TITLE

Predictors of pulmonary exacerbations in patients with cystic fibrosis infected with multi-resistant bacteria

AUTHOR(S)
Block, J. K.; Vandemheen, K. L.; Tullis, E.; Fergusson, D.; Doucette, S.; Haase, D.; Berthiaume, Y.; Brown, N.; Wilcox, P.; Bye, P.; Bell, S.; Noseworthy, M.; Pedder, L.; Freitag, A.; Paterson, N.; Aaron, S. D.
PUB. DATE
November 2006
SOURCE
Thorax;Nov2006, Vol. 61 Issue 11, p969
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: This study examined characteristics of adult and adolescent patients with cystic fibrosis (CF) to determine factors associated with an increased risk of pulmonary exacerbations. Methods: 249 patients with CF infected with multidrug resistant bacteria were recruited and prospectively followed for up to 4.5 years until they experienced a pulmonary exacerbation severe enough to require intravenous antibiotics. Multivariable regression analyses were used to compare the characteristics of patients who experienced an exacerbation with those who did not. Results: 1 24 of the 249 patients (50%) developed a pulmonary exacerbation during the first year and 154 (62%) experienced an exacerbation during the 4.5 year study period. Factors predictive of exacerbations in a multivariable survival model were younger age (OR 0.98, 95% Cl 0.96 to 0.99), female sex (OR 1 .45, 95% CI 1 .07 to 1 .95), lower forced expiratory volume in 1 second (FEV1) (OR 0.98, 95% CI 0.97 to 0.99), and a previous history of multiple pulmonary exacerbations (OR 3.16, 95% CI 1 .93 to 5.17). Chronic use of inhaled corticosteroids was associated with an increased risk of exacerbation (OR 1 .92, 95% Cl 1 .00 to 3.71) during the first study year. Conclusions: Patients who experience pulmonary exacerbations are more likely to be younger, female, using inhaled steroids, have a lower FEV1, and a history of multiple previous exacerbations. It is hoped that knowledge of these risk factors will allow better identification and closer monitoring of patients who are at high risk of exacerbations.
ACCESSION #
23259076

 

Related Articles

  • Predicting the risk of atherosclerosis in patients with cystic fibrosis - rationale and design of a prospective cohort study. Mądry, Edyta; Nowak, Jan; Wykrętowicz, Andrzej; Wenska-Chyży, Ewa; Miśkiewicz-Chotnicka, Anna; Walkowiak, Jarosław // Journal of Medical Science;2015, Vol. 84 Issue 2, p113 

    The project "Risk of atherosclerosis in cystic fibrosis in relation to the exogenous and endogenous factors that influence the course of the disease" ranked first in the OPUS2 Competition, as announced in May 2012 by the Polish National Science Center. The total value of the grant is 198,580 PLN...

  • Biofilm Formation Inhibition of Multidrug-Resistant of Clinical Isolates Pseudomonas aeruginosa by Lactoferrin. Elsawy, Abdelrahman; Almehdar, Hussein; Redwan, Elrashdy M. // Australian Journal of Basic & Applied Sciences;Jan2013, Vol. 7 Issue 1, p129 

    Chronic infection with Pseudomonas aeruginosa is a leading cause of morbidity and mortality for human especially nosocomial and cystic fibrosis patients, despite high doses of antibiotics used to cure the various diseases of this organism. These infections are chronic because P. aeruginosa...

  • Intracellular survival of Burkholderia cepacia complex in phagocytic cells. Valvano, Miguel A. // Canadian Journal of Microbiology;Sep2015, Vol. 61 Issue 9, p607 

    Burkholderia cepacia complex (Bcc) species are a group of Gram-negative opportunistic pathogens that infect the airways of cystic fibrosis patients, and occasionally they infect other immunocompromised patients. Bcc bacteria display high-level multidrug resistance and chronically persist in the...

  • Gastrointestinal Manifestations of Cystic Fibrosis. Kelly, Thomas; Buxbaum, James // Digestive Diseases & Sciences;Jul2015, Vol. 60 Issue 7, p1903 

    Gastrointestinal symptoms of cystic fibrosis are the most important non-pulmonary manifestations of this genetic illness. Pancreatic manifestations include acute and chronic pancreatitis as well as pancreas insufficiency resulting in malnutrition. Complications in the gastrointestinal lumen are...

  • Newborn CF screening "economically beneficial.".  // PharmacoEconomics & Outcomes News;11/4/2006, Issue 515, p6 

    The article discusses research being done on the cost-effectiveness of different neonatal medical screening strategies for cystic fibrosis. It references a study by H. M. Dankert et al published in the September 2006 issue of the journal "Pediatrics." According to researchers, newborn cystic...

  • CFTR expression and organ damage in cystic fibrosis. Tizzano, Eduardo F.; Buchwald, Manuel // Annals of Internal Medicine;Aug95, Vol. 123 Issue 4, p305 

    Outlines possible causes of organ damage in cystic fibrosis. Rate of mediated chloride secretion in the epithelium inferred from the level of expression of the defective gene; Type of mutation that alters function of the cystic fibrosis transmembrane regulator; Anatomical traits of the affected...

  • Psychosocial Adaptation and Adherence Among Adults With CF: A Delicate Balance. Findler, Liora; Shalev, Keren; Barak, Asher // Rehabilitation Counseling Bulletin;Jan2014, Vol. 57 Issue 2, p90 

    Based on Moos and Holahan’s “Coping With Chronic Illness and Disability” model, we examined the contribution of medical impairment, illness perception, sense of coherence (SOC), relationship with the professional team, and adherence to treatment to the psychosocial adaptation...

  • Diverticulitis. Pfeifer, J. // Acta Chirurgica Iugoslavica;2008, Vol. 55 Issue 3, p97 

    Diverticular disease produces a wide range of Eclinical presentations varying from minimal clinical discomfort to life-threatening complications. Often there is a considerable discrepancy between clinical, radiologic, endoscopic and pathologic findings. Diverticulosis is a quite common disease...

  • Risk Stratification of Patients Presenting with Syncope. Ebell, Mark H. // American Family Physician;6/1/2012, Vol. 85 Issue 11, p1051 

    The article addresses the risk of a serious outcome or death in patients with syncope. Information on clinical decision rules for syncope is given. In one study, 7.6% of the 529 patients admitted to a British emergency department had a serious outcome or died within a month. These serious...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sign out of this library

Other Topics