mRNA transport to and translation in neuronal dendrites

Wu, Chia-wen K.; Zeng, Fanyi; Eberwine, James
January 2007
Analytical & Bioanalytical Chemistry;Jan2007, Vol. 387 Issue 1, p59
Academic Journal
Transport of mRNA is an important biological process in all cells that sets up gradients of translated protein from the site of mRNA docking and translation. Neurons are highly polarized cells where the targeted movement of RNAs and local translation at that site have been shown to be integral to the proper functioning of the neuron. Indeed, this specialized biological function for localized RNAs in particular neurons may in part confer a selective advantage on these cells such that they “out-compete” others in the race to establish synaptic connectivity. In this mini-review we highlight some of the salient features of RNA targeting and translation in neurons.


Related Articles

  • The antibiotic viomycin traps the ribosome in an intermediate state of translocation. Ermolenko, Dmitri N.; Spiegel, P. Clint; Majumdar, Zigurts K.; Hickerson, Robyn P.; Clegg, Robert M.; Noller, Harry F. // Nature Structural & Molecular Biology;Jun2007, Vol. 14 Issue 6, p493 

    During protein synthesis, transfer RNA and messenger RNA undergo coupled translocation through the ribosome's A, P and E sites, a process catalyzed by elongation factor EF-G. Viomycin blocks translocation on bacterial ribosomes and is believed to bind at the subunit interface. Using fluorescent...

  • IFN-γ overcomes low responsiveness of myeloid dendritic cells to CpG DNA. Uchijima, Masato; Nagata, Toshi; Aoshi, Taiki; Koide, Yukio // Immunology & Cell Biology;Feb2005, Vol. 83 Issue 1, p92 

    Dendritic cells (DC) are professional APC that have an extraordinary capacity to prime naive T cells. It has been reported that human DC subsets express distinct toll-like receptor (TLR), which influences their function. In mice, we observed that plasmocytoid DC (pDC) express a higher level of...

  • RNA decay back in play. Peebles, Carol L.; Finkbeiner, Steven // Nature Neuroscience;Sep2007, Vol. 10 Issue 9, p1083 

    The article discusses the postsynaptic activity-induced arc mRNA which is a target for rapid degradation by the nonsense-mediated decay (NMD) pathway. This research has focused on the roles of activity dependent transcription and translation and on dendritic mRNA localization and protein...

  • Nuclear mRNA on the move. Noble, Kristen N.; Wente, Susan R. // Nature Cell Biology;Jun2010, Vol. 12 Issue 6, p525 

    Innovations in live-cell microscopy and single-molecule analysis have allowed a new direct view of nuclear messenger RNA dynamics. A new study extends previous analyses of mRNA-protein intranuclear transport and links this critical step to the kinetics of moving through nuclear pore complexes....

  • Following translation by single ribosomes one codon at a time. Jin-Der Wen; Lancaster, Laura; Hodges, Courtney; Zeri, Ana-Carolina; Yoshimura, Shige H.; Noller, Harry F.; Bustamante, Carlos; Tinoco Jr., Ignacio // Nature;4/3/2008, Vol. 452 Issue 7187, p598 

    We have followed individual ribosomes as they translate single messenger RNA hairpins tethered by the ends to optical tweezers. Here we reveal that translation occurs through successive translocation-and-pause cycles. The distribution of pause lengths, with a median of 2.8 s, indicates that at...

  • SUMOylation Is Required for Glycine-Induced Increases in AMPA Receptor Surface Expression (ChemLTP) in Hippocampal Neurons. Jaafari, Nadia; Konopacki, Filip A.; Owen, Thomas F.; Kantamneni, Sriharsha; Rubin, Philip; Craig, Tim J.; Wilkinson, Kevin A.; Henley, Jeremy M. // PLoS ONE;Jan2013, Vol. 8 Issue 1, Special section p1 

    Multiple pathways participate in the AMPA receptor trafficking that underlies long-term potentiation (LTP) of synaptic transmission. Here we demonstrate that protein SUMOylation is required for insertion of the GluA1 AMPAR subunit following transient glycine-evoked increase in AMPA receptor...

  • mRNA binding protein staufen 1-dependent regulation of pyramidal cell spine morphology via NMDA receptor-mediated synaptic plasticity. Lebeau, Geneviève; DesGroseillers, Luc; Sossin, Wayne; Lacaille, Jean-Claude // Molecular Brain;2011, Vol. 4 Issue 1, p22 

    Staufens (Stau) are RNA-binding proteins involved in mRNA transport, localization, decay and translational control. The Staufen 1 (Stau1) isoform was recently identified as necessary for the protein synthesis-dependent late phase long-term potentiation (late-LTP) and for the maintenance of...

  • Synaptic plasticity: Unmasked: dendritic mRNA dynamics. Whalley, Katherine // Nature Reviews Neuroscience;Mar2014, Vol. 15 Issue 3, p138 

    The article discusses the dynamics of dendritic mRNA and the effects of local translation of proteins through neuronal stimulation. It refers to two studies which reveal the complex process that unmasked the mRNA through neuronal activity. The findings indicate that beta-actin mRNA is present in...

  • Evolutionary conservation of components of the protein translocation complex. Hartmann, Enno; Sommer, Thomas // Nature;2/17/1994, Vol. 367 Issue 6464, p654 

    Studies the evolutionary conservation of components of the protein translocation complex. Requirements for the protein translocation into the mammalian endoplasmic reticulum; Key component of the protein export apparatus of bacteria; Determination of the sequences.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics