TITLE

Efficacy of emergent transcatheter transplantation of stem cells for treatment of acute myocardial infarction (TCT-STAMI)

AUTHOR(S)
Ge, J.; Li, Y.; Qian, J.; Shi, J.; Wang, O.; Niu, Y.; Fan, B.; Liu, X.; Zhang, S.; Sun, A.; Zou, Y.
PUB. DATE
December 2006
SOURCE
Heart;Dec2006, Vol. 92 Issue 12, p1764
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: To study whether emergent intracoronary autologous bone marrow cell transplantation (BMT) is applicable for the treatment of acute myocardial infarction (AMI). Methods: 20 patients admitted within 24 h after the onset of a first AMI were randomly allocated to receive intracoronary autologous BMT (n = 10) or bone marrow supernatant (controls, n = 10) immediately alter primary percutaneous coronary intervention. Left ventricular ejection fraction (LVEF), left ventricular end diastolic internal diameter (LVDd) and myocardial perfusion defect scores were examined respectively by echocardiography and single-photon emission computed tomography at one week and six months after AMI. Results: From one week to six months after AMI, LVEF was enhanced from mean 53.8 (SD 9.2)% to 58.6 (9.9)% (p <0.05) in the BMT group but was unchanged in the control group (58.2 (7.5)% v56.3 (3.5)%, p > 0.05); LVDd remained unchanged (52.5 (2.8) v 52.1(3.2) mm, p > 0.05) in the BMT group but was significantly enlarged in the control group (50.4 (6.0) v 55.2 (7.1) mm, p < 0.05). Additionally, myocardial perfusion defect scores decreased from 21(11) to 13 (10) (p < 0.01) in the BMT group but were unchanged in the control group (20 (14) v 17(15), p > 0.05). Conclusion: Emergent intracoronary transplantation of bone marrow mononuclear cells after AMI is practicable, and it improved cardiac function, prevented myocardial remodelling and increased myocardial perfusion at six months' follow up.
ACCESSION #
23356385

 

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