TITLE

The effect of infliximab, cyclosporine A and recombinant IL-10 on vitreous cytokine levels in experimental autoimmune uveitis

AUTHOR(S)
Demir, Tamer; Gödekmerdan, Ahmet; Balbaba, Mehmet; Türkçüoglu, Peykan; Ilhan, Fulya; Demir, Nesrin
PUB. DATE
December 2006
SOURCE
Indian Journal of Ophthalmology;Dec2006, Vol. 54 Issue 4, p241
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: To identify the effect of infliximab, cyclosporine A and recombinant IL-10 in experimental autoimmune uveitis. Materials and Methods: Sixty male rats were assigned to five groups of 12 each. All the groups (except the control group) were administered 30 µg retinal-S antigen intraperitoneally. On the 14th day, after confirmation of uveitis with histopathological study, daily cyclosporine A injection was given in cyclosporine A treatment group, and physiological serum in the uveitis-induced placebo treatment and control groups. In the infliximab treatment group, infliximab was administered on the 14th, 15th, 17th, 19th, and 21st days. In the recombinant IL-10 treatment group, three doses of recombinant IL-10 were given four hours and a half hours before and eight hours after retinal-S antigen administration. On the 21st day of the study, all rats were sacrificed and vitreous cytokine levels (IL-1, IL-6, IL-8 and TNF-α) were studied with ELISA. Results: In the treatment groups, cytokine levels (IL-1, IL-6 and TNF-α) were significantly lower than the uveitis-induced placebo treatment group. Compared with the control group, there was no significant difference with respect to TNF-α and IL-8 in the infliximab treatment group; IL-8 in the cyclosporine A treatment group; IL-6 and IL-8 in the recombinant IL-10 treatment group. The drugs used did not significantly differ in respect to their effects on vitreous IL-6, IL-8 and TNF-α levels. Conclusion: Cyclosporine A, infliximab and recombinant IL-10 reduce the vitreous cytokines levels. Among these drugs, recombinant IL-10, which is still in its experimental phase, might be considered as a new therapeutic agent.
ACCESSION #
23130801

 

Related Articles

  • Modulation of Cytokine Expression in Human Myeloid Dendritic Cells by Environmental Endocrine-Disrupting Chemicals Involves Epigenetic Regulation. Chih-Hsing Hung; San-Nan Yang; Po-Lin Kuo; Yu-Te Chu; Hui-Wen Chang; Wan-Ju Wei; Shau-Ku Huang; Yuh-Jyh Jong // Environmental Health Perspectives;Jan2010, Vol. 118 Issue 1, p67 

    Background: Exposure to environmental endocrine-disrupting chemicals (EDCs) is often associated with dysregulated immune homeostasis, but the mechanisms of action remain unclear. Objectives: The aim of this study was to test a hypothesis that EDCs regulate the functions of human dendritic cells,...

  • Immune Cytokine Response in Combat Casualties: Blast or Explosive Trauma with or without Secondary Sepsis. Surbatovic, Maja; Filipovic, Nikola; Radakovic, Sonja; Stankovic, Nebojsa; Slavkovic, Zoran // Military Medicine;Feb2007, Vol. 172 Issue 2, p190 

    The aim of this study was to assess the prognostic value of tumor necrosis factor (TNF) α, interleukin (IL)-8, IL-4, and IL-10 in combat casualties. Fifty-six casualties with severe trauma (blast and explosive) who developed sepsis and 20 casualties with the same severity of trauma without...

  • Lower Serum IL-10 Is an Independent Predictor of IBS Among Volunteers in Mexico. Schmulson, Max; Pulido-London, Daniela; Rodriguez, Oscar; Morales-Rochlin, Norma; Martinez-García, Rosalinda; Gutierrez-Ruiz, Ma Concepción; López-Alvarenga, Juan Carlos; Robles-Díaz, Guillermo; Gutiérrez-Reyes, Gabriela // American Journal of Gastroenterology;May2012, Vol. 107 Issue 5, p747 

    OBJECTIVES:Studies suggest that altered immune activation, manifested by an imbalance in anti- and pro-inflammatory cytokine levels, exists in a subgroup of irritable bowel syndrome (IBS) patients. However, similar studies have not been conducted in Latin populations. The objective of this study...

  • Authors' response. Gils, Ann; Vermeire, Séverine; Van Assche, Gert; Rutgeerts, Paul // Gut;Sep2010, Vol. 59 Issue 9, p1299 

    In this the article, the authors respond to a commentary to their study on tumor necrosis factor (TNF) and antibodies. It cites the argument of the critics on the use of solid-phase assays (ELISAs) compared to soluble-phase radioimmunoassays (RIAs) in measuring antibodies to infliximab (ATI)....

  • Demonstration of specific antibodies against infliximab induced during treatment of a patient with ankylosing spondylitis. Aybay, Canan; Ozel, Sumru; Aybay, Cemalettin // Rheumatology International;Mar2006, Vol. 26 Issue 5, p473 

    Therapeutic proteins, such as infliximab, have revolutionized the treatment of many diseases during the last decade and more than 80 therapeutic proteins are currently approved for clinical use. However, all exogenous proteins have the potential to cause antibody formation. In order to ensure...

  • Channa striatus capsules induces cytokine conversion in pulmonary tuberculosis patients. Paliliewu, Novita; Datau, Eulis A.; Matheos, Julia C.; Surachmanto, Eko E. // Journal of Experimental & Integrative Medicine;2013, Vol. 3 Issue 3, p237 

    Objective: This study aimed to investigate whether Channa striatus capsule induces sputum and cytokine conversion in pulmonary tuberculosis (TB) patients. Methods: Randomized, placebo-controlled, double-blind pilot study was conducted to pulmonary TB patients who admitted to Department of...

  • The effect of acute physical exercise on cytokine levels in patients with systemic lupus erythematosus. da Silva, AE; dos Reis-Neto, E Torres; da Silva, NP; Sato, EI // Lupus;Dec2013, Vol. 22 Issue 14, p1479 

    The article presents a study which evaluates the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-10, and IL-6 in 27 patients with systemic lupus erythematosus (SLE) after acute physical exercise. The study uses the enzyme-linked immunosorbent serologic assay (ELISA) test for the...

  • Regulation of osteoarthritis-associated key mediators by TNFα and IL-10: effects of IL-10 overexpression in human synovial fibroblasts and a synovial cell line. Mrosewski, I.; Jork, N.; Gorte, K.; Conrad, C.; Wiegand, E.; Kohl, B.; Ertel, W.; John, T.; Oberholzer, A.; Kaps, C.; Schulze-Tanzil, G. // Cell & Tissue Research;Jul2014, Vol. 357 Issue 1, p207 

    Synovial fibroblasts (SF) contribute to the pathogenesis of osteoarthritis (OA), but the effects of intra-articular cytokines on SF are not completely understood. The aim of this study was to characterize the interplay between tumor necrosis factor (TNF)α and the anti-inflammatory interleukin...

  • The clinical significance of level changes of hs-CRP, IL-10 and TNF for patients with MS during active and relieving period. JI, A.-L.; LIU, Z-H.; CHEN, W.-W.; HUANG, W.-J. // European Review for Medical & Pharmacological Sciences;2016, Vol. 20 Issue 20, p4274 

    OBJECTIVE: To investigate the clinical significance of the change of the level of hs-CRP, interleukin-10 (IL-10) and tumor necrosis factors (TNF-a) for patients with multiple sclerosis (MS) during the active and the relieving period. PATIENTS AND METHODS: 36 patients with MS during the active...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics