No association between the functional CARD4 insertion! deletion polymorphism and inflammatory bowel diseases in the German population

Franke, A.; Ruether, A.; Wedemeyer, N.; Karisen, T. H.; Nebel, A.; Schreiber, S.
November 2006
Gut;Nov2006, Vol. 55 Issue 11, p1679
Academic Journal
The article explains the disassociation between the functional CARD15 insertion or deletion polymorphism and inflammatory bowel diseases in the German population. According to sources, inflammatory bowel diseases are represented by two main subtypes, Crohn's disease (CD) and ulcerative colitis. Based from observations, identification of functional CARD15 variants revealed the important role of impaired barrier integrity and host defence in the pathogenesis of CD and other inflammatory diseases.


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