TITLE

Protective Immunity to Cytomegalovirus (CMV) Retinitis in AIDS Is Associated with CMV-Specific T Cells That Express Interferon-γ and Interleukin-2 and Have a CD8+ Cell Early Maturational Phenotype

AUTHOR(S)
Sinclair, Elizabeth; Qi Xuan Tan; Sharp, Margaret; Girling, Valerie; Chungkee Poon; Van Natta, Mark; Jabs, Douglas A.; Inokuma, Margaret; Maecker, Holden T.; Bredt, Barry; Jacobson, Mark A.
PUB. DATE
December 2006
SOURCE
Journal of Infectious Diseases;12/1/2006, Vol. 194 Issue 11, p1537
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
To determine potential correlates of immune recovery from AIDS-related cytomegalovirus retinitis (CMVR), multiparameter flow cytometry was used to characterize CMV-specific T cells from subjects with CMVR. Individuals with active retinitis were compared with those who had been clinically immunorestored by antiretroviral therapy and had ≥2 years of ophthalmologic follow-up without anti-CMV therapy or retinitis reactivation or progression. In comparison with patients with active retinitis, immunorestored patients had higher circulating CD4+ and CD8+ T cells expressing interleukin-2 and interferon-γ in response to combined CMV pp65 and IE1 peptide pool stimulation. CD4+ T cell responses were predominantly to pp65, whereas CD8+ T cell responses were predominantly to IE. Immunorestored patients, compared with patients with active retinitis, had increased levels of circulating CMV-specific CD8+ T cells with ‘early’ (CD27+CD28+CD45RA+, CD27+CD28+CD45RA-) and ‘intermediate’ (CD27-CD28+CD45RA-) phenotypes. Recovery from AIDS-related CMVR after the initiation of antiretroviral therapy may be mediated by CMV-specific CD4+ and CD8+ T cells capable of promoting antigen-specific CD8+ T cell proliferation.
ACCESSION #
23082505

 

Related Articles

  • IL-2 Therapy for AIDS.  // Clinical Infectious Diseases;7/1/2007, Vol. 45 Issue 1, pv 

    The article presents a study conducted by R. Mitsayu and colleagues which investigates the effects of interleukin 2 with potent antiretroviral therapy on patients with moderately advanced human immunodeficiency virus (HIV) infection. A total of 159 patients were available for analysis. Forty and...

  • Polyfunctional T-Cell Responses Are Disrupted by the Ovarian Cancer Ascites Environment and Only Partially Restored by Clinically Relevant Cytokines. Tran, Eric; Nielsen, Julie S.; Wick, Darin A.; Ng, Alvin V.; Johnson, Lisa D. S.; Nesslinger, Nancy J.; McMurtrie, Elissa; Webb, John R.; Nelson, Brad H. // PLoS ONE;2010, Vol. 5 Issue 12, p1 

    Background: Host T-cell responses are associated with favorable outcomes in epithelial ovarian cancer (EOC), but it remains unclear how best to promote these responses in patients. Toward this goal, we evaluated a panel of clinically relevant cytokines for the ability to enhance multiple T-cell...

  • Signature profiles of CMV-specific T-cells in patients with CMV reactivation after hematopoietic SCT. Król, L.; Stuchlý, J.; Hubáček, P.; Keslová, P.; Sedláček, P.; Starý, J.; Hrušák, O.; Kalina, T. // Bone Marrow Transplantation;Aug2011, Vol. 46 Issue 8, p1089 

    Depletion of cellular immunity as a consequence of conditioning before allogeneic hematopoietic SCT (HSCT) frequently results in CMV reactivation, which may in turn lead to life-threatening infections and require timely antiviral treatment. We have investigated the functional signatures of...

  • Natural killer cell proliferation induced by anti-NK1.1 and IL-2. YOKOYAMA; Yokoyama // Immunology & Cell Biology;Apr1998, Vol. 76 Issue 2, p143 

    NKR-P1 molecules are involved in natural killing of certain tumour targets. Indeed, the NK1.1 (NKR-P1C) molecule is the most specific serological marker on murine NK cells in C57BL/6 mice. Previous studies of NKR-P1 have indicated that anti-NKR-P1 mAb induced NK cells to kill otherwise...

  • T-lymphocyte function after retroviral-mediated thymidine kinase gene transfer and G418 selection. Di Ianni, Mauro; Di Florio, Sabrina; Venditti, Gigliola; Liberatore, Concetta; Lucheroni, Francesca; Falzetti, Franca; Terenzi, Adelmo; Carlo Stella, Carmelo; Spinozzi, Fabrizio; Mannoni, Patrice; Martelli, Massimo F; Tabilio, Antonio // Cancer Gene Therapy;Jun2000, Vol. 7 Issue 6, p920 

    Generation of an efficient graft-versus-leukemia (GVL) effect in patients with hematological malignancies who relapse after allogeneic bone marrow transplantation depends in part upon the number of infused T lymphocytes. Currently, a GVL reaction cannot be achieved without inducing concomitant...

  • Infection of CD8+CD45RO+ Memory T-Cells by HIV-1 and Their Proliferative Response. Gulzar, Naveed; Balasubramanian, Sowyma; Harris, Greg; Sanchez-Dardon, Jaime; Copeland, Karen F. T. // Open AIDS Journal;2008, Vol. 2, p43 

    CD8+ T-cells are involved in controlling HIV-1 infection by eliminating infected cells and secreting soluble factors that inhibit viral replication. To investigate the mechanism and significance of infection of CD8+ T-cells by HIV-1 in vitro, we examined the susceptibility of these cells and...

  • cytostatic.  // Taber's Cyclopedic Medical Dictionary (2009);2009, Issue 21, p574 

    A definition of the term "cytostatic" is presented, which refers to a state that prevents cell growth and cell proliferation.

  • Specific and nonspecific NK cell activation during virus infection. Dokun, Ayotunde O.; Kim, Sungjin; Smith, Hamish R.C.; Kang, Hyun-Seok P.; Chu, Dortha T.; Yokoyama, Wayne M. // Nature Immunology;Oct2001, Vol. 2 Issue 10, p951 

    The natural killer (NK) cell activation receptor Ly49H is required for resistance to murine cytomegalovirus (MCMV). We show here that NK cell proliferation and production of interferon-γ (IFN-γ) was not dependent on Ly49H expression during early MCMV infection. During a later phase of...

  • Target-cell-induced anergy in natural killer cells: suppression of cytotoxic function. Das, Suvendu; Varalakshmi, C.; Khar, Ashok // Cancer Immunology, Immunotherapy;Apr2000, Vol. 49 Issue 2, p109 

    Our earlier studies have demonstrated that natural killer (NK) cells are the effectors that participate during the spontaneous regression of AK-5 tumour in syngeneic hosts. We have shown that the tumour cells are killed by necrosis and apoptosis. In this study, we have examined the induction of...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics