Selective reduction of amyloid β42 discriminates Alzheimer's disease from Huntington's disease: indication for distinct pathological events in amyloid β peptide aggregation

Mollenhauer, B.; Bibl, M.; Esselmann, H.; Steinacker, P.; Trenkwalder, C.; Brechlin, P.; Wiltfang, J.; Otto, M.
October 2006
Journal of Neurology, Neurosurgery & Psychiatry;Oct2006, Vol. 77 Issue 10, p1201
Academic Journal
The article discusses the distinction between Huntington's disease and Alzheimer's disease. Both are neurodegenerative disorders associated with the aggregation of misfolded polypeptides that result to amyloids and neuronal damage. Huntington's disease is brought by the expanded glutamine repeats that encode polyglutamine tracts of the gene encoding the huntingtin protein. On the other hand, extracellular amyloid peptides β form amyloid plaques in the brain in Alzheimer's disease.


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