Comparison of Laser Epithelial Keratomileusis With and Without the Use of Mitomycin C

Argento, Carlos; Cosentino, María José; Ganly, Marcela
October 2006
Journal of Refractive Surgery;Oct2006, Vol. 22 Issue 8, p782
Academic Journal
PURPOSE: To analyze the results of prophylactic intra-operative use of mitomycin C (MMC) in laser epithelial keratomileusis (LASEK). METHODS: A retrospective analysis of 30 LASEK cases that received MMC 0.02% intraoperatively (MMC group) was performed and compared to the results obtained in 28 LASEK cases not receiving MMC (no MMC group). Mitomycin C was placed in contact with the ablation zone for 75 seconds with an imbibed microsponge. Both groups received postoperative fluorometholone for 3 months. Preoperative spherical equivalent refraction was -5.72±2.82 diopters (D) in the MMC group and -5.81±2.74 D in the no MMC group. Best spectacle-corrected visual acuity was 0.88±0.12 in the MMC group and 0.88±0.13 in the no MMC group. RESULTS: Spherical equivalent refraction at 6 months postoperatively was +0.11±0.13 D in the MMC group and +0.09±0.37 D in the no MMC group. Best spectacle-corrected visual acuity was 0.90±0.13 in the MMC group and 0.88±0.13 in the no MMC group. Uncorrected visual acuity (UCVA) ≥20/40 was obtained in 93.3% of cases in the MMC group and in 89.3% of cases in the no MMC group; UCVA ≥20/25 was achieved in 76.6% of cases in the MMC group and in 71.4% of cases in the no MMC group. Haze incidence for the MMC group was: trace: 0%, Grades I: 0%, II: 0%, III: 0%, IV: 0%, and for the no MMC group: trace: 17.9%, Grades I: 3.6%, II: 0%, III: 0%, IV: 0%. A statistically significant difference (P<.001) was noted in haze intensity between the MMC group and no MMC group. CONCLUSIONS: Prophylactic use of intraoperative MMC in LASEK significantly decreases haze incidence.


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