TITLE

Expanding the pathway

AUTHOR(S)
Alderton, Gemma
PUB. DATE
December 2006
SOURCE
Nature Reviews Cancer;Dec2006, Vol. 6 Issue 12, p903
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article reports on the discovery of atypical cadherin Fat, an upstream regulator. After the introduction, maximum attention in the Salvador-Warts-Hippo growth-regulating pathway has generated. The Salvador-Warts-Hippo pathway restricts organ size by confining cell growth and proliferation, and by activating apoptosis. With the usage of D.melanogaster eye and wing discs as models for tissue growth, the loss of the tumor suppressor Fat persuades tissue overgrowth and unperturbed cell cycling.
ACCESSION #
23211078

 

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