TITLE

Safety and Effectiveness of Long-Acting Inhaled β-Agonist Bronchodilators When Taken with Inhaled Corticosteroids

AUTHOR(S)
Ernst, Pierre; McIvor, Andrew; M. Ducharme, Francine; Boulet, Louis-Philippe; FitzGerald, Mark; R. Chapman, Kenneth; Bai, Tony
PUB. DATE
November 2006
SOURCE
Annals of Internal Medicine;11/7/2006, Vol. 145 Issue 9, p692
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Long-acting β-agonists are a pillar of therapy for many patients with asthma because they are the preferred add-on therapy to inhaled corticosteroids. However, a recent meta-analysis documented a substantial increase in severe exacerbations requiring hospital admission and life-threatening asthma exacerbations in patients treated with long-acting β-agonists. A careful evaluation of this meta-analysis raises several concerns about its applicability to current practice. Pivotal trials evaluating the benefit of adding long-acting β-agonists to inhaled corticosteroids were not included. The authors of the current paper call for physicians to continue their usual practice of using long-acting β-agonists as adjunctive therapy, as well as for an independent meta-analysis of individual patients using inhaled corticosteroids and long-acting β-agonists concomitantly.
ACCESSION #
23010625

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics