A case of exacerbation of ulcerative colitis induced by combination therapy with PEG- interferon α-2b and ribavirin

Watanabe, T.; Inoue, M.; Harada, K.; Homma, N.; Uchida, M.; Ogata, N.; Funada, R.; Hasegawa, K.; Soga, K.; Shibasaki, K.
November 2006
Gut;Nov2006, Vol. 55 Issue 11, p1682
Academic Journal
The article focuses on the case regarding an exacerbation of ulcerative colitis induced by combination therapy with PEG- interferon and ribavirin. This case involves a man with chronic hepatitis C presented with diarrhea and bloody stools in July 2003. It was found through a biopsy that the lesion confirmed the diagnosis and treatment was initiated with mesalazine. Moreover, a case of ulcerative colitis caused by the combination therapy in PEG-IFN and ribavirin for hepatitis C.


Related Articles

  • RATIONALE FOR CANCER PREVENTION STRATEGIES IN HIGH-RISK ULCERATIVE COLITIS. Campbell, F. C.; Maxwell, R. J. // Surgeon (Edinburgh University Press);Apr2009, Vol. 7 Issue 2, p96 

    Colorectal cancer (CRC) is the most feared long-term complication in patients with ulcerative colitis (UC) and Crohn's colitis. Surveillance by colonoscopy and serial biopsy is conducted to identify patients most likely to benefit from potentially curative surgery. Within this paradigm, patients...

  • Interfering with interferons in inflammatory bowel disease. Ghosh, S.; Chaudhary, R.; Carpani, M.; Playford, R. // Gut;Aug2006, Vol. 55 Issue 8, p1071 

    The article discusses the use of interferons for the treatment of inflammatory bowel disease. Interferons show antitumor and antiviral activities. In inflammatory bowel diseases such as Crohn's disease and ulcerative colitis, there is an increase in plasma and tissue concentrations of...

  • Possible role of REG lα protein in ulcerative colitis and colitic cancer. Sekikawa, A.; Fukui, H.; Fujii, S.; Nanakin, A.; Kanda, N.; Uenoyoma, Y.; Sawabu, T.; Hisatsune, H.; Kusaka, T.; Ueno, S.; Nakase, H.; Seno, H.; Fujimori, T.; Chiba, T. // Gut;Oct2005, Vol. 54 Issue 10, p1437 

    Background and aims: Although regenerating gene (REG) lα protein may be involved in the inflammation and carcinogenesis in the gastrointestinal tract, its pathophysiological role in ulcerative colitis (UC) and the resulting colitic cancer remains unclear. We investigated expression of the REG...

  • Peginterferon/ribavirin.  // Reactions Weekly;11/2/2013, Issue 1476, p27 

    The article presents case studies of three chronic hepatitis C patients who developed inflammatory bowel disease after taking ribavirin and peginterferon.

  • Comparative tight junction protein expressions in colonic Crohn's disease, ulcerative colitis, and tuberculosis: a new perspective. Das, Prasenjit; Goswami, Pooja; Das, Tapash; Nag, Tapas; Sreenivas, Vishnubhatla; Ahuja, Vineet; Panda, Subrat; Gupta, Siddhartha; Makharia, Govind // Virchows Archiv;Mar2012, Vol. 460 Issue 3, p261 

    We intended to see the pattern of TJ protein expression along with ultrastructural changes in colonic biopsies from patients with Crohn's disease (CD), ulcerative colitis (UC), and tuberculosis (cTB). Colonic biopsies from 11 patients with active CD and ten patients each with active UC and...

  • Gastroduodenitis associated with ulcerative colitis. Hori, Kazutoshi; Ikeuchi, Hiroki; Nakano, Hiroki; Uchino, Motoi; Tomita, Toshihiko; Ohda, Yoshio; Hida, Nobuyuki; Matsumoto, Takayuki; Fukuda, Yoshihiro; Miwa, Hiroto // Journal of Gastroenterology;2008, Vol. 43 Issue 3, p193 

    Ulcerative colitis (UC) is regarded as confined to the colorectum; however, there are several case reports showing upper gastrointestinal involvement. The aim of this study was to examine the prevalence and characteristics of gastroduodenitis associated with UC (GDUC). Esophagogastroduodenoscopy...

  • Hepatic microRNA expression is associated with the response to interferon treatment of chronic hepatitis C. Murakami, Yoshiki; Tanaka, Masami; Toyoda, Hidenori; Hayashi, Katsuyuki; Kuroda, Masahiko; Tajima, Atsushi; Shimotohno, Kunitada // BMC Medical Genomics;2010, Vol. 3, p48 

    Background: HCV infection frequently induces chronic liver diseases. The current standard treatment for chronic hepatitis (CH) C combines pegylated interferon (IFN) and ribavirin, and is less than ideal due to undesirable effects. MicroRNAs (miRNAs) are endogenous small non-coding RNAs that...

  • Recent Indications and Methods of Surgery for Inflammatory Bowel Disease. S. Ohki; S. Terashima; K. Sekikawa; S. Takenoshita; M. Gotoh // Current Drug Targets - Inflammation & Allergy;Jun2003, Vol. 2 Issue 2, p113 

    Inflammatory bowel disease, notably ulcerative colitis (UC) or Crohn disease (CD), is basically benign, but sometimes develops into serious or fatal cancer. While the primary therapies are medical, such as pharmacotherapy and dietetic modification, intractable, serious, and cancerous cases can...

  • Ulcerative colitis. Ghosh, Subrata // BMJ: British Medical Journal (International Edition);04/22/2000, Vol. 320 Issue 7242, p1119 

    Provides information on ulcerative colitis. Clinical features and diagnosis; Etiology; Clinical management; Failure of medical management and its indications for surgery.


Read the Article


Sign out of this library

Other Topics