Lack of association of the pregnane X receptor (PXR/ NR1I2) gene with inflammatory bowel disease: parallel allelic association study and gene wide haplotype analysis

Ho, G.-T.; Soranzo, N.; Tate, S. K.; Drummond, H.; Nimmo, E. R.; Tenesa, A.; Arnott, I. D.; Satsangi, J.
November 2006
Gut;Nov2006, Vol. 55 Issue 11, p1676
Academic Journal
The article discusses the lack of association of the pregnane X receptor gene with inflammatory bowel disease determined through a parallel allelic association study and gene wide haplotype analysis. According to sources, dysregulation of this gene may influence intestinal barrier defence and susceptibility to inflammatory bowel disease. Thus, a critical re-evaluation of the allelic variants of the gene as determinants of disease susceptibility and phenotype in the Scottish population.


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