TITLE

Methods developed for SELEX

AUTHOR(S)
Gopinath, Subash Chandra Bose
PUB. DATE
January 2007
SOURCE
Analytical & Bioanalytical Chemistry;Jan2007, Vol. 387 Issue 1, p171
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
SELEX (systematic evolution of ligands by exponential enrichment) is a process that involves the progressive purification from a combinatorial library of nucleic acid ligands with a high affinity for a particular target by repeated rounds of partitioning and amplification. With the development of aptamer technology over the last decade, various modified SELEX processes have arisen that allow various aptamers to be developed against a wide variety of molecules, irrespective of the target size. In the present review, the separation methods used in such SELEX processes are reviewed.
ACCESSION #
23460823

 

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