Oral Contraceptive Use as a Risk Factor for Premenopausal Breast Cancer: A Meta-analysis

Kahlenborn, Chris; Modugno, Francesmary; Potter, Douglas M.; Severs, Walter B.
October 2006
Mayo Clinic Proceedings;Oct2006, Vol. 81 Issue 10, p1290
Academic Journal
OBJECTIVE: To perform a meta-analysis of case-control studies that addressed whether prier oral contraceptive (OC) use is associated with premenopausal breast cancer. METHODS: We searched the MEDLINE and PubMed databases and bibliography reviews to identify case-control studies of OCs and premenopausal breast cancer published in or after 1980. Search terms used included breast neoplasms, oral contraceptives, contraceptive agents, and case-control studies. Studies reported In all languages were included. Thirty-four studies were identified that met inclusion criteria. Two reviewers extracted data from original research articles or additional data provided by study authors. We used the DerSimonian-Laird method to compute pooled odds ratios (ORs) and confidence Intervals (CIs) and the Mantel-Haenszel test to assess association between OC use and cancer. RESULTS: Use of OCs was associated with an Increased risk of premenopausal breast cancer in general (OR, 1.19; 95% CI, 1.09–1.29) and across various patterns of OC use. Among studies that provided data on nulliparous and parous women separately, OC use was associated with breast cancer risk In both parous (OR, 1.29; 95% CI, 1.20–1.40) and nulliparous (OR, 1.24; 95% CI, 0.92–1.67) women. Longer duration of use did not substantially alter risk in nulliparous women (OR, 1.29; 95% CI, 0.85–1.96). Among parous women, the association was stronger when OCs were used before first full-term pregnancy (FFTP) (OR, 1.44; 95% CI, 1.28–1.62) than after FFTP (OR, 1.15; 95% CI, 1.06–1.26). The association between OC use and breast cancer risk was greatest for parous women who used OCs 4 or more years before FFTP (OR, 1.52; 95% CI, 1.26–1.82). CONCLUSION: Use of OCs is associated with an increased risk of premenopausal breast cancer, especially with use before FFTP In parous women.


Related Articles

  • Breast cancer and lifestyle. Bharath, R. // Indian Journal of Cancer;Jul-Sep2011, Vol. 48 Issue 3, p296 

    The author reflects on the studies that using oral contraceptive pills (OCP) increases the incidence of breast cancer. The author states that the incidence of breast cancer seems to increase mildly during OCP use but it is not evident. The author cites that the use of OCP depends on different...

  • SON LOS ANTICONCEPTIVOS ORALES UN FACTOR DE RIESGO PARA EL DESARROLLO DE CÁNCER DE MAMA? Leal, F. José; Vargas, S. Francisco; Taladriz, R. Cristián // Revista Chilena de Obstetricia y Ginecología;2007, Vol. 72 Issue 2, p89 

    Background: One of the most controversial associations regarding the use of oral contraceptives has been the possibility of increasing risk of developing breast cancer. Objective: To determine if the available evidence supports that association. Methods: We analyzed 5 articles of a total of 12...

  • Mayo Clinic Proceedings. Cerhan, James R. // Mayo Clinic Proceedings;Oct2006, Vol. 81 Issue 10, p1287 

    The author reflects on the association of the oral contraceptive usage to breast cancer risks. The author emphasized the from the perspective of epidemiology and public health, the proper handling of the epidemiology of oral contraceptives use and health outcomes in both a beneficial and a...

  • NEWS ABOUT THE PILL AND BREAST CANCER RISK. Gold, Sunny Sea // Glamour;Feb2007, Vol. 105 Issue 2, p102 

    The article reports that a study has found the taking oral contraceptives may increase the risk of breast cancer before age 50 by between 20 and 50%. The rise in risk is actually quite small, from 1.5 to 2%. Doctors note that the Pill has other benefits, like reducing the risk of ovarian and...

  • Oral contraceptive use and kidney cancer risk among women: evidence from a meta-analysis. Huan Liu; Xing-Chun Wang; Guang-Hui Hu; Tian-Bao Huang; Yun-Fei Xu // International Journal of Clinical & Experimental Medicine;2014, Vol. 7 Issue 11, p3954 

    Previous studies have investigated the relationship between oral contraceptives (OCs) use and kidney cancer risk. However, they yielded inconsistent results. To our knowledge, a comprehensive assessment of the association between OC and kidney cancer risk has not been reported. Hence, we...

  • Injectable and Oral Contraceptive Use and Cancers of the Breast, Cervix, Ovary, and Endometrium in Black South African Women: Case-Control Study. Urban, Margaret; Banks, Emily; Egger, Sam; Canfell, Karen; O'Connell, Dianne; Beral, Valerie; Sitas, Freddy // PLoS Medicine;Mar2012, Vol. 9 Issue 3, p1 

    Background: Oral contraceptives are known to influence the risk of cancers of the female reproductive system. Evidence regarding the relationship between injectable contraceptives and these cancers is limited, especially in black South Africans, among whom injectable contraceptives are used more...

  • ORAL CONTRACEPTIVES AND BREAST CANCER. Johnson, Kenneth H.; Millard, Peter S. // Journal of Family Practice;Oct1996, Vol. 43 Issue 4, p340 

    This article focuses on a study that was conducted to analyze the role of oral contraceptives as a risk factor of breast cancer. Since their introduction in the 1960's, the safety of oral contraceptives (OCs) has been widely debated. For example, OCs increase the risk of thromboembolism, but...

  • Breast cancer and the pill. Kubba, A. A. // Journal of the Royal Society of Medicine;Jun2003, Vol. 96 Issue 6, p280 

    The article discusses the role of the birth control pill in the development of breast cancer in women. There is biological evidence that estrogens, particularly estradiol, is a factor in breast cancer pathogenesis. It is observed that although it is unlikely that the pill may cause breast...

  • Newer oral contraceptive pill does not increase risk of breast cancer.  // BMJ: British Medical Journal (International Edition);11/2/2002, Vol. 325 Issue 7371, p978 

    Discusses whether oral contraceptive use increases the risk of breast cancer. Information on analysis of more than 50 studies with more than 150,000 patients which found a slight increase in the risk of breast cancer with previous oral contraceptive use; How the risk was lower for patients who...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics