Short-term lifestyle modification alters circulating biomarkers of endothelial health in sedentary, overweight adults

Turk, James R.; Sun, Grace Y.; Guilford, Brianne L.; Toedebusch, Brian W.; McClanahan, Matt W.; Thomas, Tom R.; Rector, R. Scott
October 2006
Applied Physiology, Nutrition & Metabolism;Oct2006, Vol. 31 Issue 5, p512
Academic Journal
Obesity and inactivity are associated with endothelial dysfunction that may contribute to the development of atherosclerosis. We examined the effects of a short-term lifestyle intervention on circulating biomarkers of endothelial health. Nineteen overweight or obese (mean body mass index (BMI): 28.9 ±0.7 kg/m2) men and women underwent 6 weeks of body mass reduction induced by moderate energy restriction (~750 kcal/d; 1 kcal = 4.184 kJ) and aerobic training (~400 kcal/d). Fasting serum samples were collected at baseline and after reduction in body mass (week 6) to assess concentrations of nitrotyrosine (NT), secretory phospholipase A2 (sPLA2), and soluble intracellular adhesion molecule-1 (sICAM-1). Body mass was significantly reduced from 81.3 ±2.8 to 77.3 ±2.6 kg (p < 0.05). Circulating concentrations of NT and sICAM-1 were significantly reduced with treatment (~25% and ~10%, respectively), whereas sPLA2 levels were significantly elevated (~45%). Elevations in sPLA2 were negatively correlated with changes in NT (r = –0.58, p = 0.047); reductions in NT did not correlate significantly with reductions in sICAM-1. It appears that circulating markers of endothelial health are susceptible to short-term exercise interventions with modest reduction in body mass, and such a lifestyle modification may improve endothelial health by reducing protein nitration products and cellular adhesion.


Related Articles

  • Good neighbors. Ryan, Pat // Functional U;Jul2005, Vol. 3 Issue 4, p20 

    Deals with weight management for older adults in the U.S. Association of appearance with one's lifestyle; Estimated percentage of adults who are overweight.

  • Be healthy (don't just think healthy). Crain, Esther // Self;Apr2003, Vol. 25 Issue 4, p194 

    Presents four fundamental methods for women to achieve a healthy lifestyle. Influence of information overload on the mind's tendency to constantly evaluate the benefits of foods and exercises; Recommendation to focus on two health programs that are realistic with individual goals; Acceptance of...

  • Employers weigh in on obesity risks. Roberts, Sally // Business Insurance;11/17/2003, Vol. 37 Issue 46, p4 

    Recognizing the direct and indirect effect that obesity has on their companies' bottom lines, more employers are encouraging healthier lifestyles within the workplace by implementing a variety of weight management and exercise programs for employees. Some employers are now expanding on those...

  • Treatment for overweight and obesity in adult populations: a systematic review and meta-analysis. Peirson, Leslea; Douketis, James; Ciliska, Donna; Fitzpatrick-Lewis, Donna; Ali, Muhammad Usman; Raina, Parminder // CMAJ Open;2014, Vol. 2 Issue 4, pE306 

    Background: Obesity is a major public health issue. This review updates the evidence on the effectiveness of behavioural and pharmacologic treatments for overweight and obesity in adults. Methods: We updated the search conducted in a previous review. Randomized trials of primary care--relevant...

  • Body Composition Changes in Adult Females after Lifestyle Intervention Are Influenced by the NYD-SP18 Variant. Suchánek, Pavel; Lánská, Věra; Hubáček, Jaroslav Alois; Lánská, V?ra; Hubá?ek, Jaroslav Alois // Central European Journal of Public Health;Nov2015 Supplement, Vol. 23, pS19 

    Aim: The study focuses on the analysis of the possible relationship between a common NYD-SP18 (rs6971091, G>A) gene polymorphism and weight loss after lifestyle intervention (combined dietary intake and physical activity) in overweight/obese females.Methods: We...

  • Has the Tide Turned in Obesity Battle? Kufahl, Pamela // Club Industry;Feb2010, Vol. 26 Issue 2, p6 

    The article reports on the obesity rate in the U.S. It is said that the government and media have always been encouraging Americans to have good nutrition and exercise to fight against obesity. It is noted that the obesity rate has decreased in which there are still suggestions from Centers for...

  • New weight-loss strategy.  // Cortlandt Forum;1/25/2006, Vol. 19 Issue 1, p19 

    The article reports on the recommendation of two anti-obesity medications in the U.S. Exercise is considered the mechanism of action that promote weight loss. University of Pennsylvania researchers suggested to individuals interested to loss weight that they should exercise and take sibutramine...

  • WEIGHT LOSS BULLETIN. Roberson, Laura // Men's Health;Mar2011, Vol. 26 Issue 2, p40 

    The article discusses research related to weight loss. According to a Mayo Clinic research, losing just a few pounds can expand arteries. Dutch researchers have found that planning responses to hunger may help a person lose fat faster. Researcher Wayne Miller, who studied exercise attitudes...

  • Programas de redução de peso via web: uma revisão. Torreglosa, Camila Ragne; Galante, Andréa Polo; Lobo, Alexandre Rodrigues; Colli, Célia // Demetra: Food, Nutrition & Health / Alimentação, Nutrição & ;2014, Vol. 9 Issue 1, p163 

    Introduction: The prevalence of obesity in the adult population is a public health concern. Pharmacological, surgical and behavioral therapies are consensual, but when they are not associated with changes in lifestyle are often ineffective in the long term. Web programs for weight loss are an...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics