Axillary Regional Recurrence After Sentinel Lymph Node Biopsy for Breast Cancer

Rosing, David K.; Dauphine, Christine E.; Vargas, M. Perla; Gonzalez, Katherine; Burla, Melissa; Kaufmann, Paul; Vargas, Hernan I.
October 2006
American Surgeon;Oct2006, Vol. 72 Issue 10, p939
Academic Journal
The accuracy of sentinel lymph node biopsy (SLNB) staging in breast cancer has been demonstrated in studies comparing it with axillary dissection. There is a 5 per cent false-negative rate, but this does not always correlate with axillary recurrence. Our purpose was to determine the rate of axillary lymphatic recurrence in breast cancer patients who had a negative SLNB. We conducted a cohort study of breast cancer patients who underwent SLNB between 2001 and 2005. Only patients who had a negative SLNB were included. Patient demographics and tumor factors were reviewed. Outcomes measured were axillary and systemic recurrence and survival. Eighty-nine patients with a mean age of 54.4 ± 9.9 years were included. Eighty-nine per cent of cases had infiltrating ductal carcinoma histology. Mean tumor size was 19 ± 14 mm. Breast conservation surgery was done in 65 cases and mastectomy in 24. A mean of 2.3 ± 2.4 SLN were found. After a median follow-up of 2.15 years, 1 (1%) patient developed a lymphatic recurrence in the axilla. SLNB provides accurate staging of breast cancer. Patients with negative SLNB do not require axillary dissection.


Related Articles

  • The Effect of Excisional Biopsy on the Accuracy of Sentinel Lymph Node Mapping in Early Stage Breast Cancer: Comparison with Core Needle Biopsy. FORGHANI, MOHAMMAD NASER; MEMAR, BAHRAM; JANGJOO, ALI; ZAKAVI, RASOUL; MEHRABIBAHAR, MOSTAFA; DABBAGH KAKHKI, VAHID REZA; KASHANI, IDA; HASHEMIAN, FARNAZ; SADEGHI, RAMIN // American Surgeon;Nov2010, Vol. 76 Issue 11, p1232 

    Despite the successful application of sentinel node mapping in breast cancer patients, its use in patients with a history of previous excisional biopsy of the breast tumors is a matter of controversy. In the present study we evaluated the accuracy of sentinel node biopsy in this group of...

  • Clinical relevance of sentinel lymph nodes in the internal mammary chain in breast cancer patients. Paredes, Pilar; Vidal-Sicart, Sergi; Zanón, Gabriel; Pahisa, Jaume; Fernández, Pedro Luís; Velasco, Martín; Santamaría, Gorane; Ortín, Jaime; Duch, Joan; Pons, Francesca // European Journal of Nuclear Medicine & Molecular Imaging;Nov2005, Vol. 32 Issue 11, p1283 

    Purpose: Despite the widespread use of sentinel lymph node (SLN) biopsy in breast cancer patients, some controversy exists about the correct management of extra-axillary nodes, especially those located in the internal mammary chain. The aim of this study was to evaluate the incidence of SLNs in...

  • Intraoperative Consultation for Axillary Sentinel Lymph Node Biopsy: An 8-Year Audit. Nofech-Mozes, Sharon; Hanna, Wedad M.; Cil, Tulin; Quan, May-Lynn; Holloway, Claire; Khalifa, Mahmoud A. // International Journal of Surgical Pathology;Apr2010, Vol. 18 Issue 2, p129 

    To summarize the authors' 8-year institutional experience with intraoperative consultation via frozen section (FS) on sentinel lymph node biopsy (SLNB) in breast cancer patients we recorded the, complete operative procedure including additional surgery on the ipsilateral axilla and...

  • Sparing sentinel node biopsy through axillary lymph node fine needle aspiration in primary breast cancers. Yu-Shu Cheng; Shou-Jen Kuo; Dar-Ren Chen // World Journal of Surgical Oncology;2013, Vol. 11 Issue 1, p1 

    Background Axillary lymph node status is an important staging and prognostic factor in breast cancer. This study aimed to evaluate the efficacy of axilla fine needle aspiration cytology (FNAC) in primary breast cancer without a palpable node and even without image characteristics of a metastatic...

  • Sentinel lymph node biopsy in early-stage breast cancer patients: improved survival through better staging? Meiers, Pamela; Cil, Tulin; Guller, Ulrich; Zuber, Markus // Langenbeck's Archives of Surgery;Jun2013, Vol. 398 Issue 5, p687 

    Purpose: The objective of this review is to summarize the evidence demonstrating that the sentinel lymph node (SLN) procedure is not only associated with significantly less morbidity compared to the axillary dissection, but may also result in better staging and improved patient outcomes....

  • The value of intraoperative frozen section examination of sentinel lymph nodes in surgical management of breast carcinoma. Cipolla, Calogero; Cabibi, Daniela; Fricano, Salvatore; Vieni, Salvatore; Gentile, Irene; Latteri, Mario Adelfio // Langenbeck's Archives of Surgery;Aug2010, Vol. 395 Issue 6, p685 

    In breast cancer staging, the need for intraoperative sentinel lymph node (SLN) evaluation has still not been adequately established. This study investigates the impact of intraoperative frozen section (FS) evaluation of SLN to avoid subsequent axillary lymph node dissection (ALND) in patients...

  • Current status of sentinel lymph-node biopsy in patients with breast cancer. Cheng, Gang; Kurita, Stephanie; Torigian, Drew; Alavi, Abass // European Journal of Nuclear Medicine & Molecular Imaging;Mar2011, Vol. 38 Issue 3, p562 

    xillary node status is the most important prognostic indicator for patients with invasive breast cancer. Sentinel lymph-node biopsy (SLNB) is widely accepted and the preferred procedure for identifying lymph-node metastasis. SLNB allows focused excision and pathological examination of the most...

  • Lokal Ä°leri Evre Meme Kanserlerinde Meme Koruyucu Cerrahi ve Sentinel Lenf Nodu Örneklemesi: Tek Merkez Deneyimi. Sezer, Atakan; Alas, Ruşen Coşar; Cicin, İrfan; Hoşcoşkun, Zeki; Tunçbilek, Nermin // Balkan Medical Journal;Jun2011, Vol. 28 Issue 2, p138 

    Objective: Patients with locally advanced breast cancer may undergo breast conserving surgery after neoadjuvant chemotherapy. The aim of the study is to evaluate the results of locally advanced breast cancer patients who underwent breast conserving surgery, axi l l a ry dissection and sentinel...

  • Accuracy of Sentinel Lymph Node Biopsy for Patients with T[sub2] and T[sub3] Breast Cancers. Wong, Sandra L.; Chad, Celia; Edwards, Michael J.; Simpson, Diana; McMasters, Kelly M.; Tuttle, Todd M.; Noyes, R. Dirk; Carlson, David J.; Laidley, Alison L.; McGlothin, Terre Q.; Ley, Philip B.; Brown, C. Matthew; Glaser, Rebecca L.; Pennington, Robert E.; Turk, Peter S. // American Surgeon;Jun2001, Vol. 67 Issue 6, p522 

    Although numerous studies have demonstrated that sentinel lymph node (SLN) biopsy can accurately determine the axillary nodal status for early breast cancer some studies have suggested that SLN biopsy may be less reliable for tumors >2 cm in size. This analysis was performed to determine whether...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics