TITLE

Suppression of Neoplastic Transformation in Vitro by Low Doses of Low Let Radiation

AUTHOR(S)
Redpath, J. Leslie
PUB. DATE
October 2006
SOURCE
Dose-Response;2006, Vol. 4 Issue 4, p302
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
A major concern of exposure to low doses of radiation is the risk of cancer induction. Epidemiologic data are rarely powerful enough to accurately discriminate this risk at doses <10 cGy. In order to gain insight into events at these low doses, laboratory-based studies of relevant endpoints are required. One such endpoint is radiation-induced neoplastic transformation in vitro. Such studies can provide quantitative dose-response data, as well as insights into underlying cellular and molecular mechanisms. Data are presented that indicate that low doses of low LET radiation can suppress neoplastic transformation in vitro to levels below that seen spontaneously. Mechanisms involved include both the death of a subpopulation of cells prone to spontaneous neoplastic transformation and the induction of DNA repair. The relative contributions of these mechanisms is dose-dependent. The relevance of these observations to radiation risk estimation is discussed.
ACCESSION #
23463373

 

Related Articles

  • The RBE of 3.4 MeV α-particles and 0.565 MeV neutrons relative to 60Co γ-rays for neoplastic transformation of human hybrid cells and the impact of culture conditions. Frankenberg-Schwager, M.; Spieren, S.; Pralle, E.; Giesen, U.; Brede, H. J.; Thiemig, M.; Frankenberg, D. // Radiation Protection Dosimetry;Jan2010, Vol. 138 Issue 1, p29 

    The neoplastic transformation of human hybrid CGL1 cells is affected by perturbations from external influences such as serum batch and concentration, the number of medium changes during the 21-day expression period and cell seeding density. Nevertheless, for doses up to 1.5 Gy, published...

  • Effect of Radiotherapy on Non-Neoplastic and Malignant Prostate. Iczkowski, Kenneth A. // Open Pathology Journal;2009, Vol. 3, p64 

    Pathologists nowadays are frequently confronted with post-radiotherapy biopsies of the prostate. It is critical to recognize the changes of benign prostatic tissue with radiation effect, which include frequent acinar atrophy, acinar distortion, basal cell hyperplasia, decreased acinar/stromal...

  • Expression of matrix metalloproteinase-9 in the neoplastic and interstitial inflammatory infiltrate cells in the different histopathological types of esophageal cancer. Mroczko, Barbara; Kozłowski, Mirosław; Groblewska, Magdalena; Łukaszewicz, Marta; Nikliński, Jacek; Laudański, Jerzy; Chyczewski, Lech; Szmitkowski, Maciej // Folia Histochemica et Cytobiologica;2008, Vol. 46 Issue 4, p471 

    Metalloproteinase-9 (MMP-9) is the proteolytic enzyme degrading type IV collagen, and plays important role in the invasiveness and metastatic potential of tumor cells. The aim of the current study was to compare the association between the intensity of MMP-9 expression in neoplastic cells and in...

  • PET-CT in detection of meningeal metastasis in neuroblastoma. Chawla, Madhavi; Reddy, Ramamohan; Kumar, Rajender; Das, Chandan J.; Agarwala, Sandeep; Tiwari, Amar M.; Malhotra, Arun; Kumar, Rakesh // Pediatric Surgery International;Feb2009, Vol. 25 Issue 2, p211 

    Neoplastic meningitis is being recognized with increasing frequency in patients with cancer: the common causes being adenocarcinomas originating from the lung, stomach, breast, ovary, malignant melanoma, leukemia, lymphoma, Ewings sarcoma, rhabdomyosarcoma, retinoblastoma and primary CNS...

  • Acting alone. Novak, Kristine // Nature Reviews Cancer;Jan2004, Vol. 4 Issue 1, p3 

    Examines mechanisms of hormone-refractory (HR) prostate tumour growth. Drug therapy for prostate cancer; Charles Sawyer and colleagues' study showing that increased androgen-receptor (AR) expression is the defining factor in HR disease; Abilities of AR required for growth of HR tumours;...

  • Evaluation of the depth score of type V pit patterns in crypt orifices of colorectal neoplastic lesions. Onishi, Tomoko; Tamura, Satoru; Kuratani, Yoshinori; Onishi, Saburo; Yasuda, Nobufumi // Journal of Gastroenterology;2008, Vol. 43 Issue 4, p291 

    We developed and evaluated the clinical usefulness of a scoring system that subclassified type V i pit patterns. We studied 119 colon cancer lesions (pTis, n = 26; pT1, n = 93) and 22 tubular adenoma lesions with severe atypia in which a type V i pit pattern was visible under a stereomicroscope....

  • Expression of Claudin-7 Molecule in Canine Perianal GlandTumours. Jakab, Csaba; Rusvai, Miklós; Gálfi, Péter; Kulka, Janina // Acta Veterinaria Brno;Mar2010, Vol. 79 Issue 1, p127 

    The present study evaluated the expression of claudin-7 in 10 intact perianal gland and 67 hyperplastic and neoplastic lesions of the canine perianal (hepatoid) gland. The results have shown intense typical membrane expression of claudin-7 in intact perianal glands, hyperplasia, adenoma,...

  • Cannabinoids: Do they have a Role in Cancer Therapy? Wai Man Liu; Powles, Thomas Bartholomew // Letters in Drug Design & Discovery;Mar2006, Vol. 3 Issue 2, p76 

    Cannabinoids, the active components of the cannabis plant, have merit as an anti-emetic and appetite stimulant in people with cancer. Recently, interest in cannabinoids has increased since reports that cannabinoids have anti-tumour activity. Although the mechanisms underlying these effects have...

  • Clinicopathological Features of Superficial Depressed-Type Colorectal Neoplastic Lesions. Hayakawa, Makoto; Shimokawa, Kuniyasu; Kusugami, Kazuo; Sugihara, Makoto; Morooka, Yutaka; Fujita, Takayoshi; Nakamura, Motosuke; Nishio, Yuji; Maeda, Kiyotaka; Ando, Takafumi; Peek, Richard M. // American Journal of Gastroenterology;Apr1999, Vol. 94 Issue 4, p944 

    We performed this study to analyze the endoscopic findings, dissecting microscopic features, and p53 immunostaining in superficial depressed-type (depressed) colorectal neoplastic lesions. METHODS: Dissecting stereomicroscopy was used to ascertain the size and pit pattern of lesions removed by...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics