Method optimization for determination of selected perfluorinated alkylated substances in water samples

González-Barreiro, Carmen; Martínez-Carballo, Elena; Sitka, Andrea; Scharf, Sigrid; Gans, Oliver
December 2006
Analytical & Bioanalytical Chemistry;Dec2006, Vol. 386 Issue 7/8, p2123
Academic Journal
In recent years perfluorinated alkylated substances (PFAS) have appeared as a new class of global pollutant. Besides being an industrially important group of compounds, PFAS are regarded as highly toxic and extraordinarily persistent chemicals that pervasively contaminate human blood and wildlife throughout the world. They are therefore regarded as PBT (persistent, bioaccumulative, and toxic) chemicals. Two comprehensive methods have been developed for determination of eleven of the most environmentally relevant PFAS (seven perfluoroalkylcarboxylates, two perfluoroalkylsulfonates, and two perfluoroctanesulfonamides) in aqueous samples. The compounds were isolated by liquid–liquid extraction (LLE) and solid-phase extraction (SPE), and identification and quantification of the target analytes were achieved by liquid chromatography–electrospray ionization–tandem mass spectrometry (LC–ESI–MS–MS). With LLE detection limits ranged from 0.26 to 0.62 ng L−1 for enrichment of 900-mL water samples; recovery of PFAS with a carbon chain longer than C7 was excellent (80–93%). With SPE, carboxylates with carbon chains


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