminant fungi using artificial neural networks. Vicente, Henrique; Roseiro, José C.; Arteiro, José M.; Neves, José; Caldeira, A. Teresa // Canadian Journal of Forest Research;Nov2013, Vol. 43 Issue 11, p985 

    Biopesticides based on natural endophytic bacteria to control plant diseases are an ecological alternative to chemical treatments. Bacillus species produce a wide variety of metabolites with biological activity like iturinic lipopeptides. This work addresses the production of biopesticides based...

  • Numerate's Small-Molecule Drug Engine Yields Pipeline, Partners. Boggs, Jennifer // BioWorld Today;3/26/2008, Vol. 19 Issue 59, p1 

    The article discusses the growing pipeline and partnering possibilities of Numerate Inc. after releasing its small-molecule engineering platform. The platform, which development started at Pharmix Corp. in Brisbane, California, refers to the drug engineering process that designs and optimizes...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics