Clinical Pharmacology

December 1998
Clinical & Investigative Medicine;Dec98 Supplement, Vol. 21, pS8
Academic Journal
The article presents a study which was designed for children with relapsed or refractory malignancies to determine the toxicities, pharmacokinetics, tolerability and monitoring guidelines for amifostine in the pediatric population. Close monitoring of the patients' general status, blood pressure, serum calcium and serum magnesium are necessary. The main toxicities of amifostine in pediatrics are similar to adults.


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