TITLE

In Vivo Mutagenic Effect of Very Low Dose Radiation

AUTHOR(S)
Sykes, Pamela J.; Day, Tanya K.; Swinburne, Sarah J.; Lane, Joanne M.; Morley, Alexander A.; Hooker, Antony M.; Bhat, Madhava
PUB. DATE
October 2006
SOURCE
Dose-Response;2006, Vol. 4 Issue 4, p309
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Almost all of our knowledge about the mutational effect of radiation has come from high dose studies which are generally not relevant to public exposure. The pKZ1 mouse recombination mutagenesis assay enables study of the mutational effect of very low doses of low LET radiation (μGy to cGy range) in a whole animal model. The mutational endpoint studied is chromosomal inversion which is a common mutation in cancer. We have observed 1) a non-linear dose response of induced inversions in pKZ1 mice exposed to a wide dose range of low LET radiation, 2) the ability of low priming doses to cause an adaptive response to subsequent higher test doses and 3) the effect of genetic susceptibility where animals that are heterozygous for the Ataxia Telangiectasia gene (Atm) exhibit different responses to low dose radiation compared to their normal litter-mates.
ACCESSION #
23463379

 

Related Articles

  • Radiation-induced versus endogenous DNA damage: possible effect of inducible protective responses in mitigating endogenous damage. Pollycove, Myron; Feinendegen, Ludwig E // Human & Experimental Toxicology;Jun2003, Vol. 22 Issue 6, p290 

    Ionizing radiation (IR) causes damage to DNA that is apparently proportional to absorbed dose. The incidence of radiation-induced cancer in humans unequivocally rises with the value of absorbed doses above about 300 mGy, in a seemingly linear fashion. Extrapolation of this linear correlation...

  • The PKZ1 Recombination Mutation Assay: A Sensitive Assay for Low Dose Studies. Sykes, P. J.; Morley, A. A.; Hooker, A. M. // Dose-Response;2006, Vol. 4 Issue 2, p91 

    The majority of mutation studies are performed at high doses of DNA damaging agents due to the insensitivity of most mutation assays. Extrapolation using a linear no-threshold (LNT) dose response model is then used to estimate the extent of possible DNA damage at lower doses. There is increasing...

  • Experimental Radio-Osteonecrosis of the Jaws. GOWGIEL, JOSEPH M. // Journal of Dental Research;Jan1960, Vol. 39 Issue 1, p176 

    The article discusses experimental radio-osteonecrosis in the jaws of monkeys, the dose-response relationship between fractionated irradiation and bone changes in the mandible and maxilla, and the pathogenesis of postirradiation osteonecrosis. The conclusion is that damage from this condition...

  • Preface. Cuttler, Jerry; Mitchel, Ron // Dose-Response;2006, Vol. 4 Issue 4, p255 

    A preface for the October 2006 issue of "Dose-Response" is presented.

  • Differential Expression of Oxidative Stress and Extracellular Matrix Remodeling Genes in Low- or High-Dose-Rate Photon-Irradiated Skin. Mao, Xiao Wen; Mekonnen, Tsehay; Kennedy, Ann R.; Gridley, Daila S. // Radiation Research;Aug2011, Vol. 176 Issue 2, p187 

    Changes in the expression of genes implicated in oxidative stress and in extracellular matrix (ECM) remodeling and selected protein expression profiles in mouse skin were examined after exposure to low-dose-rate or high-dose-rate photon irradiation. ICR mice received whole-body γγ rays to...

  • Perspectives: Dominant Lethal Mutations in the Honeybee: A Perspective 50 Years Later. Lee, William R. // Genetics;May2008, Vol. 179 Issue 1, p1 

    The article focuses on a study concerning the dominant lethal mutations in the honeybee. According to the author, the honeybee offered unique characteristics for answering specific questions on dominant lethals. He mentions that in the experiments, he exposed drones to gamma radiation and...

  • Chemoprevention by N-acetylcysteine of low-dose CT-induced murine lung tumorigenesis. Miller, Mark Steven; Moore, Joseph E.; Walb, Matthew C.; Kock, Nancy D.; Attia, Albert; Isom, Scott; McBride, Jennifer E.; Munley, Michael T. // Carcinogenesis;Feb2013, Vol. 34 Issue 2, p319 

    Data from the National Lung Screening Trial suggested that annual computed tomography (CT) screening of at-risk patients decreases lung cancer mortality by 20%. We assessed the effects of low-dose CT radiation in mice exposed to 4-(methylnitrosoamino)-1-(3-pyridyl)-1-butanone (NNK) to mimic the...

  • IB-MECA, an Adenosine A3 Receptor Agonist, Does Not Influence Survival of Lethally ?-Irradiated Mice. HOFER, M.; POSPÍŠIL, M.; DUŠEK, L.; HOFEROVÁ, Z.; KOMŮRKOVÁ, D. // Physiological Research;2012, Vol. 61 Issue 6, p649 

    In our previous studies, IB-MECA, an adenosine A3 receptor agonist, was found to stimulate proliferation of hematopoietic progenitor and precursor cells in mice. This property of IB-MECA was considered to be responsible for its ability to support regeneration of suppressed hematopoiesis after...

  • TNF-α and Microglial Hormetic Involvement in Neurological Health & Migraine. Kraig, Richard P.; Mitchell, Heidi M.; Christie-Pope, Barbara; Kunkler, Phillip E.; White, David M.; Tang, Ya-Ping; Langan, George // Dose-Response;2010, Vol. 8 Issue 4, p389 

    Environmental enrichment, i.e., increased intellectual, social, and physical activity makes brain more resilient to subsequent neurological disease. The mechanisms for this effect remain incompletely defined, but evidence shows tumor necrosis factor-alpha (TNF-α) is involved. TNF-α, at...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics