TITLE

Clinical Pharmacology

PUB. DATE
December 1998
SOURCE
Clinical & Investigative Medicine;Dec98 Supplement, Vol. 21, pS8
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article presents a study which was designed for children with relapsed or refractory malignancies to determine the toxicities, pharmacokinetics, tolerability and monitoring guidelines for amifostine in the pediatric population. Close monitoring of the patients' general status, blood pressure, serum calcium and serum magnesium are necessary. The main toxicities of amifostine in pediatrics are similar to adults.
ACCESSION #
23222466

 

Related Articles

  • Pharmacokinetics of Oral and Intravenous Clinafloxacin. Randinitis, E.J.; Brodfuehrer, J.; Vassos, A.B. // Drugs;Dec1999 Supplement 2, Vol. 58 Issue 6, p252 

    Evaluates the safety, tolerability and pharmacokinetics of oral and intravenous clinafloxacin in the single and multiple dose range. Materials and methods; Results and discussion.

  • Atazanavir: A Viewpoint by Robert L. Murphy. Murphy, Robert L. // Drugs;2003, Vol. 63 Issue 16, p1694 

    Focuses on features of the drug atazanavir. Favorable pharmacokinetic properties of atazanavir; Tolerability of the drug; Resistance profile of atazanavir

  • Pharmacokinetics and Tolerability of a New Hydroxyethyl Starch (HES) Specification [HES (130/0.4)] after Single-Dose Infusion of 6% or 10% Solutions in Healthy Volunteers. Waitzinger, J.; Bepperling, F.; Pabst, G.; Opitz, J.; Müller, M.; François Baron, J. // Clinical Drug Investigation;1998, Vol. 16 Issue 2, p151 

    Objective: To investigate the pharmacokinetic profile and tolerability of a single-dose infusion of the new hydroxyethyl starch (HES) specification, HES (130/0.4), 6% and 10% solutions in healthy volunteers. Study Design: In an open, randomised, single-dose, parallel-group study, 12 healthy...

  • Recognize significant drug interactions to prevent toxicity. Kuznar, Wayne // Dermatology Times;Nov97, Vol. 18 Issue 11, p47 

    Recognizes the need to familiarize with significant drug interactions in order to prevent threats of toxicity. Disadvantage of failure to recognize the systemic effect of drugs; Significance of thorough assessment of patients; Mechanism of actions of drugs.

  • A Prospective, Double-blinded, Crossover Study to Determine the Equivalence of the Serum Levels and the Peak Level Toxicity of Diphenylhydantoin (EptoinR). BHUVANESHWARI, S.; CHANDY, SUJITH; KUMAR, SUDHIR // Journal of Clinical & Diagnostic Research;Jun2012, Vol. 6 Issue 5, p783 

    Context: In India, phenytoin is often prescribed as twice daily or thrice daily dosage schedules. In the West, this practice has been changed to a once daily regimen in most of the cases. Can we in India follow suit? Is our physical and genetic make up with regards to the phenytoin...

  • Safety, effectiveness, and pharmacokinetics of adalimumab in children with polyarticular juvenile idiopathic arthritis aged 2 to 4 years. Kingsbury, Daniel; Bader-Meunier, Brigitte; Patel, Gina; Arora, Vipin; Kalabic, Jasmina; Kupper, Hartmut // Clinical Rheumatology;Oct2014, Vol. 33 Issue 10, p1433 

    The objective of this study was to assess the safety of adalimumab in patients aged 2 to <4 years old or ≥4 years old weighing <15 kg with moderately to severely active polyarticular juvenile idiopathic arthritis (JIA). Clinical effectiveness and pharmacokinetics (PK) of adalimumab were...

  • Atazanavir: A Viewpoint by Peter J. Piliero. Piliero, Peter J. // Drugs;2003, Vol. 63 Issue 16, p1694 

    Reports on the clinical development of the drug atazanavir, a novel azapeptide HIV-1 protease inhibitor. Administration of the drug once in a day; Tolerability of the drug; Occurrence of lipodystrophy in clinical trials of the drug.

  • Dopamine Uptake Changes Associated with Cocaine Self-Administration. Oleson, Erik B.; Talluri, Sanjay; Childers, Steven R.; Smith, James E.; Roberts, David C. S.; Bonin, Keith D.; Budygin, Evgeny A. // Neuropsychopharmacology;Apr2009, Vol. 34 Issue 5, p1174 

    The present study was designed to reveal the relationship between cocaine-induced dopamine uptake changes and patterns of cocaine self-administration observed under a fixed-ratio schedule. Cocaine was intravenously infused into anesthetized rats, according to inter-infusion intervals obtained...

  • TOLERANCE. TATUM IV, WILLIAM O.; KAPLAN, PETER W.; JALLON, PIERRE // Epilepsy A to Z: A Concise Encyclopedia;2009, p340 

    An encyclopedia entry for "tolerance" is presented. Drug tolerance involves the drug's diminished pharmacologic effectiveness when used at a constant dose. Decreased effectiveness with the reappearance or increased frequency of seizures are the clinical manifestations of antiepileptic drug (AED)...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics