Predictors of occupational exposure to styrene and styrene-7,8-oxide in the reinforced plastics industry

Serdar, B.; Tornero-Velez, R.; Echeverria, D.; Nylander-French, L. A.; Kupper, L. L.; Rappaport, S. M.
October 2006
Occupational & Environmental Medicine;Oct2006, Vol. 63 Issue 10, p707
Academic Journal
Objective: To identify demographic and work related factors that predict blood levels of styrene and styrene-7,8-oxide (SO) in the fibreglass reinforced plastics (FRP) industry. Methods: Personal breathing-zone air samples and whole blood samples were collected repeatedly from 328 reinforced plastics workers in the Unuted States between 1996 and 1999. Styrene and its major metabolite SO were measured in these samples. Multivariable linear regression analyses were applied to the subject-specific levels to explain the variation in exposure and biomarker levels. Results: Exposure levels of styrene were approximately 500-fald higher than those of SO. Exposure levels of styrene and SO varied greatly among the types of products manufactured, with an 11-fald range of median air levels among categories far styrene and a 23-fold range far SO. Even after stratification by job title, median exposures of styrene and SO among laminators varied 14- and 31-fald across product categories. Furthermore, the relative proportions of exposures to styrene and SO varied among product categories. Multivariable regression analyses explained 70% and 63% of the variation in air levels of styrene and SO, respectively, and 72% and 34% of the variation in blood levels of styrene and SO, respectively. Overall, air levels of styrene and SO appear to have decreased substantially in this industry over the last 10–20 years in the US and were greatest among workers with the least seniority. Conclusions: As levels of styrene and SO in air and blood varied among product categories in the FRP industry, use of job title as a surrogate far exposure can introduce unpredictable measurement errors and can confound the relation between exposure and health outcomes in epidemiology studies. Also, inverse relations between the intensity of exposure to styrene and SO and years on the job suggest that younger workers with little seniority are typically exposed to higher levels of styrene and SO than their coworkers.


Related Articles

  • Baseline Na-Li countertransport and risk of hypertension in children: a 10-year prospective study in Hanzhong children. Mu, J.; Liu, Z.; Yang, D.; Liang, Y.; Wang, Z.; Hou, R. // Journal of Human Hypertension;Dec2004, Vol. 18 Issue 12, p885 

    Sodium-lithium countertransport (Na-Li CT) is associated with blood pressure (BP) and in many cross-sectional investigations and some longitudinal studies, essential hypertension has been proposed as a biochemical marker or predictor of hypertension risk in adults. The present study investigated...

  • Wash. wants Spokane to change WTE report. Geiselman, Bruce // Waste News;11/16/98, Vol. 4 Issue 27, p4 

    Discloses the Washington state's decision not to reimburse Spokane for a $300,000 health risk study on the city's waste-to-energy plant unless it corrects shortcomings. Consultant Kathryn Kelly's defense of her study; Major flaws identified by the state's Department of Ecology concerning the...

  • Incidence of dimethylacetamide induced hepatic injury among new employees in a cohort of elastane fibre workers. Lee, C.-Y.; Jung, S.-J.; Kim, S.-A.; Park, K.-S.; Ha, B.-G. // Occupational & Environmental Medicine;Oct2006, Vol. 63 Issue 10, p688 

    Objective: To investigate the incidence of N,N-dimethylacetamide (DMA) induced hepatic injury among new elastane fibre workers and to explore factors relating to DMA induced hepatic injury. Methods: Elastane fibre workers exposed to DMA were monitored far hepatic injury. Four hundred and forty...

  • Effect of styrene oxide on dopamine receptors in rats Agrawal, A. K.; Srivastava, S. P.; Seth, P. K.; Zaidi, N. F. // Bulletin of Environmental Contamination & Toxicology;Nov1985, Vol. 35 Issue 5, p602 

    No abstract available.

  • Effect of styrene oxide on levels of biogenic amines and activity ofmonoamine oxidase in different parts of rat brain Seth, P. K.; Husain, R.; Srivastava, S. P.; Zaidi, N. F. // Bulletin of Environmental Contamination & Toxicology;May1985, Vol. 34 Issue 5, p722 

    No abstract available.

  • High-flow nasal cannula as a device to provide continuous positive airway pressure in infants. Spence, K. L.; Murphy, D.; Kilian, C.; McGonigle, R.; Kilani, R. A. // Journal of Perinatology;Dec2007, Vol. 27 Issue 12, p772 

    Objective:To measure the intrapharyngeal pressure (IPP) generated by high-flow nasal cannula (HFNC) at varying flow rates up to 5 l min−1.Study Design:We studied 14 infants on HFNC or NCPAP using IPP manometry to measure the IPP generated at flows of 1, 2, 3, 4 and 5 l...

  • International collaborative research: a Colombian model that promotes infant health and research capacity. Rojas, M. A.; Lozano, J. M.; Rojas, M. X. // Journal of Perinatology;Dec2007, Vol. 27 Issue 12, p738 

    Current collaborative efforts in international research with resource-poor nations are frequently paternalistic and deprive these nations of the skills necessary to build independent research capacity. Resource-poor nations have become progressively suspicious of research endeavors originated in...

  • Asbestos advice for councils.  // RoSPA Occupational Safety & Health Journal;Dec2007, Vol. 37 Issue 12, p10 

    The article reports on a recommendation from the Health Protection Agency (HPA) in Great Britain that local authorities develop policies for dealing with fires involving asbestos materials. The HPA reports says proper cleanup operations can minimize public health risks such as mesothelioma and...

  • EPIDEMIOLOGY OF SUICIDES IN RIO GRANDE DO SUL. Meneghel, S.; Victora, C.; Faria, N.; Carvalho, L.; Falk, J. // Journal of Epidemiology & Community Health;Aug2004 Supplement 1, Vol. 58, pA40 

    The article profiles the issue of suicide in the state of Rio Grande do Sul. Rio Grande do Sul evidenced the highest rates for suicide in Brazil during the period under study. The standardized coefficients went from levels around 9/100000 in the 1980s to 11/100000 in 1999. The study points to...


Read the Article


Sign out of this library

Other Topics