TITLE

The Effect of Bacterial Contamination on Neointimal Hyperplasia in Vascular Grafts

AUTHOR(S)
Edwards, Norma M.; Claridge, Jeffrey A.; Shell IV, Dan H.; Handorf, Charles R.; Croce, Martin A.; Fabian, Timothy C.
PUB. DATE
December 2006
SOURCE
American Surgeon;Dec2006, Vol. 72 Issue 12, p1168
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Neointimal hyperplasia (NH) is the most significant contributing factor to long-term vascular graft failure. Inflammation is known to be important in its development; however, the role of bacterial infection is unclear. We examined the effect of contamination with common organisms on the development of NH in expanded polytetrafluoroethylene grafts. Thirty adult pigs were randomized into one of four groups: no infection, contamination with Staphylococcus aureus, mucin-producing Staphylococcus epidermidis, or Pseudomonas aeruginosa. An expanded polytetrafluoroethylene graft (6 mm x 3 cm) was placed as a common iliac artery interposition graft and was inoculated with 1-2 x 10s of the selected organism before closure. Grafts were explanted 6 weeks postoperatively. Microbiologic, histological, and morphometric evaluations were performed. All grafts were patent at the time of euthanasia. The mean areas of NH were 5.45 mm² in sterile grafts, 8.36 mm² in S. aureus, 7.63 mm² in S. epidermidis, and 11.52 mm² in P. aeruginosa grafts. Comparison of means via analysis of variance showed that P. aeruginosa grafts had significantly higher formation of NH than sterile grafts (P = 0.025). NH production in infected grafts appears to be organism specific and is significantly higher with P. aeruginosa than common Gram-positive organisms. Increased NH from subclinical infection may be a significant factor contributing to late graft failures.
ACCESSION #
23474048

 

Related Articles

  • Nonreinforced PTFE: Material of Choice for HD Access.  // Kidney;May/Jun98, Vol. 7 Issue 3, p117 

    Discusses the abstract of the research paper 'Reinforced versus nonreinforced polytetrafluoroethylene grafts for hemodialysis access,' by E.S. Schuman, B.A. Standage et al and published in a 1997 issue of the 'American Journal of Surgery.'

  • Routine Use of PTA Unwarranted in Treating Stenoses.  // Kidney;May/Jun98, Vol. 7 Issue 3, p117 

    Discusses the abstract of the research paper 'Prophylactic balloon angioplasty fails to prolong the patency of expanded polytetrafluoroethylene arteriovenous grafts: Results of a prospective randomized study,' by A.B. Lumsden, J. Macdonald et al and published in a 1997 issue of the 'Journal of...

  • The Healing of the Thin-Walled Expanded Polytetrafluoroethylene Vascular Graft. Takenaka, Kenji; Kholoussy, A. Mohsen; Yeng Yang; Kodellas, Lambros; Matsumoto, Teruo // Vascular Surgery;Nov/Dec1985, Vol. 19 Issue 6, p383 

    The objective of this experiment was to investigate the healing of thin-walled reinforced expanded polytetrafluoroethylene (PTFE) vascular graft (thin graft). In 12 dogs (30-35 kgm), a 4 cm segment of each common iliac artery was excised and replaced with an equal length of PTFE vascular graft,...

  • Renal vessel reconstruction in kidney transplantation using a polytetrafluoroethylene (PTFE) vascular graft. Mohamed H. Kamel; Anil A. Thomas; Ponnusamy Mohan; David P. Hickey // Nephrology Dialysis Transplantation;Apr2007, Vol. 22 Issue 4, p1030 

    Background. We report a rare experience in reconstructing short renal vessels in kidney transplantation using polytetrafluroethylene (PTFE) vascular grafts.Methods. The short renal vessels in three kidney grafts were managed by the interposition of PTFE vascular grafts. Two grafts were from...

  • Perigraft Seroma Presenting as Discharging Sinus and Spontaneous Exteriorization of Vascular Graft -- A Rare Entity Following Vascular Repair with PTFE Graft. BABU, ANNU; PANDEY, MANISH KUMAR; GUPTA, AMIT; RANJAN, PIYUSH; SINGHAL, MANEESH // Journal of Clinical & Diagnostic Research;Sep2015, Vol. 9 Issue 9, p15 

    Perigraft seroma presenting as discharging sinus and spontaneous exteriorization of vascular graft are rare complication of vascular injury repair with polytetrafluoroethylene (PTFE) grafts. We hereby report a case of young boy who presented with discharging sinuses and vascular graft coming out...

  • Commentary: The Hybrid Vascular Graft: A New Frontier in Arteriovenous Access for Dialysis or Just Another Graft? Jones, Robert G.; Inston, Nicholas G. // Journal of Endovascular Therapy (Sage Publications Inc.);Oct2015, Vol. 22 Issue 5, p786 

    The authors examine the hybrid vascular graft, a polytetrafluoroethylene (PTEE) graft with a reinforced nitinol section, which shows good patency for two years.

  • Which prosthesis is more resistant to vascular graft infection: polytetrafluoroethylene or Omniflow II biosynthetic grafts? Bozoglan, Orhan; Mese, Bulent; Eroglu, Erdinc; Elveren, Serdal; Gul, Mustafa; Celik, Ahmet; Yildirimdemir, Halil; Ciralik, Harun; Yasim, Alptekin // Surgery Today;Mar2016, Vol. 46 Issue 3, p363 

    Purpose: The aim of this study was to determine whether polytetrafluoroethylene grafts or Omniflow II biosynthetic grafts are more resistant to infection caused by Staphylococcus aureus. Methods: Sixty rats were divided into six groups. In Groups 1A, 1B and 1C, a polytetrafluoroethylene graft...

  • A SYNTHETIC VASCULAR CONDUIT (EXPANDED PTFE) FOR HEMODIALYSIS ACCESS-A PRELIMINARY REPORT. Pasternak, B. M. // Vascular Surgery;Mar/Apr1977, Vol. 11 Issue 2, p99 

    The short term follow up of the thirteen PTFE synthetic grafts placed in eleven patients for chronic hemodialysis is reported. PTFE graft appears to be a satisfactory alternative to a bovine graft for use as a subcutaneous arteriovenous conduit for hemodialysis. Its resistance to local infection...

  • The Influence of Supporting Rings on the Healing of the Ringed Expanded Polytetrafluoroethylene Vascular Graft. Takenaka, Kenji; Kholoussy, A. Mohsen; Yeng Yang; Emara, Medhat; Fusaro, James; Matsumoto, Teruo // Vascular Surgery;Sep/Oct1985, Vol. 19 Issue 5, p323 

    The influence of supporting rings on the healing of the ringed expanded polytetrafluoroethylene (ePTFE) vascular graft (ringed graft) was studied. In 12 dogs (32-42 kgm), a 4cm segment of each common iliac artery was excised and replaced with an equal length of 6mm ePTFE vascular graft. Ringed...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics