Assessing the Ability of Topiramate to Improve the Daily Activities of Patients With Migraine

Brandes, Jan Lewis; Kudrow, David B.; Rothrock, John F.; Rupnow, Marcia F. T.; Fairclough, Diane L.; Greenberg, Steven J.
October 2006
Mayo Clinic Proceedings;Oct2006, Vol. 81 Issue 10, p1311
Academic Journal
OBJECTIVE: To assess the impact of topiramate on the daily activities of patients with migraine. PATIENTS AND METHODS: We performed a randomized, double-blind, placebo-controlled multicenter trial initiated on March 1, 2001, and completed on April 4, 2002. Patient-reported data from the Migraine Specific Questionnaire (MSQ) and the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) were collected at baseline and at weeks 8, 16, and 26 from an intent-to-treat population receiving either topiramate, 50, 100, or 200 mg/d, or placebo. Two activity-related MSQ domains (role restrictive [MSQ-RR] and role prevention [MSQ-RP]) and 2 activity-related SF-36 domains (role physical [SF36-RP] and vitality [SF36-VT]) were the prospectively designated secondary outcome measures. The changes in MSQ and SF-36 scores for each treatment group were calculated by measuring the area under the curve from week 8 (the beginning of the maintenance period) through week 26 of the double-blind phase, relative to the prospective baseline. A mixed-effect piecewise linear regression model was used to estimate average domain score over time. RESULTS: Patients receiving topiramate, 100 or 200 mg/d, had significantly reduced mean monthly (28-day) migraine frequency (P=.008 and P<.001, respectively) compared with placebo, but not patients receiving topiramate, 50 mg/d (P=.48). Topiramate significantly improved mean MSQ-RR domain scores (50 mg/d [P=.02], 100 mg/d [P<.001], and 200 mg/d [P<.001]) and mean MSQ-RP domain scores (50 mg/d [P=.007], 100 mg/d [P=.001], and 200 mg/d [P=.002]) vs placebo. Topiramate, 100 and 200 rag/d, significantly improved mean SF36-RP domain scores vs placebo (P=.02). Topiramate (all doses) improved SF36-VT domain scores, although not significantly vs placebo. Changes in prospectively designated domain scores were significantly correlated with changes in mean monthly migraine frequency (P≤.001 [MSQ domains], P≤.002 [SF-36 domains]). CONCLUSION: Patient-reported migraine-specific outcomes measured by the MSQ-RR and MSQ-HP domains improved significantly for those receiving topiramate (all doses) vs placebo. The SF36-RP domain scores improved significantly for patients receiving 100 or 200 mg/d of topiramate. Improvements in all 4 prospectively selected MSQ and SF-36 domains were significantly correlated with decreases in mean monthly migraine frequency.


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