Recognition and management of neuropsychiatric complications in Parkinson's disease

Ferreri, Florian; Agbokou, Catherine; Gauthier, Serge
December 2006
CMAJ: Canadian Medical Association Journal;12/5/2006, Vol. 175 Issue 12, p1545
Academic Journal
Parkinson's disease is primarily considered a motor disease characterized by rest tremor, rigidity, bradykinesia and postural disturbances. However, neuropsychiatric complications, including mood and anxiety disorders, fatigue, apathy, psychosis, cognitive impairment, dementia, sleep disorders and addictions, frequently complicate the course of the illness. The pathophysiologic features of these complications are multifaceted and include neuropathophysiologic changes of a degenerative disease, exposure to antiparkinsonian treatments and emotional reactions to having a disabling chronic illness. Changes in mental status have profound implications for the well-being of patients with Parkinson's disease and of their caregivers. Treatment is often efficacious but becomes a challenge in advanced stages of Parkinson's disease. In this article, we review the key clinical features of neuropsychiatric complications in Parkinson's disease as well as what is known about their epidemiologic characteristics, risk factors, pathophysiologic features and management.


Related Articles

  • Demenz und Depression determinieren Pflegebedürftigkeit bei M. Parkinson. Riedel, O.; Dodel, R.; Deuschl, G.; Förstl, H.; Henn, F.; Heuser, I.; Oertel, W.; Reichmann, H.; Riederer, P.; Trenkwalder, C.; Wittchen, H.U. // Der Nervenarzt;Aug2011, Vol. 82 Issue 8, p1012 

    Background: Parkinson's disease (PD) is frequently accompanied by dementia or depression which can aggravate the clinical picture of the disease and increase the risk of care dependency (CD). Little is known about the associations between PD, these neuropsychiatric comorbidities and CD in...

  • Association between fatigue and other motor and non-motor symptoms in Parkinson's disease patients. Solla, Paolo; Cannas, Antonino; Mulas, Cesare; Perra, Silvia; Corona, Andrea; Bassareo, Pier; Marrosu, Francesco // Journal of Neurology;Feb2014, Vol. 261 Issue 2, p382 

    Although fatigue is a common non-motor symptom in patients affected by Parkinson's disease (PD), its association with motor and other non-motor symptoms is still largely unclear. We assessed fatigue in PD patients studying the possible association with motor and non-motor symptoms. Eighty-one PD...

  • Parkinsonism with excessive daytime sleepiness. Baumann, Christian; Ferini-Strambi, Luigi; Waldvogel, Daniel; Werth, Esther; Bassetti, Claudio // Journal of Neurology;Feb2005, Vol. 252 Issue 2, p139 

    Background Parkinsonian patients with excessive day- time sleepiness (EDS), hallucinations, REM sleep behavior disorder (RBD), short mean sleep latencies, and sleep-onset REM periods (SOREMP) on multiple sleep latency tests (MSLT) have been re- ported. In these patients a narcolepsy-like...

  • Markers of neurodegeneration in idiopathic rapid eye movement sleep behaviour disorder and Parkinson's disease. Postuma, R. B.; Gagnon, J. F.; Vendette, M.; Montplaisir, J. Y. // Brain: A Journal of Neurology;Dec2009, Vol. 132 Issue 12, p3298 

    Idiopathic rapid eye movement sleep behaviour disorder is an important risk factor in the development of Parkinson's disease. Numerous potential predictive markers of Parkinson's disease may present before motor symptoms emerge, but testing of these markers in rapid eye movement sleep behaviour...

  • Perception of sleep: Subjective versus objective sleep parameters in patients with Parkinson’s disease in comparison with healthy elderly controls. Happe, Svenja; Klösch, Gerhard; Lorenzo, Josè; Kunz, Dieter; Penzel, Thomas; Röschke, Joachim; Himanen, S.-L.; Gruber, Georg; Zeitlhofer, Josef // Journal of Neurology;Aug2005, Vol. 252 Issue 8, p936 

    Introduction Subjective sleep perception, as measured against objective parameters such as those obtained by polysomnography, have not been examined thoroughly to date. Little is known about subjective sleep perception in patients with chronic somatic diseases. Patients and methods Patients with...

  • REM Sleep Behavior Disorder and Biomarkers of Neurodegenerative Disease. Nirenberg, Melissa J. // Neurology Alert;Jul2011, Vol. 29 Issue 11, p83 

    IN RECENT YEARS, THERE HAS BEEN A GROWING RECOGNITION that non-motor manifestations of Parkinson's disease (PD) and related disorders develop years -- or decades -- before the onset of motor symptoms. This "premotor stage" of PD is characterized by symptoms such as constipation, anxiety,...

  • Sleep problems in Parkinson's disease: a community-based study in Norway. Svensson, Elisabeth; Beiske, Antoine G.; Loge, Jon H†vard; Beiske, Kornelia K.; Sivertsen, B&›slash;rge // BMC Neurology;2012, Vol. 12 Issue 1, p71 

    Background: The purpose of this study was to examine the prevalence of sleep problems in a community-based sample of patients with Parkinson's disease (PD) in Norway, and their associated factors. Methods: 176 consecutive PD outpatients (41% females) were included in a study of non-motor...

  • The Relationship between Parkinson's Disease and Dementia A study using Proton NMR Imaging Parameters. Besson, J. A. O.; Mutch, W. J.; Smith, F. W.; Corrigan, F. M. // British Journal of Psychiatry;Oct85, Vol. 147, p380 

    The value of the spin lattice relaxation time (T1) obtained during nuclear magnetic resonance imaging of the brain was studied in patients with idiopathic Parkinson's disease, with and without dementia. T1 increases significantly in the basal ganglia and cerebral white matter of the demented and...

  • Parkinson�s disease and dementia. Padovani, A.; Costanzi, C.; Gilberti, N.; Borroni, B. // Neurological Sciences;May2006 Supplement 1, Vol. 27, ps40 

    Parkinson�s disease (PD) is one of the most common neurodegenerative disorders, affecting about 1% of the population over the age of 60. In addition to motor abnormalities, there are several non-motor signs and symptoms that may create a considerable burden for patients and care-givers....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics