TITLE

Asthma exacerbations ∙ 4: Prevention

AUTHOR(S)
Fitzgerald, J. M.; Gibson, P. G.
PUB. DATE
November 2006
SOURCE
Thorax;Nov2006, Vol. 61 Issue 11, p992
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Asthma exacerbations are common. They account for a significant morbidity and contribute a disproportionate amount to the cost of asthma management. The optimal strategies for the prevention of asthma exacerbations include the early introduction of anti-inflammatory treatment–most commonly, low dose inhaled corticosteroids. This should be coupled with a structured education programme which has a written action plan as an integral component. Where patients continue to be poorly controlled, the addition of a long acting β agonist should be considered. The latter should not be used as monotherapy and should always be used with inhaled corticosteroids. Atopic patients with a history of repeated exacerbations, especially if they are steroid dependent and with a raised IgE, may be considered as potential candidates for omalizumab. In the early stages of an asthma exacerbation, doubling the dose of inhaled corticosteroids has been shown to be ineffective. The ideal strategy for the management of worsening asthma in patients on combination treatment, especially salmeterol and fluticasone, is uncertain. There is an emerging body of evidence for strategies on how to prevent progression to an exacerbation in patients taking a combination of budesonide and formoterol.
ACCESSION #
23259081

 

Related Articles

  • Adverse Drug Reactions in Patients with Bronchial Asthma. Cukic, Vesna; Ustamujic, Aida; Lovre, Vladimir // Materia Socio Medica;2010, Vol. 22 Issue 2, p99 

    Adverse reactions to drugs are very common in everyday medical practice. Adverse drug reaction (ADR) is defined as any noxious, unintended and undesired effect to a drug that is administrated in standard doses by the proper route for the purpose of prophylaxis, diagnosis, or treatment. Some drug...

  • The FIRES Within. Gorman, Christine; Park, Alice // Life Extension;Jul2004, Vol. 10 Issue 7, p46 

    Focuses on the causes and complications of inflammation. Role of inflammation in infection prevention; Onset of heart attacks, colon cancer, Alzheimer's disease and other diseases from inflammation; Benefits from anti-inflammatory drugs; Disease prevention. INSET: OUCH!.

  • WHAT ARE THE DIFFERENT DRUGS SUPPOSED TO DO? Brostoff, Jonathan; Gamlin, Linda // Asthma: The Complete Guide;1999, p334 

    This section describes various types of asthma drugs. Corticosteroid drugs are designed to mimic a hormone called cortisol which is produced naturally by the body. Sodium cromoglycate and nedocromil sodium are two types of cromoglycate drugs. Both are believed to work at an early stage of the...

  • Intermittent therapy effective for mild persistent asthma.  // Journal of Family Practice;Jul2005, Vol. 54 Issue 7, p578 

    This article examines whether continuous therapy with anti-inflammatory drugs improves outcomes for patients with mild persistent asthma. Intermittent therapy, as measured by the outcomes that matter, is as effective as continuous therapy with oral zafirlukast or inhaled budesonide for patients...

  • Warning on analgesics and asthma.  // Australian Nursing Journal;Oct96, Vol. 4 Issue 4, p12 

    Describes the National Asthma Campaign's warning against the use of non-steroidal anti-inflammatory pain relievers. Finding that the analgesics may trigger asthma in people who already have the condition; Need to read labels on the analgesics carefully; Contact information.

  • Anti-inflammatory properties of desipramine and fluoxetine. Roumestan, Caroline; Michel, Alain; Bichon, Florence; Portet, Karine; Detoc, Maëlle; Henriquet, Corinne; Jaffuel, Dany; Mathieu, Marc // Respiratory Research;2007, Vol. 8, p35 

    Background: Antidepressants are heavily prescribed drugs and have been shown to affect inflammatory signals. We examined whether these have anti-inflammatory properties in animal models of septic shock and allergic asthma. We also analysed whether antidepressants act directly on peripheral cell...

  • Nedocromil: A new agent for the treatment of asthma. Keenan, Jeph M. // American Family Physician;10/1/1994, Vol. 50 Issue 5, p1059 

    Investigates the use of nedocromil sodium as an anti-inflammatory agent for the treatment of mild to moderate asthma. Pharmacodynamics; Pharmacokinetics; Toxicity; Side effects; Clinical experience; Clinical indications and dosage; Management issues.

  • Pharmacological Activities of Dodonaea viscosa: A Perspective Review. Rajeswari V., Devi; S., Gajalakshmi; P., Jayanthi; S., Vijayalakshmi // Journal of Pharmacy Research;Oct2011, Vol. 4 Issue 10, p3331 

    India possess a rich tradition of plant-based knowledge on healthcare systems. Medicinal plants were the richest source of India with many traditional uses. Many of the pharmacological and Pharmacognostical studies of the medicinal plants revealed their active application in the field of...

  • Reduced Risk of Upper Gastrointestinal Ulcer Complications With Celecoxib, A Novel COX-2 Inhibitor. Goldstein, Jay L.; Silverstein, Fred E.; Agrawal, Naurang M.; Hubbard, Richard C.; Kaiser, June; Maurath, Clement J.; Verburg, Kenneth M.; Geis, G. Steven // American Journal of Gastroenterology;Jul2000, Vol. 95 Issue 7, p1681 

    OBJECTIVE: The aim of this study was to assess the rate of upper gastrointestinal (UGI) ulcer complications (bleeding, perforation, or gastric outlet obstruction) associated with celecoxib, a specific COX-2 inhibitor, compared with the rate associated with nonspecific, nonsteroidal...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics