TITLE

Delayed thrombin generation is not associated with fibrinopeptide formation during prolonged cardiopulmonary bypass with hirudin anticoagulation

AUTHOR(S)
Belway, D.; Rubens, F. D.; Henley, B.; Babaev, A.; Mesana, T.
PUB. DATE
September 2006
SOURCE
Perfusion;Sep2006, Vol. 21 Issue 5, p259
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Patients with heparin-induced thrombocytopenia urgently requiring surgery with cardiopulmonary bypass (CPB) present a unique management challenge that must be addressed by the use of alternative anticoagulants. Although clinical success with the direct thrombin inhibitor hirudin has been reported, there is sparse information in the literature supporting the efficacy of this drug as an anti-thrombotic to prevent fibrin formation during CPB. In this report, we describe the efficacy of this drug to prevent thrombin-mediated fibrin formation during CPB.
ACCESSION #
23259298

 

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