Temperature gradient focusing for microchannel separations

Shackman, Jonathan Jonathan G. Shackman & Matthew S. Munson & Jonathan G.; Munson, Matthew S.; Ross, David
January 2007
Analytical & Bioanalytical Chemistry;Jan2007, Vol. 387 Issue 1, p155
Academic Journal
The article describes the use of temperature gradient focusing (TGF) for microchannel separations. TGF is based upon balancing analytes' electrophoretic mobilities against a bulk flow containing hydrodynamic and electroosmotic flow components. It works by balancing the electrophoretic motion of analyte molecules against the bulk flow of solution through a separation channel. The electrophoretic velocity gradient is ensured by applying a temperature gradient along the length of the channel.


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