TITLE

Early Procoagulant Shift in the Bronchoalveolar Compartment of Patients with Secondary Peritonitis

AUTHOR(S)
van Till, J. W. Olivier; Levi, Marcel; Bresser, Paul; Schultz, Marcus J.; Gouma, Dirk J.; Boermeester, Marja A.
PUB. DATE
November 2006
SOURCE
Journal of Infectious Diseases;11/1/2006, Vol. 194 Issue 9, p1331
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background. In acute respiratory distress syndrome or pneumonia, a procoagulant shift is observed in bronchoalveolar lavage fluid (BALF). The effect of a primarily extrapulmonary infection on coagulation and fibrinolysis in the pulmonary compartment is unclear. Methods. In 35 patients, 87 bronchoalveolar lavages were performed on the day of operation for secondary peritonitis (day 0) and on days 2 and 3 after surgery. Two noninfectious control groups were included: subjects undergoing bronchoalveolar lavage after elective surgery (n = 8) and those undergoing long-term mechanical ventilation (n = 10). Results. In BALF from patients with peritonitis, a tissue factor (TF)/factor VIIa—mediated activation of coagulation was shown (high levels of thrombin-antithrombin complexes). Levels of fibrinolysis activators decreased rapidly after day 0, whereas levels of inhibitors increased. The net effect was reduced fibrinolysis (plasminogen activator activity). The sequential comparison of plasma levels of TF pathway inhibitor showed higher levels in patients who died (28-day mortality; P< .001). Sequential levels of TF in BALF were higher in patients with low PaO2:FiO2 ratios (<200; P = .039). Differences between patients and control subjects were more pronounced in BALF than in plasma. Conclusions. Secondary peritonitis induces an early activation of the coagulation and inhibition of fibrinolysis in the systemic and bronchoalveolar compartments, possibly via a compartmentalized response. This imbalance may be associated with reduced oxygen delivery and an adverse outcome in secondary peritonitis.
ACCESSION #
22915106

 

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