TITLE

Is Panton-Valentine Leukocidin the Major Virulence Determinant in Community-Associated Methicillin-Resistant Staphylococcus aureus Disease?

AUTHOR(S)
Voyich, Jovanka M.; Otto, Michael; Mathema, Barun; Braughton, Kevin R.; Whitney, Adeline R.; Welty, Diane; Long, R. Daniel; Dorward, David W.; Gardner, Donald J.; Lina, Gérard; Kreiswirth, Barry N.; DeLeo, Frank R.
PUB. DATE
December 2006
SOURCE
Journal of Infectious Diseases;12/15/2006, Vol. 194 Issue 12, p1761
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Methicillin-resistant Staphylococcus aureus (MRSA) remains a major problem in hospitals, and it is now spreading in the community. A single toxin, Panton-Valentine leukocidin (PVL), has been linked by epidemiological studies to community-associated MRSA (CA-MRSA) disease. However, the role that PVL plays in the pathogenesis of CA-MRSA has not been tested directly. To that end, we used mouse infection models to compare the virulence of PVL-positive with that of PVL-negative CA-MRSA representing the leading diseasecausing strains. Unexpectedly, strains lacking PVL were as virulent in mouse sepsis and abscess models as those containing the leukotoxin. Isogenic PVL-negative (lukS/F-PV knockout) strains of USA300 and USA400 were as lethal as wild-type strains in a sepsis model, and they caused comparable skin disease. Moreover, lysis of human neutrophils and pathogen survival after phagocytosis were similar between wild-type and mutant strains. Although the toxin may be a highly linked epidemiological marker for CA-MRSA strains, we conclude that PVL is not the major virulence determinant of CA-MRSA.
ACCESSION #
23138249

 

Related Articles

  • STIFLE STAPH. Jackson, Dwayne // Joe Weider's Muscle & Fitness;Mar2008, Vol. 69 Issue 3, p264 

    The article offers information on methicillin-resistant Staphylococcus aureus (MRSA). Staphylococcus aureus belongs to a group of bacteria known simply as staph, one of the most frequent causes of skin infections in the U.S. Most of the time, skin infections caused by staph are minor and result...

  • Methicillin-resistant--Staphylococcus aureus Hospitalizations, United States. Kuehnert, Matthew J.; Hill, Holly A.; Kupronis, Benjamin A.; Tokars, Jerome I.; Solomon, Steven L.; Jernigan, Daniel B. // Emerging Infectious Diseases;Jun2005, Vol. 11 Issue 6, p868 

    Melhicillin-resistant Staphylococcus aureus (MRSA) is increasingly a cause of nosocomial and community-onset infection with unknown national scope and magnitude. We used the National Hospital Discharge Survey to calculate the number of US hospital discharges listing S, aureus-specific diagnoses,...

  • Cytolysins, Superantigens, and Pneumonia Due to Community-Associated Methicillin-Resistant Staphylococcus aureus. Schlievert, Patrick M. // Journal of Infectious Diseases;9/1/2009, Vol. 200 Issue 5, p676 

    The author reflects on methicillin-resistant Staphylococccus aureus (MRSA) which cause substantial and fatal infections in the U.S. and is linked to skin and soft-tissue infections, septicemia and pulmonary diseases. He cites a report wherein 4 children have pulmonary infection due to...

  • MRSA: superbug expected to drive growth of niche market.  // PharmaWatch: Monthly Review;Feb2007, Vol. 6 Issue 2, p21 

    The article focuses on the proliferation of the community-acquired methicillin resistant Staphylococcus aureus (MRSA) in Great Britain. The incidence of MRSA is still increasing, making the niche market a highly interesting target for drug developers. Report reveals that the death of a healthy...

  • Rapid screening for MRSA. Wilcox, Mark H. // BMJ: British Medical Journal (International Edition);4/26/2008, Vol. 336 Issue 7650, p899 

    The author reflects on the use of rapid screening for the detection of methicillin resistant staphylococcus aureus (MRSA) infections in hospitals. He suggests that rapid screening is no more effective at reducing the acquisition of MRSA infections than conventional screening methods. He argues...

  • Coexistence of Panton-Valentine Leukocidin—Positive and — Negative Commanity-Associated Methicillin- Resistant Staphylococcus aureus USA400 Sibling Strains in a Large Canadian Health-Care Region. Kunyan Zhang; McClure, Jo-Ann; Elsayed, Sameer; Jonathan Tan; Conly, John M. // Journal of Infectious Diseases;1/15/2008, Vol. 197 Issue 2, p195 

    Community-associated methidilhin-resistant Staphylococcus aureus (CA-MRSA) strains often carry the Panton-Valentine leukocidin (PVL) genes. However, the specific role that PVL plays in the epidemiological features and pathogenesis of CA-MRSA infections has remained undefined and controversial....

  • Community-Associated Meticillin-Resistant Staphylococcus aureus Infections: Epidemiology, Recognition and Management. Mukesh Patel // Drugs;2009, Vol. 69 Issue 6, p693 

    Meticillin-resistant Staphylococcus aureus (MRSA) is an important cause of infection, particularly in hospitalized patients and those with significant healthcare exposure. In recent years, epidemic community-associated MRSA (CA-MRSA) infections occurring in patients without healthcare risk...

  • A Prospective Investigation of Outcomes after Hospital Discharge for Endemic, Community-Acquired Methicillin-Resistant and -Susceptible Staphylococcus aureus Skin Infection. Miller, Loren G.; Quan, Clifford; Shay, Anthony; Mostafaie, Katayoun; Bharadwa, Kiran; Tan, Nelly; Matayoshi, Kelli; Cronin, Jason; Tan, Jennifer; Tagudar, Grace; Bayer, Arnold S. // Clinical Infectious Diseases;2/15/2007, Vol. 44 Issue 4, p483 

    Background. Although community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infection has become increasingly common, prospective data on outcomes of patients with skin infection remain poorly defined. Methods. We prospectively observed a cohort of 201 patients discharged after...

  • Methicillin-Resistant Staphylococcus aureus Infection in the Texas Prison System. Baillargeon, Jacques; Kelley, Michael F.; Leach, Charles T.; Baillargeon, Gwen; Pollock, Brad H. // Clinical Infectious Diseases;5/1/2004, Vol. 38 Issue 9, pe92 

    Recent reports indicate that correctional facility inmates may be at elevated risk for contracting methicillin-resistant Staphylococcus aureus (MRSA) infection because of overcrowding, poor hygiene, and high rates of diseases causing immunosuppression. The present study of 299,179 Texas inmates...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics