Expanding the pathway

Alderton, Gemma
December 2006
Nature Reviews Cancer;Dec2006, Vol. 6 Issue 12, p903
Academic Journal
The article reports on the discovery of atypical cadherin Fat, an upstream regulator. After the introduction, maximum attention in the Salvador-Warts-Hippo growth-regulating pathway has generated. The Salvador-Warts-Hippo pathway restricts organ size by confining cell growth and proliferation, and by activating apoptosis. With the usage of D.melanogaster eye and wing discs as models for tissue growth, the loss of the tumor suppressor Fat persuades tissue overgrowth and unperturbed cell cycling.


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